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| 1 | 利用接收函数研究六盘山地区地壳上地幔结构特征显示文摘利用六盘山地区宽频带流动地震台阵的远震体波记录,采用接收函数方法研究台阵下方的地壳上地幔结构,并采用接收函数振幅加权叠加方法对这一地区平均地壳厚度和泊松比进行估算.研究结果显示,青藏高原东北缘和鄂尔多斯的接触过渡带接收函数震相复杂,地壳变形强烈,青藏高原东北缘地壳平均厚度约为51.5km,六盘山下方地壳厚度在53.5km,鄂尔多斯西南缘地壳平均厚度约为50km,整个莫霍面呈下凹状.泊松比计算结果显示,六盘山东侧和西侧地壳泊松比值在正常范围内(0.25~0.26),六盘山下方的地壳泊松比值偏高(0.27~0.29),推测与地壳中存在部分熔融.泊松比值的横向变化,指示测线范围地壳物质组成和力学性质存在横向差异,反映在欧亚板块与印度板块碰撞作用影响下青藏高原下地壳物质存在向北东方向的流动. | 童蔚蔚 王良书 米宁 徐鸣洁 李华 于大勇 李成 刘绍文 Mian Liu Eric Sandvol | 2007 | 中国科学(D辑)2007，37，A01： | 19 |
| 2 | 大陆内部长余震序列及其对地震风险评估的启示显示文摘板块构造学说的最有力的特征之一,是已知的板块运动让我们对板块边界未来大地震的发震位置和平均复发间隔有更清晰的认识。然而,板块构造学说却不能预测板块内的地震何时何地发生,因为理想的板块内部是不会变形的。因此,板块内部的地震风险评估过于依靠如下假设:从有限的历史记录中得到的小地震发震位置能够反映出连续变形的地区,而变形将诱发未来大地震[1]。然而,本文将要说明的是,最近许多这样的小地震很可能是几百年前发生过的大地震的余震。文中将给出一个简单的模型,并由此模型得出:余震序列的长度和断层加载速率呈反比关系。发生在缓慢变形的大陆内部的余震序列,其持续时间与在快速加载的板块边界所观测到的典型的10年尺度余震序列相比要长得多。因为这些预测与观测结果相符,所以将大陆内部地震看作稳态地震活动的一般做法高估了目前地震活跃地区的地震危险性,而低估了其他地区的地震风险。 | Seth Stein Mian Liu 刘杨(译) 朱守彪(校) | 2009 | 国际地震动态2009，，12： | 19 |
| 3 | Hydraulic fracture initiation theory for a horizontal well in a coal seam显示文摘A series of experiments were performed to determine rock mechanical parameters related to hydraulic fracturing of coal.The effect of confining pressure and pore pressure on the strength of coal was studied.Experimental results show that the coal seam in the study areas has a relatively low elastic modulus,high Poisson's ratio,high fragility and is easily broken and compressed.The coal seam is considered as a transversely isotropic medium,since the physical properties in the direction of bedding plane and orthogonal to the bedding plane vary markedly.Based on the generalized plane strain model,stress distribution for an arbitrarily orientated wellbore in the coal seam was determined.In a horizontal well,hydraulic fracturing was found to initiate in the coal seam mass due to tensile failure,or from cleats due to shear or tensile failure.For those coal seams with abundant natural cleats,hydraulic fracture initiation can be induced by any of these mechanisms.In this study,hydraulic fracture initiation criteria for a horizontal well in a coal seam were established. | Hou Bing Chen Mian Wang Zheng Yuan Jianbo Liu Ming | 2013 | Petroleum Science2013，10，2： | 18 |
| 4 | Three New Anthraquinones from Polygonum cillinerve显示文摘Three new anthraquinones, emodin-8-β-D-(2″-O-coumarate)glucoside 1, emodin-8-β- D-(6′-O-acetyl)glucoside 2 and physicon-8-β-D-(6′-O-acetyl)glucoside 3, were isolated from the roots of Polygonum cillinerve and their structures were established by spectroscopic methods. The biological activity indicated that compound 1 had the scavenging activity on 1,1-diphenyl-2- picrylhydrazyl (DPPH) radicals (the IC50 = 8.5 μmol/L), and compound 1-3 showed no activities against HL-60 and BGC-823 cells by MTT method in vitro. | Huan Yang QI Chao Feng ZHANG Mian ZHANG Jian Qun LIU Zheng Tao WANG | 2005 | Chinese Chemical Letters2005，16，8： | 10 |
| 5 | Receiver function analysis for seismic structure of the crust and uppermost mantle in the Liupanshan area, China显示文摘A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block, China. The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using receiver function analysis of teleseismic body waves. The crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver functions. Our results reveal complex seismic phases in the Liupanshan area, implying intense deformation at the boundary between the Tibetan Plateau and the Ordos block. The average crustal thickness is 51.5 km in the northeast Tibetan Plateau, 53.5 km in the Liupan Mountain and 50 km in the southwest Ordos block, resulting in a concave Moho beneath the Liupan Mountain. The Poisson's ratio of the Liupanshan area varies between 0.27-0.29, higher than the value of 0.25-0.26 to the east and west of the Liupan Mountain, suggesting partial melting in the lower crust. The variance in Poisson's ratio across the Liupan Mountain indicates notable changes in the crustal composition and mechanical properties, which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision. | TONG WeiWei WANG LiangShu MI Ning XU MingJie LI Hua YU DaYong LI Cheng LIU ShaoWen LIU Mian Eric SanDvol | 2007 | Science China Earth Sciences2007，50，z2： | 9 |
| 6 | Randomized Controlled Study on Safety and Feasibility of Transfusion Trigger Score of Emergency Operations显示文摘 | De-Xing Liu Jin Liu Fan Zhang Qiu-Ying Zhang Mian Xie Zhao-Qiong Zhu | 2015 | Chinese Medical Journal2015，，13： | 9 |
| 7 | 天山地震带境内外主要断层滑动速率和地震矩亏损分布特征研究显示文摘本文搜集、整理1998—2013年境内外天山及周边地区(包括中国新疆、哈萨克斯坦、吉尔吉斯斯坦等)500余个GPS观测点数据,采用GAMIT/GLOBK软件对其进行解算和平差计算,并利用了弹性块体模型计算区域块体边界断层闭锁深度、块体运动参数和主要活动断层的滑动速率.研究结果表明,东、西昆仑地震带闭锁深度最大(19km),其次为南天山地区,闭锁深度达到17km,闭锁深度最小的为哈萨克斯坦(13km);各块体相对欧亚板块作顺(逆)时针旋转,旋转速率最大(-0.7208±0.0034°/Ma)为塔里木块体,其围绕欧拉极(38.295±0.019°N,95.078±0.077°E)顺时针方向转动,旋转速率最小为天山东段(0.108±0.1210°/Ma),而天山东、西两段无论是在旋转速率上还是在旋转方向上都有显著的区别.西昆仑断裂带的滑动速率(10.2±2.8mm·a-1)最大,南天山西段滑动速率为9.5±1.8mm·a-1,其东段为3.9±1.1mm·a-1;而北天山东段滑动速率(4.7±1.1mm·a-1)高于北天山西段(3.7±0.9mm·a-1);塔里木盆地南缘的阿尔金断裂带平均滑动速率为7.6±1.4mm·a-1,其结果与阿勒泰断裂带滑动速率(7.6±1.6mm·a-1)基本相当;天山断裂带运动方式主要以挤压为主,而阿尔金、昆仑、阿尔泰以及哈萨克斯坦断裂带均是以走滑运动方式为主,除阿勒泰断裂带走滑方式为右旋以外,其余几个断裂带均为左旋运动.最后,利用主要断裂带的滑动速率计算出各地震带的地震矩变化率以及1900年以来地震矩累计变化量,其结果与利用地震目录计算所得到的地震矩进行比较,判定出各地震带上地震矩均衡分布状态,研究结果显示阿尔金、西昆仑、东昆仑和北天山东段断裂带存在较大的地震矩亏损,均具有发生7级以上地震的可能性,南天山东段和哈萨克斯坦断裂带地震矩亏损相对较小,具有孕育6~7级地震的潜能,而天山西段、阿勒泰地震矩呈现出盈余状态,不具在1~3年内有发生强震的可能. | 刘代芹 LIU Mian 王海涛 李杰 程佳 王晓强 | 2016 | 地球物理学报2016，59，5： | 9 |
| 8 | One-step synthesis of N-doped metal/biochar composite using NH_3-ambiance pyrolysis for efficient degradation and mineralization of Methylene Blue显示文摘A series of new biochar-supported composite based on the combination of biochar and metallic nanoparticles(NPs)were produced through single-step pyrolysis of FeCl_3–Ti(OBu)_4 laden agar biomass under NH_3 environment.The physiochemical properties of composites were characterized thoroughly.It has found that heating temperature and N-doping through NH_3-ambiance pyrolysis significantly influence the visible-light sensitivity and bandgap energy of composites.The catalytic activities of composites were measured by degradation of Methylene Blue(MB)in the presence or absence of H_2O_2 and visible-light irradiation.Our best catalyst(N–TiO_2–Fe_3O_4-biochar)exhibits rapid and high MB removal competency(99.99%)via synergism of adsorption,photodegradation,and Fenton-like reaction.Continuous production of O_2U^-and UOH radicles performs MB degradation and mineralization,confirmed by scavenging experiments and degradation product analysis.The local trap state Ti^(3+),Fe_3O_4,and N-carbon of the catalyst acted as active sites.It has suggested that the Ti^(3+)and N-doped dense carbon layer improve charge separation and shuttle that prolonged photo-Fenton like reaction.Moreover,the catalyst is highly stable,collectible,and recyclable up to 5 cycles with high MB degradation efficiency.This work provides a new insight into the synthesis of highly visible-light sensitized biocharsupported photocatalyst through NH_3-ambiance pyrolysis of NPs-laden biomass. | Md Manik Mian Guijian Liu Balal Yousaf Biao Fu Rafay Ahmed Qumber Abbas Mehr Ahmed Mujtaba Munir Liu Ruijia | 2019 | Journal of Environmental Sciences2019，31，4： | 8 |
| 9 | Design of Robotic Visual Servo Control Based on Neural Network and Genetic Algorithm显示文摘A new visual servo control scheme for a robotic manipulator is presented in this paper, where a back propagation (BP) neural network is used to make a direct transition from image feature to joint angles without requiring robot kinematics and camera calibration. To speed up the convergence and avoid local minimum of the neural network, this paper uses a genetic algorithm to find the optimal initial weights and thresholds and then uses the BP algorithm to train the neural network according to the data given. The proposed method can effectively combine the good global searching ability of genetic algorithms with the accurate local searching feature of BP neural network. The Simulink model for PUMA560 robot visual servo system based on the improved BP neural network is built with the Robotics Toolbox of Matlab. The simulation results indicate that the proposed method can accelerate convergence of the image errors and provide a simple and effective way of robot control. | Hong-Bin Wang Mian Liu | 2012 | International Journal of Automation and computing2012，9，1： | 8 |
| 10 | Effect of the Shensong Yangxin Capsule on Energy Metabolism in Angiotensin II-lnduced Cardiac Hypertrophy显示文摘 | Bei-Lei Liu Mian Cheng Shan Hu Shun Wang Le Wang Zheng-Qing Hu Cong-Xin Huang Hong Jiang Gang Wu | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 11 | Epigenetic regulation of dental pulp stem cells and its potential in regenerative endodontics显示文摘Regenerative endodontics(RE)therapy means physiologically replacing damaged pulp tissue and regaining functional dentin–pulp complex.Current clinical RE procedures recruit endogenous stem cells from the apical papilla,periodontal tissue,bone marrow and peripheral blood,with or without application of scaffolds and growth factors in the root canal space,resulting in cementum-like and bone-like tissue formation.Without the involvement of dental pulp stem cells(DPSCs),it is unlikely that functional pulp regeneration can be achieved,even though acceptable repair can be acquired.DPSCs,due to their specific odontogenic potential,high proliferation,neurovascular property,and easy accessibility,are considered as the most eligible cell source for dentin–pulp regeneration.The regenerative potential of DPSCs has been demonstrated by recent clinical progress.DPSC transplantation following pulpectomy has successfully reconstructed neurovascularized pulp that simulates the physiological structure of natural pulp.The self-renewal,proliferation,and odontogenic differentiation of DPSCs are under the control of a cascade of transcription factors.Over recent decades,epigenetic modulations implicating histone modifications,DNA methylation,and noncoding(nc)RNAs have manifested as a new layer of gene regulation.These modulations exhibit a profound effect on the cellular activities of DPSCs.In this review,we offer an overview about epigenetic regulation of the fate of DPSCs;in particular,on the proliferation,odontogenic differentiation,angiogenesis,and neurogenesis.We emphasize recent discoveries of epigenetic molecules that can alter DPSC status and promote pulp regeneration through manipulation over epigenetic profiles. | Ying Liu Lu Gan Di-Xin Cui Si-Han Yu Yue Pan Li-Wei Zheng Mian Wan | 2021 | World Journal of Stem Cells2021，13，11： | 7 |
| 12 | World’s first spaceflight on-orbit demonstration of a flexible solar array system based on shape memory polymer composites显示文摘With a 10%reversible compressive strain in more than 10 deformation cycles,the shape memory polymer composites(SMPCs)could be used for deployable structure and releasing mechanism.In this paper,without traditional electro-explosive devices or motors/controllers,the deployable SMPC flexible solar array system(SMPC-FSAS)is studied,developed,ground-based tested,and finally on-orbit validated.The epoxy-based SMPC is used for the rolling-out variable-stiffness beams as a structural frame as well as an actuator for the flexible blanket solar array.The releasing mechanism is primarily made of the cyanate-based SMPC,which has a high locking stiffness to withstand 50 g gravitational acceleration and a large unlocking displacement of 10 mm.The systematical mechanical and thermal qualification tests of the SMPC-FSAS flight hardware were performed,including sinusoidal sweeping vibration,shocking,acceleration,thermal equilibrium,thermal vacuum cycling,and thermal cycling test.The locking function of the SMPC releasing mechanisms was in normal when launching aboard the SJ20 Geostationary Satellite on 27 Dec.,2019.The SMPC-FSAS flight hardware successfully unlocked and deployed on 5 Jan.,2020 on geostationary orbit.The triggering signal of limit switches returned to ground at the 139 s upon heating,which indicated the successful unlocking function of SMPC releasing mechanisms.A pair of epoxy-based SMPC rolled variable-stiffness tubes,which clapped the flexible blanket solar array,slowly deployed and finally approached an approximate 100%shape recovery ratio within 60 s upon heating.The study and on-orbit successful validation of the SMPC-FSAS flight hardware could accelerate the related study and associated productions to be used for the next-generation releasing mechanisms as well as space deployable structures,such as new releasing mechanisms with low-shocking,testability and reusability,and ultra-large space deployable solar arrays. | LAN Xin LIU LiWu ZHANG FengHua LIU ZhengXian WANG LinLin LI QiFeng PENG Fan HAO SiDa DAI WenXu WAN Xue TANG Yong WANG Mian HAO YanYan YANG Yang YANG Cheng LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，8： | 7 |
| 13 | Neotuberostemonine inhibits the differentiation of lung fibroblasts into myofibroblasts in mice by regulating HIF-1α signaling显示文摘肺的纤维变性可以部分是响应长期的组织缺氧的 deregulated 织物修理的结果。在这研究,我们在肺成纤维细胞和 neotuberostemonine (NTS ) 的效果上探索了组织缺氧的效果,从 Stemona tuberosa 孤立的自然的碱,在在 vitro 并且在 vivo 的成纤维细胞的激活上。 PLF (主要老鼠肺成纤维细胞)与 CoCl 2( 100 mol/L )在暴露以后被激活并且区分到1% O 2或处理,由显著地增加的蛋白质或 HIF-1 ,TGF-, FGF2 , -SMA 和 Col-1/3 的 mRNA 表示证实了,它在 silencing HIF-1 以后被堵住,建议成纤维细胞的激活是 HIF-1-dependent 。而 NTS 的禁止的效果被合作处理与 MG132 废除, NTS (0.1-10 mol/L ) dose-dependently 压制了 PLF 的导致组织缺氧的激活和区别,一个 proteasome 禁止者。因为 prolyl hydroxylation 是在 HIF-1 降级的开始的关键步,我们进一步在 prolyl hydroxylated-HIF-1 的表示显示出导致组织缺氧的颠倒的那个 NTS 处理或 CoCl 2-induced 减小。与染色的 hypoxyprobe immunofiuorescence,我们证明 NTS 处理直接在暴露组织缺氧的 PLF 颠倒了更低的氧紧张。在肺纤维变性的一个老鼠模型, NTS 的口头的管理(30 mg ? 潭楤汯摩獥 ??? ‵貒?? | Xin-miao LV Ming-dan LI Si CHENG Bao-lin LIU Kang LIU Chao-feng ZHANG Xiang-hong XU Mian ZHANG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 7 |
| 14 | Adsorptive hemofiltration for sepsis management: expert recommendations based on the Asia Pacific experience显示文摘To the Editor:In sepsis,bacterial endotoxins play a central role by inducing a dysregulated and exaggerated release of inflammatory mediators and cytokines,often described as the“cytokine storm”or“cytokinemia.”[1]Both endotoxins and cytokines have been implicated in the development of organ dysfunction,including acute kidney injury(AKI).[2]Removing circulating endotoxins and excess cytokines from the circulation restores chemotactic gradients,localizing the immune response to the principal site of infection and re-establishing a regulated immune response.[1,3]Therefore,using hemofilters with enhanced endotoxin and cytokine adsorptive properties may bring about additional therapeutic benefits compared with conventional continuous renal replacement therapy(CRRT)filters. | Ling Zhang Matthew Cove Binh G.Nguyen Nuttha Lumlertgul Kartik Ganesh Alfred Chan Giang T.H.Bui Chunwen Guo Junhua Li Songqiao Liu Mian Peng Kit W.Foong Jian Zhang Minmin Wang Jacques Goldstein Kai Harenski | 2021 | Chinese Medical Journal2021，，18： | 6 |
| 15 | De novo assembly and comparative analysis of root transcriptomes from different varieties of Panax ginseng C. A. Meyer grown in different environments显示文摘Panax ginseng C. A. Meyer is an important traditional herb in eastern Asia. It contains ginsenosides, which are primary bioactive compounds with medicinal properties. Although ginseng has been cultivated since at least the Ming dynasty to increase production, cultivated ginseng has lower quantities of ginsenosides and lower disease resistance than ginseng grown under natural conditions. We extracted root RNA from six varieties of fifth-year P. ginseng cultivars representing four different growth conditions, and performed Illumina paired-end sequencing. In total, 163,165,706 raw reads were obtained and used to generate a de novo transcriptome that consisted of 151,763 contigs(76,336 unigenes), of which 100,648 contigs(66.3%) were successfully annotated. Differential expression analysis revealed that most differentially expressed genes(DEGs) were upregulated(246 out of 258, 95.3%) in ginseng grown under natural conditions compared with that grown under artificial conditions. These DEGs were enriched in gene ontology(GO) terms including response to stimuli and localization. In particular, some key ginsenoside biosynthesis-related genes, including HMG-Co A synthase(HMGS), mevalonate kinase(MVK), and squalene epoxidase(SE), were upregulated in wild-grown ginseng. Moreover, a high proportion of disease resistance-related genes were upregulated in wild-grown ginseng. This study is the first transcriptome analysis to compare wild-grown and cultivated ginseng, and identifies genes that may produce higher ginsenoside content and better disease resistance in the wild; these genes may have the potential to improve cultivated ginseng grown in artificial environments. | ZHEN Gang ZHANG Lei DU YaNan YU RenBo LIU XinMin CAO FangRui CHANG Qi DENG Xing Wang XIA Mian HE Hang | 2015 | Science China(Life Sciences)2015，58，11： | 6 |
| 16 | Association of insulin-like growth factor-binding protein-3 with radiotherapy response and prognosis of esophageal squamous cell carcinoma显示文摘Background: Insulin?like growth factor?binding protein?3(IGFBP?3) is suggested to predict the radiosensitivity and/or prognosis of patients with esophageal squamous cell carcinoma(ESCC). The present study was designed to investi?gate the clinical and prognostic efects of IGFBP?3 on ESCC.Methods: IGFBP?3 was detected by immunohistochemistry in parain?embedded tissues from 70 ESCC patients treated with radiotherapy alone and further examined by western blotting analysis in 10 pairs of fresh ESCC tissues and adjacent non?malignant esophageal specimens. Receiver operating characteristic(ROC) analysis was used to determine cut?of scores for tumor positivity and to evaluate patient survival status. The χ2 test was performed to analyze the association of IGFBP?3 expression with clinical characteristics and radiotherapy response. Associations between prognostic outcomes and IGFBP?3 expression were investigated using Kaplan–Meier analysis and the Cox proportional hazards model.Results: The threshold for IGFBP?3 positivity was set to greater than 65% [area under the ROC curve(AUC)(45.7%) were deined as having high IGFBP?3 expression= 0.690, P < 0.019]. Of the 70 ESCC patient tissues tested, 32. The levels of IGFBP?3 protein expression were decreased in 70.0%(7 of 10) of ESCC tissues compared with adjacent non?malignant esophageal tissue. In addition, IGFBP?3 expression was associated with pathologic classiication(P < 0.05 for T, N, and M categories and clinical stage). Patients with elevated protein level of IGFBP?3 in the tumor had an improved radiotherapy response and prolonged overall survival(P < 0.001).Conclusions: High level of IGFBP?3 expression in ESCC associates with early clinical stages and are predictive for favorable survival of the patients treated with radiotherapy. | Li-Ling Luo Lei Zhao Mian Xi Li-Ru He Jing-Xian Shen Qiao-Qiao Li Shi-Liang Liu Peng Zhang Dan Xie Meng-Zhong Liu | 2015 | Chinese Journal of Cancer2015，34，11： | 6 |
| 17 | Influence of fault geometry and fault interaction on strain partitioning within western Sichuan and its adjacent region显示文摘There are several major active fault zones in the western Sichuan and its vicinity. Slip rates and seismicity vary on different fault zones. For example, slip rates on the Xianshuihe fault zone are higher than 10 mm/a. Its seismicity is also intense. Slip rates on the Longmenshan fault zone are low. However, Wenchuan Ms8.0 earthquake occurred on this fault zone in 2008. Here we study the impact of fault geometry on strain partitioning in the western Sichuan region using a three-dimensional viscoe- lastoplastic model. We conclude that the slip partitioning on the Xianshuihe-Xiaojiang fault presents as segmented, and it is related to fault geometry and fault structure. Slip rate is high on fault segment with simple geometry and structure, and vice versa. Strain rate outside the fault is localized around the fault segment with complex geometry and fault structure. Strain partitioning on the central section of the Xianshuihe-Xiaojiang fault zone is influenced by the interaction between the Anninghe-Zemuhe fault and the Daliangshan fault zone. Striking of the Longmenshan fault zone is nearly orthogonal to the direction of eastward extrusion in the Tibetan Plateau. It leads to low slip rate on the fault zone. | WANG Hui LIU Jie SHEN XuHui LIU Mian LI QingSong SHI YaoLin ZHANG GuoMin | 2010 | Science China Earth Sciences2010，53，7： | 5 |
| 18 | Co-administration of paroxetine and pravastatin causes deregulation of glucose homeostasis in diabetic rats via enhanced paroxetine exposure显示文摘 | Feng LI Mian ZHANG Dan XU Can LIU Ze-yu ZHONG Ling-ling JIA Meng-yue HU Yang YANG Li LIU Xiao-dong LIU | 2014 | Acta Pharmacologica Sinica2014，35，6： | 4 |
| 19 | Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats显示文摘The present study was designed to investigate the effects of Laminaria japonica(Laminaria) on pharmacokinetics of glycyrrhetinic acid(GA) following oral administration of Liquorice extract in rats.Following oral administrations of single-dose and multi-dose Liquorice extract and Liquorice-Laminaria extract,respectively,plasma samples were obtained at various times and the concentrations of GA,liquiritigenin,and isoliquiritigenin were measured by LC-MS.The effects of Laminaria extract on pharmacokinetics of GA were also investigated,following single-dose and multidose of glycyrrhizic acid(GL).The effects of Laminaria extract on intestinal absorption of GA and GL were studied using the in situ single-pass intestinal perfusion model.The metabolism of GL to GA in the contents of small and large intestines was also studied.The results showed Liquorice-Laminaria extract markedly increased the plasma concentration of GA,accompanied by a shorter Tmax.Similar alteration was observed following multidose administration.However,pharmacokinetics of neither liquiritigenin nor isoliquiritigenin was affected by Laminaria.Similarly,Laminaria markedly increased concentration and decreased Tmax of GA following oral GL were observed.The data from the intestinal perfusion model showed that Laminaria markedly increased GL absorption in duodenum and jejunum,but did not affect the intestinal absorption of GA.It was found that Laminaria enhanced the metabolism of GL to GA in large intestine.In conclusion,Laminaria increased plasma exposures of GA following oral administration of liquorice or GL,which partly resulted from increased intestinal absorption of GL and metabolism of GL to GA in large intestine. | ZHAO Wei-Man JIANG Shu-Wen CHEN Yang ZHONG Ze-Yu WANG Zhong-Jian ZHANG Mian LI Ying XU Ping LIU Li LIU Xiao-Dong | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 4 |
| 20 | Long aftershock sequences in North China and Central US: implications for hazard assessment in mid-continents显示文摘Because seismic activity within mid-continents is usually much lower than that along plate boundary zones, even small earthquakes can cause widespread concerns, especially when these events occur in the source regions of previous large earthquakes. However, these small earthquakes may be just aftershocks that continue for decades or even longer. The recent seismicity in the Tangshan region in North China is likely aftershocks of the 1976 Great Tangshan earthquake. The current earthquake sequence in the New Madrid seismic zone in central United States, which includes a cluster of M * 7.0 events in 1811–1812 and a number of similar events in the past millennium, is believed to result from recent fault reactivation that releases pre-stored strain energy in the crust. If so, this earthquake sequence is similar to aftershocks in that the rates of energy release should decay with time and the sequence of earthquakes will eventually end. We use simple physical analysis and numerical simulations to show that the current sequence of large earthquakes in the New Madrid fault zone is likely ending or has ended. Recognizing that mid-continental earthquakes have long aftershock sequences and complex spatiotemporal occurrences are critical to improve hazard assessments. | Mian Liu Gang Luo Hui Wang Seth Stein | 2014 | Earthquake Science2014，27，1： | 4 |
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