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| 1 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 2 | ESCRT-I Component VPS23A Affects ABA Signaling by Recognizing ABA Receptors for Endosomal Degradation显示文摘受体在过去的十年在植物科学成为了很重要的进展之一的 PYR/PYL/RCAR-type abscisic 酸(骆驼毛的织物) 的最近的发现。在哺乳动物,排序的 endosomal 充当一条重要小径到 downregulate 受体的不同类型,而是它在植物荷尔蒙发信号的角色糟糕被理解。这里,我们报导那 ubiquitin 象 E2 一样蛋白质, VPS23A,是 ESCRT-I 的一个关键部件,否定地调整骆驼毛的织物发信号。VPS23A 与 PYR/PYL/RCAR-type 骆驼毛的织物受体和提高的 VPS23A 的混乱有 epistatic 关系在在骆驼毛的织物处理下面表明小径的 ABA 的关键 kinase OST1 的活动。而且, VPS23A 与 PYR1/PYLs 交往,连接 K63 的 diubiquitin,和 PYL4 在 vivo 拥有连接 K63 的 ubiquitinated 修正。进一步的分析表明 VPS23A 影响 PYR1 和 PYL4 的稳定性的 subcellular 本地化。一起拿,我们的结果建议 VPS23A 经由调停液泡的降级影响 PYR1/PYL4,提供两个的先进理解在植物荷尔蒙发信号的骆驼毛的织物受体和 ESCRT 的周转。 | Feifei Yu Lijuan Lou Miaomiao Tian Qingliang Li Yanglin Ding Xiaoqiang Cao Yaorong Wu Borja Belda-Palazon Pedro L. Rodriguez Shuhua Yang Qi Xie | 2016 | Molecular Plant2016，9，12： | 17 |
| 3 | Inhibitor of apoptosis proteins and apoptosis显示文摘Apoptosis 是在多细胞的动物的开发,动态平衡,和有免疫力的防卫起一个关键作用的一个生理的细胞死亡过程。apoptosis 蛋白质(国际机场) 的禁止者组成在一个和三次 baculovirus 国际机场重复之间拥有的蛋白质的一个家庭。他们中的一些也有一个确实有趣的新基因手指领域,并且能由有约束力、禁止的活跃 caspases 阻止房间死亡,但是被国际机场对手调整。一些证据也显示那个国际机场能调制房间周期和信号 transduction。三个主要因素,国际机场,国际机场对手,和 caspases,涉及在许多种类调整 apoptosis 的进步。许多研究和假设集中于在这三个主要因素之间的弯曲相互作用探索他们的真正的功能的模型以便开发潜在的 anticancer 药。在这评论,我们描述国际机场的分类,分子的结构,和性质并且讨论 apoptosis 的机制。我们也在恶意的诊断和治疗讨论国际机场的临床的应用程序的有希望的意义。 | Yunbo Wei Tingjun Fan Miaomiao Yu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 14 |
| 4 | Queue Size Distribution of Geo/G/1 Queue Under the Min(N,D)-Policy显示文摘This paper considers a discrete-time Geo/G/1 queue under the Min(N,D)-policy in which the idle server resumes its service if either N customers accumulate in the system or the total backlog of the service times of the waiting customers exceeds D,whichever occurs first(Min(N,D)-policy).By using renewal process theory and total probability decomposition technique,the authors study the transient and equilibrium properties of the queue length from the beginning of the arbitrary initial state,and obtain both the recursive expression of the z-transformation of the transient queue length distribution and the recursive formula for calculating the steady state queue length at arbitrary time epoch n^+.Meanwhile,the authors obtain the explicit expressions of the additional queue length distribution.Furthermore,the important relations between the steady state queue length distributions at different time epochs n^-,n and n^+ are also reported.Finally,the authors give numerical examples to illustrate the effect of system parameters on the steady state queue length distribution,and also show from numerical results that the expressions of the steady state queue length distribution is important in the system capacity design. | GU Jianxiong WEI Yingyuan TANG Yinghui YU Miaomiao | 2016 | Journal of Systems Science & Complexity2016，29，3： | 12 |
| 5 | Investigating the Transport Mechanism of PM2.5 Pollution during January 2014 in Wuhan, Central China显示文摘Severe haze pollution that occurred in January 2014 in Wuhan was investigated. The factors leading to Wuhan’s PM2.5 pollution and the characteristics and formation mechanism were found to be significantly different from other megacities, like Beijing. Both the growth rates and decline rates of PM2.5 concentrations in Wuhan were lower than those in Beijing, but the monthly PM2.5 value was approximately twice that in Beijing. Furthermore, the sharp increases of PM2.5 concentrations were often accompanied by strong winds. A high-precision modeling system with an online source-tagged method was established to explore the formation mechanism of five haze episodes. The long-range transport of the polluted air masses from the North China Plain (NCP) was the main factor leading to the sharp increases of PM2.5 concentrations in Wuhan, which contributed 53.4% of the monthly PM2.5 concentrations and 38.5% of polluted days. Furthermore, the change in meteorological conditions such as weakened winds and stable weather conditions led to the accumulation of air pollutants in Wuhan after the long-range transport. The contribution from Wuhan and surrounding cities to the PM2.5 concentrations was determined to be 67.4% during this period. Under the complex regional transport of pollutants from surrounding cities, the NCP, East China, and South China, the five episodes resulted in 30 haze days in Wuhan. The findings reveal important roles played by transregional and intercity transport in haze formation in Wuhan. | Miaomiao LU Xiao TANG Zifa WANG Lin WU Xueshun CHEN Shengwen LIANG Hui ZHOU Huangjian WU Ke HU Longjiao SHEN Jia YU Jiang ZHU | 2019 | Advances in Atmospheric Sciences2019，36，11： | 10 |
| 6 | RELIABILITY INDICES OF DISCRETE-TIME Geo^X/G/1 QUEUEING SYSTEM WITH UNRELIABLE SERVICE STATION AND MULTIPLE ADAPTIVE DELAYED VACATIONS显示文摘这篇论文从可靠性研究的观点与不可靠的加油站和多重适应推迟的假期认为排队的分离时间的 GeoX/G/1 是模型。后面的问题将被讨论:1 ) 服务者在在时间 n 的一个概括忙时期的概率;2 ) 加油站在在时间 n 的失败的概率,即,加油站的短暂 unavailability,和加油站的稳定的州的 unavailability;3 ) 加油站失败的期望的数字在时间间隔期间(0, n ] ,并且加油站的稳定的州的失败频率;4 ) 加油站故障在的期望的数字一概括的服务者忙碌时期。最后,作者证明有不可靠的加油站的一些普通分离时间的排队模型是在这篇论文讨论的模型的特殊情况。 | Yinghui TANG Miaomiao YU Xi YUN Shujuan HUANG | 2012 | Journal of Systems Science & Complexity2012，25，6： | 8 |
| 7 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 8 | Geom/G_1,G_2/1/1 REPAIRABLE ERLANG LOSS SYSTEM WITH CATASTROPHE AND SECOND OPTIONAL SERVICE显示文摘这份报纸学习一个单身的服务器有 Bernoulli 到达过程和没有等待的空格的分离时间的厄兰损失系统。在系统的服务者被假定提供服务的二种不同类型,也就是必要、可选的服务,到顾客。在系统的操作期间,大祸的到达将毁坏系统并且同时劝诱顾客立即离开系统。用一种新类型分离增补可变技术,作者获得排队系统的一些性能特征包括不变的可获得性和系统的失败频率,为是闲散的服务器,的不变的可能性忙碌,故障和系统等等的损失概率。由数字例子,最后,作者在几项表演措施上学习系统参数的影响。 | Yinghui TANG Miaomiao YU Cailiang LI | 2011 | Journal of Systems Science & Complexity2011，24，3： | 6 |
| 9 | Review on evolution and evaluation of asphalt pavement structures and materials显示文摘The purpose of this study was to summarize the wide-range literatures on asphalt pavements, explore the evolution of road pavements, analyze typical asphalt pavement structures, highlight current trends in research and industry, and to recommend future areas of research and development. In this research, road pavement evolution was explored from the earliest roads to the modern pavements. A new method was recommended to categorize asphalt pavement materials into the three large families which may be further sub-divided according to their mechanical parameters. A unified asphalt pavement classification(UAPC) method was proposed and the worldwide asphalt pavements could be divided into six types through the new method. Based o n the UAPC method, 1087 asphalt pavement structures were classified and analyzed to explore the asphalt thickness variation. In order to evaluate asphalt pavement performance, the Chinese design specification was employed for analyzing lives of 29 high-volume pavements and 28 low-volume pavements. Through this research, it was found that:(1) in the past 100 years, asphalt pavement materials and structures had been becoming more and more strong;(2) asphalt layer thicknesses were various from 5 to 60 cm and the overall pavement thicknesses were various from 28 to 160 cm;(3) the long-life pavements in the other countries may become'shorter-life' pavements according to the prediction based on the Chinese specification. | Yu Liu Peifeng Su Miaomiao Li Zhanping You Mohan Zhao | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，5： | 6 |
| 10 | The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal β-catenin activation显示文摘Wnt/-catenin 发信号在脊椎动物 embryogenesis 期间为背面腹的 patterning 的开始是必要的。母亲的 -catenin 在劈开阶段期间在背面的边缘的原子核积累,但是它为 dorsalization 的批评目标基因必需品是沉默的直到中间胞胚的转变(MBT ) 。这里,我们发现那 zebrafish net1,一个 guanine 核苷酸交换因素,明确地在 MBT,和行为以后在背面的边缘的分裂球被表示为一个 zygotic 因素支持背面的房间命运的说明。Loss-of-function 和 gain-of-function 实验证明 Net1 的 GEF 活动为在 zebrafish 胚胎和哺乳动物的房间发信号的 Wnt/-catenin 的激活被要求。Net1 分裂并且激活激活在 MBT 以后引起 -catenin 的 S675 的 phosphorylation 的 PAK1 dimers,和 PAK1 kinase,它最终导致下游的目标基因的抄写。在摘要,我们的结果表明调整 Net1 的 -catenin 激活在 zebrafish 开发期间在背面的轴形成起一个关键作用。 | Shi Wei Miaomiao Dai Zhaoting Liu Yuanqing Ma Hanqiao Shang Yu Cao Qiang Wang | 2017 | Cell Research2017，27，2： | 6 |
| 11 | Structure and Anti-influenza A(H1N1) Virus Activity of Three Polysaccharides from Eucheuma denticulatum显示文摘Three polysaccharides(EW,EH and EA) were prepared from a red alga Eucheuma denticulatum by sequential extraction with cold water,hot water and sodium hydroxide water solution.Their monosaccharide compositions,relative molecular mass and structural characterization were determined by gas chromatography,high performance 1iquid chromatography,fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy methods.EW was hybrid ι/κ/ν-carrageenan(70 ι/17κ/13ν-carrabiose),EH was mainly ι-carrageenan,and EA was mainly α-1,4-Glucan(88%) but mixed with small amount of ι-carrageenan(12%).The relative molecular mass of EW,EH and EA was 480,580 and 510 kDa,respectively.The anti-influenza A(H1N1) virus activity of these three polysaccharides was evaluated using the Madin-Darby canine kidney cells model.EW showed good anti-H1N1 virus activity,its IC 50 was 276.5 μg mL-1,and the inhibition rate to H1N1 virus was 52% when its concentration was 250 μg mL-1.The IC 50 of ι-carrageenan EH was 366.4 μg mL-1,whereas EA showed lower anti-H1N1 virus activity(IC 50 >430 μg mL-1).Available data obtained give positive evidence that the hybrid carrageenan EW from Eucheuma denticulatum can be used as potential anti-H1N1 virus inhibitor in future. | YU Guangli LI Miaomiao WANG Wei] LIU Xin ZHAO Xiaoliang LV Youjing LI Guangsheng JIAO Guangling ZHAO Xia | 2012 | Journal of Ocean University of China2012，11，4： | 5 |
| 12 | 3D Network nanostructured NiCoP nanosheets supported on N-doped carbon coated Ni foam as a highly active bifunctional electrocatalyst for hydrogen and oxygen evolution reactions显示文摘 | Miaomiao Tong Lei Wang Peng Yu Xu Liu Honggang Fu | 2018 | Frontiers of Chemical Science and Engineering2018，12，3： | 5 |
| 13 | Development of an Inactivated Iridovirus Vaccine Against Turbot Viral Reddish Body Syndrome显示文摘Turbot(Scophthalmus maximus L.) reddish body iridovirus(TRBIV) was propagated in turbot fin cells(TF cells) and inactivated as the TRBIV vaccine with its protection efficiency evaluated in this study.TF cells were cultured in 10% bovine calf serum(BCS)-containing MEM medium(pH7.0) at 22℃,in which TRBIV propagated to a titer as high as 105.6 TCID50 mL-1.The TRBIV was inactivated with 0.1% formalin and formulated with 0.5% aluminum hydroxide.The inactivated vaccine caused neither cytopathogenic effect(CPE) on TF cells nor pathogenic effect on turbots.After being administered with the vaccine twice via muscle injection,the turbot developed high-tittered TRBIV neutralizing antibodies in a dose-dependent manner.The vaccine protected the turbot from dying with an immunoprotection rate of 83.3% as was determined via subcutaneous vaccination in the laboratory and 90.5% via bath vaccination in turbot farms,respectively.The inactivated vaccine was very immunogenic,efficiently preventing tur-bot from death.It holds the potential of being applied in aquaculture. | FAN Tingjun HU Xiuzhong WANG Liyan GENG Xiaofen JIANG Guojian YANG Xiuxia YU Miaomiao | 2012 | Journal of Ocean University of China2012，11，1： | 5 |
| 14 | ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS Module in Arabidopsis显示文摘The Salt-Overly-Sensitive(SOS)signaling module,comprising the sodium-transport protein SOS1 and the regulatory proteins SOS2 and SOS3,is well known as the central salt excretion system,which helps protect plants against salt stress.Here we report that VPS23A,a component of the ESCRT(endosomal sorting complex required for transport),plays an essential role in the function of the SOS module in conferring plant salt tolerance.VPS23A enhances the interaction of SOS2 and SOS3.In the presence of salt stress,VPS23A positively regulates the redistribution of SOS2 to the plasma membrane,which then activates the antiporter activity of SOS1 to reduce Na+accumulation in plant cells.Genetic evidence demonstrated that plant salt tolerance achieved by the overexpression of SOS2 and SOS3 dependeds on VPS23A.Taken together,our results revealed that VPS23A is a crucial regulator of the SOS module and affects the localization of SOS2 to the cell membrane.Moreover,the strong salt tolerance of Arabidopsis seedlings conferred by the engineered membrane-bound SOS2 revealed the significance of SOS2 sorting to the cell membrane in achieving its function,providing a potential strategy for crop salt tolerance engineering. | Lijuan Lou Feifei Yu Miaomiao Tian Guangchao Liu Yaorong Wu Yujiao Wu Ran Xia Jose M.Pardo Yan Guo Qi Xie | 2020 | Molecular Plant2020，13，8： | 5 |
| 15 | Efficacy of Qingre Huashi decoction(清热化湿方) on infection of Helicobacter pylori:inhibiting adhesion,antioxidant,and anti-inflammation显示文摘OBJECTIVE: To investigate the phytochemical profile of Qingre Huashi decoction( 清 热 化 湿 方, QHD) and evaluate the mechanisms rationalizing the use of QHD against Helicobacter pylori(H. pylori)-associated gastritis. METHODS: QHD is composed of 11 herbs, which was prepared by a fixed Pharmacy and concentrated into clear paste. High-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(HPLC-QTOF/MS) was used to detect the phytochemical profile of QHD. The toxicity of QHD against H. pylori and human gastric epithelial cells was evaluated by the toxicology test and cell counting kit-8 assay. The adhesion model was constructed by incubating H. pylori and gastric mucosal epithelial cells for 2 h. The urease assay was used to examine the antiadhesion effects of QHD, and gene expression of adhesins was evaluated by quantitative polymerase chain reaction. The antioxidant activity was assessed by DCFHDA labeling. To evaluate the anti-inflammatory effect, the levels of pro-inflammatory cytokines in the culture supernatant were detected by enzyme-linked immunosorbent assay. RESULTS: HPLC-QTOF/MS profiling indicated the presence of primary compounds 1-20 in QHD. Drug concentration was determined as 1, 2, and 5 mg/m L by the toxic concentration of QHD against H. pylori and human gastric epithelial cells. QHD prevented H. pylori adhesion to the human gastric epithelial cells and reduced levels of reactive oxygen species. QHD also reduced the level of interleukin-8 and other proinflammatory cytokines that were upregulated by H. pylori infection. CONCLUSION: QHD could inhibit H. pylori adhesion, and exert antioxidant and anti-inflammatory effects in vitro. | HUANG Qiuyue YE Hui SHI Zongming JIA Xiaofen LIN Miaomiao CHU Yingming YU Jing ZHANG Xuezhi | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 3 |
| 16 | Preparation of κ-carra-Oligosaccharides with Microwave Assisted Acid Hydrolysis Method显示文摘A rapid method of microwave assisted acid hydrolysis was established to prepare κ-carra-oligosaccharides. The optimal hydrolysis condition was determined by an orthogonal test. The degree of polymerization(DP) of oligosaccharides was detected by high performance thin layer chromatography(HPTLC) and polyacrylamide gel electrophoresis(PAGE). Considering the results of HPTLC and PAGE, the optimum condition of microwave assisted acid hydrolysis was determined. The concentration of κ-carrageenan was 5 mg m L-1; the reaction solution was adjusted to p H 3 with diluted hydrochloric acid; the solution was hydrolyzed under microwave irradiation at 100 for 15℃ min. Oligosaccharides were separated by a Superdex 30 column(2.6 cm × 90 cm) using AKTA Purifier UPC100 and detected with an online refractive index detector. Each fraction was characterized by electrospray ionization mass spectrometry(ESI-MS). The data showed that odd-numbered κ-carra-oligosaccharides with DP ranging from 3 to 21 could be obtained with this method, and the structures of the oligosaccharides were consistent with those obtained by traditional mild acid hydrolysis. The new method was more convenient, efficient and environment-friendly than traditional mild acid hydrolysis. Our results provided a useful reference for the preparation of oligosaccharides from other polysaccharides. | LI Guangsheng ZHAO Xia LV Youjing LI Miaomiao YU Guangli | 2015 | Journal of Ocean University of China2015，14，2： | 3 |
| 17 | Community-Based Management and Treatment Services for Psychosis-China, 2019显示文摘Introduction:Community-based services for psychosis are an important part of mental health services in China.We analyzed community-based follow-up and treatment services for psychosis in China in 2019 to provide evidence for policymaking and services delivering.Methods:Data from the National Information System for Psychosis were used to analyze usage of the information system and the registration,management,and treatment situation of patients with psychosis in China in 2019 and compared the results of 2019 with that of 2018.Results:In 2019,100%of cities and counties used the information system and 6,230,157 patients were registered.In 2019,there were 5,944,724 registered patients(94.05%)in China under community-based follow-up services and 5,375,252 patients(85.04%)had regular follow-ups;5,295,657 patients(83.78%)were treated by taking antipsychotics and 3,354,251(53.07%)patients took medication regularly;4,974,314 patients at home(87.81%)were in stable condition;and there was a significant difference in patients’stable condition and medication-taking rates among eastern,central,and western regions(p<0.05).Compared with 2018,the nationwide regular management rate,medication-taking rate,regular medication-taking rate,and patients’stable rate increased by 2.35%,2.48%,11.29%,and 7.21%respectively.Conclusions and Implications for Public Health Practice:Compared with 2018,the level of management and treatment improved significantly but still needs to be further strengthened,especially in western China. | Miaomiao Zhao Ning Ma Xun Wang Xiamin Wu Wufang Zhang Runzi Chen Yulu Wang Lili Guan Hong Ma Xin Yu Lin Lu | 2020 | China CDC weekly2020，2，41： | 3 |
| 18 | Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells显示文摘The p21 activated kinase 4(PAK4) is serine/threonine protein kinase that is critical for cancer progression.Guided by X-ray crystallography and structure-based optimization,we report a novel subseries of C-3-substituted 6-ethynyl-1 H-indole derivatives that display high potential and specificity towards group Ⅱ PAKs.Among these inhibitors,compound 55 exhibited excellent inhibitory activity and kinase selectivity,displayed superior anti-migratory and anti-invasive properties against the lung cancer cell line A549 and the melanoma cell line B16.Compound 55 exhibited potent in vivo antitumor metastatic efficacy,with over 80% and 90% inhibition of lung metastasis in A549 or B16-BL6 lung metastasis models,respectively.Further mechanistic studies demonstrated that compound 55 mitigated TGF-β1-induced epithelial-mesenchymal transition(EMT). | Peilu Song Fan Zhao Dahong Li Jiqiang Qu Miao Yao Yuan Su Hanxun Wang Miaomiao Zhou Yujie Wang Yinli Gao Feng Li Dongmei Zhao Fengjiao Zhang Yu Rao Mingyu Xia Haitao Li Jian Wang Maosheng Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 19 | Purification and characterization of phenoloxidase from brine shrimp Artemia sinica显示文摘从 Artemia sinica (AsPO ) 的 Phenoloxidase 被 Superdex 200 胶化过滤和 Q Sepharose 快流动离子交换层析净化,并且它的性质被把 L-dihydroxyphenylalanine (L-DOPA ) 用作特定的底层生物化学地并且酶地描绘。结果证明 AsPO 在分子的质量中作为 125.5 kDa 的 monomeric 蛋白质被孤立。最佳的 pH 价值和温度是 7.0 并且 50uronidase ) GhHyPRP4 倡导者驾驶的基因明确地在转基因的 Arabidopsis thaliana 的叶子和子叶被表示。而且,在叶子的 GUS 表示被冷应力显著地导致。在酵母(Schizosaccharomyces pombe ) 的 GhHyPRP4 的 Overexpression 显著地没有乙醇在食物上在 20d 消费下面在处理之上提高了房间幸存率;当食物包含了 0.01, 0.3,或 0.5% 时,他们没改变消费乙醇;但是显著地?? | Tingjun Fan Zhao Jing Xianyuan Fan Miaomiao Yu Guojian Jiang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 2 |
| 20 | Multi-antenna synchronized global navigation satellite system receiver and its advantages in high-precision positioning applications显示文摘 | Danan DONG Wen CHEN Miaomiao CAI Feng ZHOU Minghua WANG Chao YU Zhengqi ZHENG Yuanfei WANG | 2016 | Frontiers of Earth Science2016，10，4： | 2 |
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