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227篇 您的检索式:作者名="Michael W T"
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1Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field.Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong 2021World Journal of Gastroenterology2021,27,40:6
2临床意义上的前列腺癌的预测标准化:可能吗?显示文摘近几十年来,对前列腺癌的生物学和流行病学的深入研究已经使前列腺癌的治疗取得了很大进展。很多前列腺癌可以在发病早期被发现,并且有多种有效的治疗手段。然而,仍无明确的数据表明这些早期诊断和治疗能够有效地控制前列腺癌的死亡率。这可能是由于接受治疗的一大部分癌症患者的恶性程度较低,即使不予治疗亦不会对患者的健康和生存期产生影响。基于过度治疗现象的存在,在当代的医疗过程中,积极监测以观后效被认为是一种有效的治疗方式。如何区别不具临床意义的肿瘤与高度恶性、高致死率的肿瘤,对为患者选择积极监测还是立即干预的治疗方案来说至关重要。本章节总结了风险分组和列线图等多种预测模型对于低度恶性肿瘤的预测能力及它们在局限性前列腺癌的治疗中所起的作用。Carver T Nguyen Michael W Kattan 2012Asian Journal of Andrology2012,14,3:3
3Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) 2006英国医学杂志中文版2006,9,5:3
4一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) 2009世界临床医学2009,,9:2
5继发性腹膜炎:诊断和干预原则显示文摘继发性腹膜炎的患者占急诊入院患者总数的1%。在全球范围内,继发性腹膜炎是重症监护病房(ICU)发生脓毒症的第二大原因。继发性腹膜炎的总体病死率是6%,但是当患者发展成为严重脓毒症时,其病死率上升为35%O尽管影像学和实验室检查日益普及,但是对于急诊、外科和ICU医生来说,如何快速诊断和早期处理腹膜炎仍然是一个难题。本文将综述腹膜炎的病理生理学机制以及发展为脓毒症的过程,我们还讨论了物理检查、实验室检查和影像学检查在诊断继发性腹膜炎中的有效性和局限性,并且提出一个治疗继发性腹膜炎的思路。James T Ross Michael A Matthay Hobart W Harris 陈国榕(译) 吴东(校) 2019英国医学杂志中文版2019,22,7:2
6High-performance thin-layer chromatographic determination of deoxynivalenol,fusarenon-X and nivalenol in barley,corn and wheat显示文摘MARY W T MICHAEL T F MAGDI M M 1987Agriculture and Food Chemistry1987,35,4:1
7Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H 2008Plant Physiology2008,147,2:1
8Treatment and long - term management of Kawasaki disease 显示文摘Jane W Masato T Michael A 2004Circulation2004,110,:1
9Differences in replication of a DNA template containing an ethyl phosphotriester by T4 DNA polymerase and Escherichia coli DNA polymerase I显示文摘Laura T Michael W Linda J 0,,17:1
10Hepatitis C virus treatment in the real world: optimising treatment and access to therapies显示文摘Zoulim Fabien Liang T Jake Gerbes Alexander L Aghemo Alessio Deuffic-Burban Sylvie Dusheiko Geoffrey Fried Michael W Pol Stanislas Rockstroh Ju?rgen Kurt Terrault Norah A Wiktor Stefan 2015Gut2015,,11:1
11UVA and UVB radiation differentially regulate vascular endothelial growth factor expression in Keratinocyte-derived cell lines and in human keratinocytes显示文摘Michael M Wolfgang W Franz T 1999Photochemistry and Photobiology1999,70,4:1
12Persistence of soil organic matter as an e- cosystem property显示文摘Michael W I S Margaret S T Samuel A 2011Nature2011,478,7367:1
13Monte Carlo Model- ing of Light Propagation in Highly Scattering Tissues-II : Compari- son with Measurements in Phantom 显示文摘FLOCK S T BRIAN C W MICHAEL S P 1989IEEE Transactions on Biomedical Engineering1989,36,:1
14A longitudinal study oral ulcerative mucositis in bone marrow transplant recipients显示文摘Sook-Bin W Stephen T Michael M 1993Cacer1993,72,5:1
15Human prostatic smooth muscle cells in culture:estradiol enhances expres-sion of smooth muscle specific markers显示文摘Zhang J Michael W H Martin T 1997The Prostate1997,30,:1
16An Efficient Asymmetric Approach to Carbocyclic Nucleosides:Asymmetric Synthesis of 1592U89,a Potent Inhibitor of HIV Reverse Transcriptase显示文摘Michael T C Bryan W K 1996J Org Chem1996,61,:1
17A longitudinal study of oral uralulcerative mucositis in bone marrow transplant recipi- ents 显示文摘Sook-Bin W Stephen T Michael M 1993Caneer1993,72,5:1
18Extented-aperture Underwa-ter Acoustic Multisource Azimuth/elevation Direction-fioding Using Uniformly but Sparsely Spaced Vector Hy-drophones显示文摘Kainam T W Michaell D Z 1997IEEE Oceanic Engineering1997,22,4:1
19Active contour models显示文摘MICHAEL K ANDRE W DEMETRI T 1987International Journal of Computer Vision1987,1,4:1
20Recent results on themass,gravitational field and moments of inertia of theMoon显示文摘Michael W H Blackshear W T 1972Moon1972,,3:1
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