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1篇 您的检索式:作者名="Michele Chicone"
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1Overview of angiogenesis and oxidative stress in cancer显示文摘Neoplasms can be considered as a group of aberrant cells that need more vascular supply to fulfill all their functions.Therefore,they promote angiogenesis through the same neovascularization pathway used physiologically.Angiogenesis is a process characterized by a heterogeneous distribution of oxygen caused by the tumor and oxidative stress;the latter being one of the most powerful stimuli of angiogenesis.As a result of altered tumor metabolism due to hypoxia,acidosis occurs.The angiogenic process and oxidative stress can be detected by measuring serum and tissue biomarkers.The study of the mechanisms underlying angiogenesis and oxidative stress could lead to the identification of new biomarkers,ameliorating the selection of patients with neoplasms and the prediction of their response to possible anti-tumor therapies.In particular,in the treatment of patients with similar clinical tumor phenotypes but different prognoses,the new biomarkers could be useful.Moreover,they may lead to a better understanding of the mechanisms underlying drug resistance.Experimental studies show that blocking the vascular supply results in antiproliferative activity in vivo in neuroendocrine tumor cells,which require a high vascular supply.Luigi Gaetano Andriolo Vittoria Cammisotto Alessandra Spagnoli Danilo Alunni Fegatelli Michele Chicone Gaetano Di Rienzo Vladimiro Dell’Anna Giambattista Lobreglio Giovanni Serio Pasquale Pignatelli 2023World Journal of Meta-Analysis2023,11,6:1
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