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| 1 | Schisandrin B decreases the sensitivity of mitochondria to calcium ioninduced permeability transition and protects against ischemia-reperfusion injury in rat hearts显示文摘瞄准:为了阐明,位于 cardioprotection 下面的分子的机制由 schisandrin 负担得起 B (Sch B ) ,到刺激 Ca2+ 的渗透转变(磅) 的线粒体的敏感上的 Sch B 处理的效果在正常和 ischemia-reperfusion (红外) 条件下面在老鼠心被调查。结果:心肌的红外损害在线粒体的敏感引起了增加到刺激 Ca2+ 的磅在试管内。到 mitochondrial 磅的提高的敏感与 mitochondrial Ca2+ 内容以及反应氧化剂的程度的增加被联系种类生产在试管内和细胞色素 c 版本在活体内。Sch B 预告的处理对 I-R-induced 损害负担得起的 cardioprotection 是由在到刺激 Ca2+ 的磅的心肌的线粒体的敏感的减少的 paralleled,特别地在红外条件下面。结论:结果建议 Sch B 治疗增加心肌的线粒体的抵抗到刺激 Ca2+ 的磅并且免于 I-R-induced 组织损害。 | Po-yee CHIU Hoi-yan LEUNG Ada HL SIU Michel KTPOON Kam-ming KO | 2007 | Acta Pharmacologica Sinica2007，28，10： | 12 |
| 2 | Intra-project externality and layout variables in residential condominium appraisals 显示文摘 | Han Su S-H Michelle Chu George H L Ko W | 1998 | Journal of Real Estate Research1998，15，2： | 1 |
| 3 | Recent advances in re- search on carbon nanotube-polymer composites 显示文摘 | Michele T Byrne Yurii K Gun' ko | 2010 | Adv Mater2010，22，： | 1 |
| 4 | Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications显示文摘 | Paul Galvin Damien Thompson Katie B. Ryan Anna McCarthy Anne C. Moore Conor S. Burke Maya Dyson Brian D. MacCraith Yurii K. Gun’ko Michelle T. Byrne Yuri Volkov Chris Keely Enda Keehan Michael Howe Conor Duffy Ronan MacLoughlin | 2012 | Cellular and Molecular Life Sciences2012，，3： | 1 |
| 5 | Alterations in tissue glutathione antioxidant system in streptozotocin-induced diabetic rats显示文摘 | Duncan H. F. Mak Siu Po Ip Pui Chun Li Michel K. T. Poon Kam Ming Ko | 1996 | Molecular and Cellular Biochemistry1996，，2： | 1 |
| 6 | Recent advances in research on carbon nanotube polymer composites显示文摘 | Michele T B Yurii K Gun' ko | 2010 | Adv Mater2010，22，15： | 1 |
| 7 | Chronic schisandrin B treatment improves mitochondrial antioxidant status and tissue heat shock protein production in various tissues of young adult and middle-aged rats显示文摘 | Po Yee Chiu Hoi Yan Leung Michel K. T. Poon Kam Ming Ko | 2006 | Biogerontology2006，，4： | 1 |
| 8 | Increasing Age and Survival after Orthotopic Liver Transplantation for Patients with Hepatocellular Cancer显示文摘 | Joseph Kim Michelle E. Ko Rebecca A. Nelson Amanda Arrington Carrie Luu Ann E. Falor Nicholas N. Nissen Steven Colquhoun Arti Hurria Gagandeep Singh | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 9 | Active drainage combined with air-fluid exchange for silicone oil removal:advantages and longterm follow-up 显示文摘 | Michel G Meyer L Naoun KO | 2008 | J Fr Ophthalmol2008，31，8： | 1 |
| 10 | Accuracy of computed tomography in nodal staging of colon cancer patients显示文摘AIM: To predict node-positive disease in colon cancer using computed tomography(CT).METHODS: American Joint Committee on Cancer stage Ⅰ-Ⅲ colon cancer patients who underwent curavtiveintent colectomy between 2007-2010 were identified at a single comprehensive cancer center. All patients had preoperative CT scans with original radiology reports from referring institutions. CT images underwent blinded secondary review by a surgeon and a dedicated abdominal radiologist at our institution to identify pericolonic lymph nodes(LNs). Comparison of outside CT reports to our independent imaging review was performed in order to highlight differences in detection in actual clinical practice. CT reviews were compared with final pathology. Results of the outside radiologist review, secondary radiologist review, and surgeon review were compared with the final pathologic exam to determine sensitivity, specificity, positive and negative predictive values, false positive and negative rates, and accuracy of each review. Exclusion criteria included evidenceof metastatic disease on CT, rectal or appendiceal involvement, or absence of accompanying imaging from referring institutions.RESULTS: From 2007 to 2010, 64 stageⅠ-Ⅲ colon cancer patients met the eligibility criteria of our study. The mean age of the cohort was 68 years, and 26(41%) patients were male and 38(59%) patients were female. On final pathology, 26 of 64(40.6%) patients had nodepositive(LN+) disease and 38 of 64(59.4%) patients had node-negative(LN-) disease. Outside radiologic review demonstrated sensitivity of 54%(14 of 26 patients) and specificity of 66%(25 of 38 patients) in predicting LN+ disease, whereas secondary radiologist review demonstrated 88%(23 of 26) sensitivity and 58%(22 of 38) specificity. On surgeon review, sensitivity was 69%(18 of 26) with 66% specificity(25 of 38). Secondary radiology review demonstrated the highest accuracy(70%) and the lowest false negative rate(12%), compared to the surgeon review at 67% accuracy and 31% false negative rate and the outside radiology review at 61% accuracy and 46% false negative rate.CONCLUSION: CT LN staging of colon cancer has moderate accuracy, with administration of NCT based on CT potentially resulting in overtreatment. Active search for LN+ may improve sensitivity at the cost of specificity. | Audrey H Choi Rebecca A Nelson Hans F Schoellhammer Won Cho Michelle Ko Amanda Arrington Christopher R Oxner Marwan Fakih Jimmie Wong Stephen M Sentovich Julio Garcia-Aguilar Joseph Kim | 2015 | World Journal of Gastrointestinal Surgery2015，7，7： | 0 |
| 11 | 与 resectable 在病人化疗和幸存预定胃的腺癌显示文摘 AIM: To evaluate the timing of chemotherapy in gastric cancer by comparing survival outcomes in treatment groups. METHODS: Patients with surgically resected gastric adenocarcinoma from 1988 to 2006 were identified from the Los Angeles County Cancer Surveillance Program. To evaluate the population most likely to receive and/or benefit from adjunct chemotherapy, inclusion criteria consisted of Stage Ⅱ or Ⅲ gastric cancer patients > 18 years of age who underwent curative-intentsurgical resection. Patients were categorized into three groups according to the receipt of chemotherapy:(1) no chemotherapy;(2) preoperative chemotherapy; or(3) postoperative chemotherapy. Clinical and pathologic characteristics were compared across the different treatment arms.RESULTS: Of 1518 patients with surgically resected gastric cancer, 327(21.5%) received perioperative chemotherapy. The majority of these 327 patients were male(68%) with a mean age of 61.5 years; and they were significantly younger than non-chemotherapy patients(mean age, 70.7; P < 0.001). Most patients had tumors frequently located in the distal stomach(34.5%). Preoperative chemotherapy was administered to 11.3% of patients(n = 37) and postoperative therapy to 88.7% of patients(n = 290). An overall survival benefit according to timing of chemotherapy was not observed on univariate or multivariate analysis. Similar results were observed with stagespecific survival analyses(5-year overall survival: Stage Ⅱ, 25% vs 30%, respectively; Stage Ⅲ, 14% vs 11%, respectively). Therefore, our results do not identify a survival advantage for specific timing of chemotherapy in locally advanced gastric cancer. CONCLUSION: This study supports the implementation of a randomized trial comparing the timing of perioperative therapy in patients with locally advanced gastric cancer. | Amanda K Arrington Rebecca Nelson Supriya S Patel Carrie Luu Michelle Ko Julio Garcia-Aguilar Joseph Kim | 2013 | World Journal of Gastrointestinal Surgery2013，5，12： | 0 |
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