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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Application of grain size trend analysis for the determination of sediment transport pathways in intertidal areas 显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine geology1996，135，： | 2 |
| 3 | Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE)显示文摘 | Alicia Amigou Jérémie Rudant Laurent Orsi Stéphanie Goujon-Bellec Guy Leverger André Baruchel Yves Bertrand Brigitte Nelken Geneviève Plat Gérard Michel Stéphanie Haouy Pascal Chastagner Stéphane Ducassou Xavier Rialland Denis Hémon Jacqueline Clavel | 2012 | Cancer Causes & Control2012，，8： | 2 |
| 4 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 5 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 6 | Use of plasmid DNA for direct gene transfer and immunization显示文摘 | Davis H L Michel M L Whalen R G | 1995 | NY Acad Sci1995，772，： | 1 |
| 7 | Application of grain size trend analysis for the determination of sediment transport pathways in intertidal areas显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine Geology1996，135，： | 1 |
| 8 | The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice显示文摘 | Michele M H Theresa R Wang T | 2010 | J Clin Invest2010，120，3： | 1 |
| 9 | High-Resolution Surface-wave tomography from Ambient Seismic Noise显示文摘 | Nikolai M S Michel C Laurent S Michael H R | 2005 | Science2005，307，5715： | 1 |
| 10 | Application of grain size trend analysis for the determination of sediment transport pathways in intertidal areas 显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine Geology1996，135，： | 1 |
| 11 | Fritschel chemical characterizationg of fresh kill landfill refuse and extracts显示文摘 | ROBERT K H MICHELE R N PAUL F | 1993 | Jourmal of Environmental Engineering1993，119，6： | 1 |
| 12 | Conformity to sex-typed norms, affect, and the self-concept显示文摘 | WENDY W P NIELS C MICHELLE R H | 1997 | Journal of Prsonality and Social Psychology1997，73，3： | 1 |
| 13 | Root distribution of two tree species under a heterogeneous nutrient environment显示文摘 | MOU P MICHELL R J JONES R H | 1997 | J Appl Ecol1997，34，： | 1 |
| 14 | Applicationof grain size trend analysis for the deermination of sediment transport pathways in intertidal areas显示文摘 | Pedreros R Howa H L Michel D | 1996 | Marine Geology1996，135，： | 1 |
| 15 | Combustion synthesis of metallic foams from nanocomposite reactants 显示文摘 | Emily M H Michelle L P Jouet R J | 2006 | Intermetallics2006，14，6： | 1 |
| 16 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 17 | Reactions on mineral dust 显示文摘 | Usher C R Michel A E Grassian V H | 2003 | Chemical Review2003，103，： | 1 |
| 18 | Root distribution of two tree species under a heterogeneous nutrient environment显示文摘 | MOU P MICHELL R J JONES R H | 1997 | J Appli Ecol1997，34，： | 1 |
| 19 | A double - hlind multi- center comparison of the efficacy and safety of saruplase and urokinase in the treatment of acute myocardial infarction : Report of the SUTAMI Study 显示文摘 | Michels R Hoffmann H Windeler J | 1995 | J Thromb Thrombolysis1995，2，2： | 1 |
| 20 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
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