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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Robust face recognition for uncontrolled pose and illumination chan- ges显示文摘 | Maria D M Michele N Daniel R | 2013 | 1EEE Transactions on Systems Man and Cy- bernetics: Systems2013，43，1： | 1 |
| 3 | Transplantation of cultured explants of human endometrium into nude mice显示文摘 | Michelle N Franoise R Etienne M | 2000 | Hum Repod2000，15，3： | 1 |
| 4 | Fritschel chemical characterizationg of fresh kill landfill refuse and extracts显示文摘 | ROBERT K H MICHELE R N PAUL F | 1993 | Jourmal of Environmental Engineering1993，119，6： | 1 |
| 5 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 6 | Quantizer effects on steady-state error specification of digital feedback control systems显示文摘 | MILLER R K MICHEL A N FARRELL J A | 1989 | IEEE Transactions on Automatic Control1989，34，6： | 1 |
| 7 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 8 | Stability of viscoelastic control systems显示文摘 | MICHEL A N MILLER R K | 1988 | IEEE Transactions on Automatic Control1988，3，4： | 1 |
| 9 | Study of line source characteristics for 2-D physical modelling of pollutant dispersion in street canyons显示文摘 | ROBERT N M MICHEL P STILIANOS R MICHAEL S | 1996 | Journal of Wind Engineering and Industrial Aerodynamics1996，62，： | 1 |
| 10 | Role of replication and CpG methylation in fragile X syndrome CGG Deletions in primate cells显示文摘 | Kerrie N E Michelle R L Christopher E P | 2005 | Am Hum Genet2005，76，： | 1 |
| 11 | cDNA cloning of bradykinin-potentiating peptides-C-type natriuretic peptide precursor,and characterization of the novel peptide Leu3-blomhotin from the venom of Agkistrodon blomhoffi显示文摘 | Murayama N Michel GH Yanoshita R | 2000 | Eur J Biochem2000，267，13： | 1 |
| 12 | Time-domain Analysis Coupled Transmission Line显示文摘 | GRIFFITH J R MICHEL S N | 1990 | IEEE Transactions on Mi- crowave Theory and Techniques1990，38，10： | 1 |
| 13 | Characterization of a new tissue-engineered human skin equivalent with hair 显示文摘 | Michel M Hcureux N Pouliot R | 1999 | In Vitro Cell Dev Biol Anim1999，35，6： | 1 |
| 14 | Breast milk retinol concentrations are not associated with systemic inflammation among breast-feeding women in Malawi显示文摘 | BARBARA D VERONIQUE N MICHELLE O R | 2005 | Journal of Nutrition2005，135，： | 1 |
| 15 | Quantizer effects on steady-state error specifications of digital feedback control systems显示文摘 | Miller R K Michel A N Farrell J A | 1989 | IEEE Trans on Automatic Control1989，34，6： | 1 |
| 16 | Fritschel chemical characterization of fresh kills landfill refuse and extracts 显示文摘 | Robert K H Michele R N Paul F | 1952 | Journal of Enviromnental Engineering Division1952，108，4： | 1 |
| 17 | Post-traumatic peripher- al facial nerve palsy:surgical and neuroradiological consideration in five cases of delayed onset 显示文摘 | Michele R Raffaele DA Massimo N | 2010 | Acta Neurochirurgica2010，152，： | 1 |
| 18 | 查看详情显示文摘 | Sun R Dong P Feng N N Hong C Y Michel J Lipson M Kimer-ling L | | 0，，： | 1 |
| 19 | Characterization of anew tissue -engineered human skin equivalent with hair 显示文摘 | Michel M L’heureux N Pouliot R | 1999 | InVitro Cell Dev Biol Anim1999，35，6： | 1 |
| 20 | Membrane lipid peroxidation in copper alloy-mediated contact killing of Escherichia coli显示文摘 | Hong R Kang TY Michels CA Gadura N | 2012 | Appl Environ Microbiol2012，78，6： | 1 |
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