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3篇 您的检索式：作者名="Michelle Torregrossa"

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		题名	作者	年代	出处	被引量
	1	Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.	Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz	2021	Bioactive Materials2021，6，12：	7
	2	The role of fouling mechanisms in a submerged membrane bioreactor during the start-up 显示文摘	Gaetano Di Bella Francesca Durante Michele Torregrossa	2006	Desalination2006，，200：	1
	3	连续油管完整性监测和管理显示文摘连续油管在起下钻期间易于磨损和疲劳。一种新型井场扫描系统通过连续监测油管的异常情况帮助作业公司最大限度地减少油管过早损坏问题。钻井和增产技术的进步正在为非常规资源的开发勘探新的油气远景区。这些远景区的成功开发在很大程度上取决于作业公司最大限度地增加井眼与油气藏的接触面积并开采油气藏的能力。	Rich Christie Zhanke Liu Roderic Stanley Michelle Torregrossa Andrew Zheng Liam Zsolt	2016	国外测井技术2016，37，2：	0

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