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| 1 | Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats显示文摘AIM:To determine the temporal expression and pattern of Rel/nuclear factor(NF)-κB proteins in renal tissue in polycystic kidney disease(PKD). METHODS: The renal expression of Rel/NF-κB proteins was determined by immunohistochemistry, immunofluorescence and immunoblot analysis in Lewis polycystic kidney rats(LPK, a genetic ortholog of human nephronopthsis-9) from postnatal weeks 3 to 20. At each timepoint, renal disease progression and the mR NA expression of NF-κB-dependent genes(TNFa and CCL2) were determined. NF-κB was also histologicaly assessed in human PKD tissue.RESULTS: Progressive kidney enlargement in LPK rats was accompanied by increased renal cell proliferation and interstitial monocyte accumulation(peaking at weeks 3 and 10 respectively), and progressive interstitial fibrosis(with a smooth muscle actin and Sirius Red deposition significantly increased compared to Lewis kidneys from weeks 3 to 6 onwards). Rel/NF-κB proteins(phosphorylated-p105, p65, p50, c-Rel and RelB) were expressed in cystic epithelial cells(CECs) of LPK kidneys as early as postnatal week 3 and sustained until latestage disease at week 20. From weeks 10 to 20, nuclear p65, p50, Rel B and cytoplasmic IκBa protein levels, and TNFa and CCL2 expression, were upregulated in LPK compared to Lewis kidneys. NF-κB proteins were consistently expressed in CECs of human PKD. The DNA damage marker γ-H2AX was also identified in the CECs of LPK and human polycystic kidneys. CONCLUSION: Several NF-κB proteins are consistently expressed in CECs in human and experimental PKD. These data suggest that the upregulation of both the canonical and non-canonical pathways of NF-κB signaling may be a constitutive and early pathological feature of cystic renal diseases. | Michelle HT Ta Kristina G Schwensen David Liuwantara David L Huso Terry Watnick Gopala K Rangan | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 2 | Effects of temperature and humidity on the efficacy of methicillin - resistant Staphylococcus aureus challenged antimicrebial materials containing silver and copper显示文摘 | Michels HT Noyce JO Keevil CW | 2009 | Lett Appl Microbiol2009，49，2： | 1 |
| 3 | Low-dose aspirin may preent growth and later surgical repair of medium-sized abdominal aortic aneurysms显示文摘 | Lindholt JS Sorensen HT Michel JB | 2008 | ascular Endoascular Surg2008，42，4： | 1 |
| 4 | Survival of Clostridium diffi- cile on copper and steel: futuristic options for hospital hygiene 显示文摘 | Weaver L Michels HT Keevil CW | 2008 | J Hosp Infect2008，68，2： | 1 |
| 5 | Biocidal efficacy of copper alloys against pathogenic enterococci involves degradation of genomic and plasmid DNAs 显示文摘 | Warnes SL Green SM Michels HT | 2010 | Appl Environ Microbiol2010，76，16： | 1 |
| 6 | Potential for preventing spread of fungi in air - conditioning systems constructed using copper instead of aluminium 显示文摘 | Weaver L Michels HT Keevil CW | 2010 | Lett Appl Microbiol2010，50，1： | 1 |
| 7 | Phase resetting of the mammalian circadian clock relies on a rapid shift of a small population of pacemaker neurons 显示文摘 | Rohling JH vanderLeest HT Michel S | 2011 | PLoS One2011，6，25： | 1 |
| 8 | Survival of Listeria monocytogenes Scott A on metal surfaces: implications for cross-contamination显示文摘 | Wilks SA Michels HT Keevil CW | 2006 | International Journal of Food Microbiology2006，111，2： | 1 |
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