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| 1 | Pathological aspects of so called 'hilar cholangiocarcinoma'显示文摘Cholangiocarcinoma(CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group.However,'hilar and perihilar CC' are also used to refer exclusively to the intrahepatic hilar type CC or,more commonly,the extrahepatic hilar CC.Grossly,a major distinction can be made between papillary and non-papillary tumors.Histologically,most hilar CCs are well to moderately differentiated conventional type(biliary) carcinomas.Immunohistochemically,CK7,CK20,CEA and MUC1 are normally expressed,being MUC2 positive in less than 50% of cases.Two main premalignant lesions are known:biliary intraepithelial neoplasia(BilIN) and intraductal papillary neoplasm of the biliary tract(IPNB).IPNB includes the lesions previously named biliary papillomatosis and papillary carcinoma.A series of 29 resected hilar CC from our archives is reviewed.Most(82.8%) were conventional type adenocarcinomas,mostly well to moderately differentiated,although with a broad morphological spectrum;three cases exhibited a poorly differentiated cell component resembling signet ring cells.IPNB was observed in 5(17.2%),four of them with an associated invasive carcinoma.A clear cell type carcinoma,an adenosquamous carcinoma and two gastric foveolar type carcinomas were observed. | Víctor M Castellano-Megías Carolina Ibarrola-de Andrés Francisco Colina-Ruizdelgado | 2013 | World Journal of Gastrointestinal Oncology2013，5，7： | 8 |
| 2 | Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas显示文摘Intraductal papillary mucinous neoplasm(IPMN) of the pancreas is a noninvasive epithelial neoplasm of mucinproducing cells arising in the main duct(MD) and/or branch ducts(BD) of the pancreas.Involved ducts are dilated and filled with neoplastic papillae and mucus in variable intensity.IPMN lacks ovarian-type stroma,unlike mucinous cystic neoplasm,and is defined as a grossly visible entity(≥ 5 mm),unlike pancreatic intraepithelial neoplasm.With the use of high-resolution imaging techniques,very small IPMNs are increasingly being identified.Most IPMNs are solitary and located in the pancreatic head,although 20%-40% are multifocal.Macroscopic classification in MD type,BD type and mixed or combined type reflects biological differences with important prognostic and preoperative clinical management implications.Based on cytoarchitectural atypia,IPMN is classified into low-grade,intermediategrade and high-grade dysplasia.Based on histological features and mucin(MUC) immunophenotype,IPMNs are classified into gastric,intestinal,pancreatobiliary and oncocytic types.These different phenotypes can be observed together,with the IPMN classified according to the predominant type.Two pathways have been suggested:gastric phenotype corresponds to less aggressive uncommitted cells(MUC1-,MUC2-,MUC5 AC +,MUC6 +) with the capacity to evolve to intestinal phenotype(intestinal pathway)(MUC1-,MUC2 +,MUC5 AC +,MUC6- or weak +) or pancreatobiliary /oncocytic phenotypes(pyloropancreatic pathway)(MUC1 +,MUC 2-,MUC5 AC +,MUC 6 +) becoming more aggressive.Prognosis of IPMN is excellent but critically worsens when invasive carcinoma arises(about 40% of IPMNs),except in some cases of minimal invasion.The clinical challenge is to establish which IPMNs should be removed because of their higher risk of developing invasive cancer.Once resected,they must be extensively sampled or,much better,submitted in its entirety for microscopic study to completely rule out associated invasive carcinoma. | Víctor M Castellano-Megías Carolina Ibarrola-de Andrés Guadalupe López-Alonso Francisco Colina-Ruizdelgado | 2014 | World Journal of Gastrointestinal Oncology2014，6，9： | 4 |
| 3 | Chemical and spectroscopic characterization of humic substances from sediment and riparian soil of a highly polluted urban river (Suquía River, Cordoba, Argentina)显示文摘The Suquía River,the largest urban river in C ordoba(Argentina),has been severely polluted for decades.Actions must be taken to restore its environmental quality by managing riparian zones for increased water-self purification.The current study aimed to characterize organic matter(OM)dynamics and humic substances(HS)spectrochemical properties along the lower-middle basin of the Suquía River.Riparian soil(0e20 cm)and sediment(0e10 cm)samples were collected from a reference location(S1)and four polluted sites(S2eS5)during a low-flow period.The contents of soil and sedimentary OM and HS fractions were analyzed by wet oxidation,as well as HS Fourier transform infrared(FT-IR)and ultravioletevisible(UVeVis)spectrochemical properties.The OM and HS fractions from riparian soil were high upstream of C ordoba City(S1 and S2,50.2e50.4 g/kg OM)and within a 50 km downstream location(S5,30.9 g/kg OM)owing to a surplus of fresh plant biomass-carbon(C)inputs.Highly heterogeneous sediment samples did not show any significant differences among sites(P>0.05).The lowest values of the ratio of absorbances at 465 and 665 nm(E4/E6)(1.78)and the Δ log K(0.15)coefficient(a measure of HS maturity degree)were obtained downstream of C ordoba City,for both riparian soil and sediment,indicating that HS were enriched by more condensed aromatic structures within highly degraded portions of the river.All samples exhibited similar IR spectra,implying overlapping recalcitrant-C structures at the functional group level,but with different absorbance intensity.Data from the current study constitute a baseline for understanding the chemical nature of HS from sediment and riparian soil along the Suquía River and can be used as a reference for future studies tracking OM compositional changes over time. | Carolina Merlo Carolina Vázquez Ana Graciela Iriarte Carlos Matías Romero | 2020 | International Journal of Sediment Research2020，35，3： | 3 |
| 4 | ST2可能并非心血管事件、心力衰竭和死亡有用的预测因子显示文摘研究人员假设可溶性ST2(soluble ST2,sST2)水平可识别出心血管疾病(cardiovascular disease,CVD)风险较高的人群,应将其纳入风险预测计算指标。ST2是炎症性细胞因子白细胞介素33的受体。sST2水平增加与急性心肌梗死患者和一般人群的心力衰竭及死亡相关。方法:研究人员测定FINRISK97前瞻性研究人群队列中的8444名男性和女性(25-74岁)的高敏sST2水平,应用Cox比例风险模型评估在15年的随访中,sST2对致命性或非致命性心力衰竭、CVD(冠状动脉性心脏病和脑卒中)、糖尿病和死亡情况的预测能力。研究者获取10年绝对风险识别和重新分类的统计数据, | 赵狄 叶鹏 Hughes MF Appelbaum S Havulinna AS Jagodzinski A Zeller T2 Kee F Blankenberg S Salomaa V | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 5 | Functional outcome of total anorectal reconstruction:incontinence or constipation?显示文摘 | Boselli AS Bernardinis M | 2003 | Acta Bio Medica2003，74，2： | 1 |
| 6 | Identification of novel Mycobacterium boris antigens by dissection of crude protein fractions显示文摘 | Meikle V Alito A Llera AS etal | 2009 | Clin Vaccine Immunol2009，16，9： | 1 |
| 7 | Prediction of deleterious human alleles显示文摘 | Sunyaev S Ramensky V Koch I Lathe W 3rd Kondrashov AS Bork P | | 0，，： | 1 |
| 8 | Probioties and prebioties: role in prevention of nosocomial sepsis in preterm infants 显示文摘 | Nair V Soraisham AS | 2013 | Int J Pediatr2013，2013，87： | 1 |
| 9 | C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy显示文摘 | Olmos P Bastías MJ Vollrath V | | 0，，02： | 1 |
| 10 | Human airway smooth muscle cells express the high affinity receptor for IgE Fc epsilon RI:a critical role of Fc epsilon RI in human airway smooth muscle cell function显示文摘 | Gounni AS Wellemans V Yang J | | 0，，： | 1 |
| 11 | Treatment of antineutrophil cytoplasmic antibody-associated vasculitis:update显示文摘 | Santana AN Woronik V Halpern AS | 2011 | J Bras Pneumol2011，37，6： | 1 |
| 12 | Assessment of thewetting behavior of three different root canal sealers on root canaldentin显示文摘 | Tummala M Chandrasekhar V Rashmi AS | 2012 | J Conserv Dent2012，15，2： | 1 |
| 13 | Glucosamine affects intracel ular signal ing through inhibition of Mitogen-activated protein kinase phosphorylation in human chondrocytes显示文摘 | d'Abusco AS Calamia V Cicione C | | 0，，05： | 1 |
| 14 | The role of direct high-resolution mass spectrometry in foodomics显示文摘 | IBá?EZ C SIMó C GARCíA-CA?AS V | 2015 | Analytical and Bioanalytical Chemistry2015，407，21： | 1 |
| 15 | Infection-derived Enterococcus faecalis strains are enriched in esp,a gene encoding a novel surface protein 显示文摘 | Shankar V Baghdayan AS Huycke MM | 1999 | Infect Immun1999，67，1： | 1 |
| 16 | Demonstrationof an interferon gamma-dependent tumor surveillance sys-tem in immunocompetent mice显示文摘 | Kaplan DH Shankaran V Dighe AS | 1998 | Proc Natl Acad Sci USA1998，95，13： | 1 |
| 17 | Role of inducible nitric oxide synthase in endotoxin induced acute lung injury显示文摘 | Kristor AS Golderg P Laubach V | 1998 | Am J Respir Crit Care Med1998，158，： | 1 |
| 18 | Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats显示文摘 | Muthuraman A Diwan V Jaggi AS Singh N Singh D | 2008 | J Ethnopharmacol2008，120，1： | 1 |
| 19 | Decreasedlevels of GABA in the inferior colliculus of the epilepsy-prone ham- ster (GPG/ValI) 显示文摘 | Fuentes-Santamarta V Alvarado JC Herranz AS | 2008 | Epilepsy Res2008，79，23： | 1 |
| 20 | A comprehensive evidence-based approach to fever of unknown origin显示文摘 | Mourad O Palda V Detsky AS | 2003 | Arch Intern Med2003，163，5： | 1 |
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