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| 1 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 2 | Biochemical approaches for discovering protein-protein interactions 显示文摘 | MIERNYK J A THELEN J J | 2008 | The Plant Journal2008，53，： | 1 |
| 3 | Usingproteomics to study sexual reproduction in angiosperms 显示文摘 | Miernyk J Pret'ov6 A Olmedilla A | 2011 | Sexual Plant Reproduction2011，24，： | 1 |
| 4 | The J-domain proteins oI Arabtdopsts thaltana: an unexpectedly large and diverse family of chaperones 显示文摘 | Miernyk J A | 2001 | Cell Stress Chaperones2001，6，3： | 1 |
| 5 | Seed proteomics 显示文摘 | Miernyk J A Hajduch M | 2011 | J Pro- teomics2011，74，： | 1 |
| 6 | Input-output analysis:The first fifty years显示文摘 | Rose A Miernyk W H | | 0，，04： | 1 |
| 7 | Seed proteomics 显示文摘 | Miernyk J A | 2014 | Methods Mol Biol2014，1072，： | 1 |
| 8 | Input output analysis: the first fifty years 显示文摘 | ROSE A MIERNYK W | 1989 | Economic Systems Research1989，，1： | 1 |
| 9 | Mitochondrial, plastid, and cytosolic isozymes of hexokinase from developing endosperm of Ricinus communis 显示文摘 | Miernyk J A Dennis D T | 1983 | Biochimiea et Biophysica Acta1983，226，： | 1 |
| 10 | Hsc70 can act as a molecular chaperone during the membrane translocation of a plant secretory protein precursor显示文摘 | Miernyk J A Duck N B Shatters J R | 1992 | Plant Cell1992，4，7： | 1 |
| 11 | Using quan- titative proteomics of Arabidopsis roots and leaves to predict metabolic activity 显示文摘 | Mooney B Miernyk J Greenlief C | 2006 | Physiologia Plantarum2006，128，： | 1 |
| 12 | ATPase activity and molecular chaperone function of the stress70 proteins显示文摘 | Miernyk J A Hayman T G | 1996 | Plant Physiol1996，110，2： | 1 |
| 13 | Cloning and characterization of the dihydrolipoamide S - acetyltrans- ferase subunit of the plastid pyruvate dehydrogenase complex ( E2 ) from Arabidopsis 显示文摘 | Mooney B P Miernyk J A Randall D D | 1999 | Plant Physiology1999，120，2： | 1 |
| 14 | Input-Output Analysis: The First Fifty Years显示文摘 | Adam Rose William Miernyk | 1989 | Economic Systems Research1989，，2： | 1 |
| 15 | Partial purification and characterization of the maize mitochondrial pyruvate dehydrogenase complex显示文摘 | Thelen J J Miernyk J A Randall D D | 1998 | Plant Physiol1998，116，： | 1 |
| 16 | The 70-kilodation heat shock cognate can act as a molecular chaperone during the membrane translocation of a plant secretory protein precusor显示文摘 | Miernyk J A Duck N B Shatters R G Jr | 1992 | Plant Cell1992，4，： | 1 |
| 17 | Seed proteomics显示文摘 | MIERNYK J A HAJDUCH M | 2011 | J Proteomics2011，74，： | 1 |
| 18 | Performance of a rapid antigen test (Binax NOWRSV) for diagnosis of respiratory syneytial virus compared with real time polymerase chain reaction in a pediatric population 显示文摘 | Miernyk K Bulkow L De Byle C | 2011 | J Clin Virol2011，50，3： | 1 |
| 19 | Molecular analysis of two pyruvate dehydrogenase kinases from maize显示文摘 | Thelen J J Muszynski M G Miernyk J A | 1998 | The Journal of Biological Chemistry1998，273，26： | 1 |
| 20 | The 70 kDa stress-related proteins as molecular chaperones显示文摘 | MIERNYK J A | 1997 | Trends in Plant Science1997，2，5： | 1 |
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