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| 1 | Prognostic significance of tumor immune microenvironment and immunotherapy:Novel insights and future perspectives in gastric cancer显示文摘Despite a decrease in gastric cancer incidence, the development of novel biologic agents and combined therapeutic strategies, the prognosis of gastric cancer remains poor. Recently, the introduction of modern immunotherapy, especially using immune checkpoint inhibitors, led to an improved prognosis in many cancers. The use of immunotherapy was also associated with manageable adverse event profiles and promising results in the treatment of patients with gastric cancer, especially in heavily pretreated patients. These data have led to an accelerated approval of some checkpoint inhibitors in this setting. Understanding the complex relationship between the host immune microenvironment and tumor and the immune escape phenomenon leading to cancer occurrence and progression will subsequently lead to the identification of prognostic immune markers. Furthermore, this understanding will result in the discovery of both new mechanisms for blocking tumor immunosuppressive signals and pathways to stimulate the local immune response by targeting and modulating different subsets of immune cells. Due to the molecular heterogeneity of gastric cancers associated with differentclinico-biologic parameters, immune markers expression and prognosis, novel immunotherapy algorithms should be personalized and addressed to selected subsets of gastric tumors, which have been proven to elicit the best clinical responses. Future perspectives in the treatment of gastric cancer include tailored dual immunotherapies or a combination of immunotherapy with other targeted agents with synergistic antitumor effects. | Daniela Cornelia Lazǎr Mihaela Flavia Avram Ioan Romosan Mǎrioara Cornianu Sorina Tǎan Adrian Goldis | 2018 | World Journal of Gastroenterology2018，24，32： | 24 |
| 2 | Photoeatalytic degradation of dichlorvos in aqueous TiO2 suspensions显示文摘 | ONCESCU T MIHAELA I OANCEA P | 2010 | Environmental Science and Pollution Research2010，17，5： | 1 |
| 3 | Investigation of electrochemical reversibility and redox-active polypyrrole film formation of amide ferrocene-pyrrole derivatives 显示文摘 | Saint A E Mihaela U Visan T | 1997 | Electrochim Acta1997，42，： | 1 |
| 4 | A power quality index based on equipment sensitivity,cost and network vulnerability显示文摘 | Lee G J Mihaela M A Gerald T H | 2004 | IEEE Trans on Power Delivery2004，19，3： | 1 |
| 5 | Energy EfficientTarget Coverage in Wireless Sensor Networks 显示文摘 | Mihaela Cardei Thai M T Yingshu Li | 2005 | IEEE INFO-COM2005，，： | 1 |
| 6 | Photocatalytic degradationofdichiorvos in aqueous TiO2 suspensions 显示文摘 | Oncescu T Mihaela I Stefan Oancea P | | Environmental Science and Pollution Research0，17，5： | 1 |
| 7 | Particular evolution in a 72-year-old diabetic patient with acute coronary syndrome显示文摘 | Gabriela S Gheorghe Ana Clobanu Ioan T Nanea Andreea S Serban Mihaela R Mititelu | 2018 | Journal of Geriatric Cardiology2018，15，7： | 1 |
| 8 | Pulmonary endothelial cell activation during experimental acute kidney injury显示文摘 | Carolyn M Heitham T Mihaela L | | 0，，02： | 1 |
| 9 | Selective Cu2+ ad- sorption and recovery from contaminated water using me- soporous hybrid silica bio-adsorbents显示文摘 | Mihaela M Nicoleta C Ion T | 2011 | Microporous and Mesoporous Materials2011，146，： | 1 |
| 10 | Liposomes as possible carriers for lactoferrin in the local treatment of inflammatory Diseases显示文摘 | Mihaela T Cristina G Diane M | 2001 | Exp Bio Med2001，226，6： | 1 |
| 11 | WA-PLS diatom-based pH, TP and DOC inference models from 42 lakes in the Abitibi clay belt (Quebec, Canada) 显示文摘 | Mihaela Enache Yves T Prairie | 2002 | Journal of paleolimnology2002，27，： | 1 |
| 12 | Mesoporous silica functionalized with 1-furoyl thiourea urea for Hg(Ⅱ) adsorption from aqueous media显示文摘 | MIHAELA M AURORA R NICOLETA C ION T VASILE H | 2010 | Journal of Hazardous Materials2010，182，13： | 1 |
| 13 | Quantitative fluorescence in situ hybridization and its ability to predict bladder cancer recurrence and progression to muscle-invasive bladder cancer 显示文摘 | Benjamin R K Mihaela T Terry A E | 2009 | Journal of Molecular Diagnostics2009，11，2： | 1 |
| 14 | Extrapancreatic necrosis volume:A new tool in acute pancreatitis severity assessment?显示文摘BACKGROUND Many scores have been suggested to assess the severity of acute pancreatitis upon onset.The extrapancreatic necrosis volume is a novel,promising score that appears to be superior to other scores investigated so far.AIM To evaluate the discriminatory power of extrapancreatic necrosis volume to identify severe cases of acute pancreatitis.METHODS A total of 123 patients diagnosed with acute pancreatitis at Institute of Gastroenterology and Hepatology,St Spiridon Hospital between January 1,2017 and December 31,2019 were analyzed retrospectively.Pancreatitis was classified according to the revised Atlanta classification(rAC)as mild,moderate,or severe.Severity was also evaluated by computed tomography and classified according to the computed tomography severity index(CTSI)and the modified CTSI(mCTSI).The results were compared with the extrapancreatic volume necrosis to establish the sensitivity and specificity of each method.RESULTS The CTSI and mCTSI imaging scores and the extrapancreatic necrosis volume were highly correlated with the severity of pancreatitis estimated by the rAC(r=0.926,P<0.001 and r=0.950,P<0.001;r=0.784,P<0.001,respectively).The correlation of C-reactive protein with severity was positive but not as strong,and was not significant(r=0.133,P=0.154).The best predictor for the assessment of severe pancreatitis was the extrapancreatic necrosis volume[area under the curve(AUC)=0.993;95%confidence interval(CI):0.981-1.005],with a 99.5%sensitivity and 99.0%specificity at a cutoff value of 167 mL,followed by the mCTSI 2007 score(AUC=0.972;95%CI:0.946-0.999),with a 98.0%sensitivity and 96.5%specificity,and the CTSI 1990 score(AUC=0.969;95%CI:0.941-0.998),with a 97.0%sensitivity and 95.0%specificity.CONCLUSION Radiological severity scores correlate strongly and positively with disease activity.Extrapancreatic necrosis volume shows the best diagnostic accuracy for severe cases. | Bogdan Cucuteanu DragoşNegru Otilia Gavrilescu Iolanda Valentina Popa Mariana Floria Cătălina Mihai Cristina Cijevschi Prelipcean Mihaela Dranga | 2021 | World Journal of Clinical Cases2021，9，31： | 0 |
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