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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | Localization and quan- tification of circular DNA in yeast显示文摘 | Clark-Walker G D Miklos G L | 1974 | European Jour- nal of Biochemistry1974，41，2： | 1 |
| 3 | The role of the genome project in determining gene function:insights from model organisms显示文摘 | Rubin G M | 1996 | Cell1996，86，4： | 1 |
| 4 | The role of the genome project in determining gene function:insights from model organisms显示文摘 | MIKLOS G L RUBIN G M | 1996 | Cell1996，86，4： | 1 |
| 5 | Protein functions and biological contexts 显示文摘 | Miklos G Maleszka R | 2001 | Proteomics2001，1，2： | 1 |
| 6 | Protein functions and biological contexts显示文摘 | Gabor Miklos G L Maleszka R | 2001 | Proteomics2001，1，： | 1 |
| 7 | Protein nuclear magnetic resonance underphysiological conditions显示文摘 | PIELAK G J LI C MIKLOS A C | 2009 | Biochemistry2009，48，2： | 1 |
| 8 | Photoacoustic detection of ozone using a quantum cascade laser显示文摘 | DA Silva M G Vargas H Miklos A | 2004 | Lasers and Optics2004，78，6： | 1 |
| 9 | Vasarhelyi,Restoring auditor credibility tertiary monitoring and logging of continuous assurance systems显示文摘 | MICHAEL G ALLES ALEXANDER KOGAN MIKLOS A | 2004 | Accounting Information Systems2004，5，： | 1 |
| 10 | TCP1 complex is a molecular chaperone in tubulin biogenesis 显示文摘 | YAFFE M B FARR G W MIKLOS D | 1992 | Nature1992，358，6383： | 1 |
| 11 | The role of the genome project in determining gene function insights from model organisms显示文摘 | Miklos G L G Rubin G M | 1996 | Cell1996，86，4： | 1 |
| 12 | Design aspects of network assisted device-to-device communications显示文摘 | FODOR G DAHLMAN E MILDH G PARKVALL S REIDER N MIKLOS G TURANYI Z | 2012 | IEEE Communications Magazine2012，50，12： | 1 |
| 13 | Identification of the sex pheromone composition of the click beetle Agriotes brevis Candeze (Coleoptera: Elateridae)显示文摘 | Miklo s To th Lorenzo Furlan Venyamin G Yatsynin | 2002 | Journal Chemical Ecology2002，28，8： | 1 |
| 14 | Identification of pheromones and optimization of bait composition for click beetle pests (Coleoptera: Elateridae) in Central and Western Europe显示文摘 | Miklos To th Lorenzo Furlan Venyamin G Yatsynin | 2003 | Pest Management Science2003，59，： | 1 |
| 15 | Chro- maticity, brightness and aging of silica spray coated zinc sulfide silver phosphor particles 显示文摘 | VILLALOBOS G SANGHERA J MIKLOS R | 2005 | Journal of Materials Science2005，40，23： | 1 |
| 16 | Single-center retrospective study of the technique, safety, and 12-month efficacy of the MiniArc^TM single-incision sling: a new minimally invasive procedure for treatment of female SUI显示文摘 | MOORE R D MITCHELL G K MIKLOS J R | 2009 | Surg Technol Int2009，18，： | 1 |
| 17 | Protein nuclear magnetic resonance under physiological conditions显示文摘 | Pielak G J Li C Miklos A C | 2009 | Bi ochemistry2009，48，2： | 1 |
| 18 | The role of the genome project in determining gene function:insights from model organisms显示文摘 | Miklos G L Rubin G M | 1996 | Cell1996，86，4： | 1 |
| 19 | The human cancer genome project:one more misstep in the war on cancer显示文摘 | Gabor Miklos G L | 2005 | Nat Biotechnol2005，23，5： | 1 |
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