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| 1 | 盐酸美金刚在中国治疗阿尔茨海默病的药物经济学模型显示文摘目的探讨从中度阿尔茨海默病(AD)开始盐酸美金刚治疗与仅从重度AD开始盐酸美金刚治疗在中国的临床和经济效益。方法运用马尔可夫模型,通过定义患者的不同健康状况,模拟了中度AD患者在5年中的疾病进展。研究对两组患者进行了比较:1从中度AD开始接受美金刚治疗(进入模型的时期)并持续至病情发展到重度AD的患者;2仅从重度AD开始接受美金刚治疗的患者。结果 5年后,从中度AD开始美金刚治疗的患者中,较少的患者发展至重度AD(49%),依赖他人(59%)或有激越行为(47%);相比对于从重度AD开始治疗的患者分别为58%、67%和55%。从中度AD开始美金刚治疗的全国总治疗费用(670亿人民币)低于从重度AD开始的费用(730亿人民币)。结论在中国,从中度AD开始使用美金刚治疗可以节省大量成本。 | 胡善联 于欣 Emilie Clay Mondher Toumi Dominique Milea | 2016 | 中国药物经济学2016，0，9： | 2 |
| 2 | Clinical management and associated costs for moderate and severe Alzheimer’s disease in urban China: a Delphi panel study显示文摘Background:Healthcare resource utilisation for Alzheimer’s disease(AD)in China is not well understood.This Delphi panel study aimed to describe the clinical management pathways for moderate and severe AD patients in urban China and to define the amount and cost of healthcare resources used.Methods:A panel of 11 experts was recruited from urban China to participate in two rounds of preparatory interviews.In the first round,9 physicians specialised in dementia gave a qualitative description of the clinical management of AD patients.In the second round,2 hospital administrators were asked about the cost of AD management and care.Results from the interviews were discussed by the experts in a Delphi panel meeting,where consensus was reached on quantitative aspects of AD management,including the rate of healthcare resource utilisation,the respective unit costs and caregiving time.Results:Interviewees reported that mild AD is under-recognised in China;most patients are diagnosed with moderate to severe AD.Loss of independence and agitation/aggression are the main drivers for healthcare resource utilisation and contribute to a heavier caregiver burden.It was estimated that 70%moderate AD patients are independent/non-aggressive at the time of diagnosis,15%are independent/aggressive,10%are dependent/non-aggressive,and 5%are dependent/aggressive.Dependent/aggressive AD patients are more likely to be hospitalised(70–90%)than accepted in a nursing home(0–20%),while the opposite is true for dependent/non-aggressive patients(5–35%for hospitalisation vs.80%for nursing home).Independent AD patients require 1–3 hours/day of caregiver time,while dependent patients can require up to 12–15 hours/day.Experts agreed that AD complicates the management of age-related comorbidities,found in 70–80%of all AD patients,increasing the frequency and cost of hospitalisation.Conclusions:The Delphi panel approach was an efficient method of gathering data about the amount of healthcare resources used and associated costs for moderate and severe AD patients in urban China.The results of this study provide a useful source of information for decision makers to improve future healthcare policies and resource planning,as well as to perform economic evaluations of AD therapies. | Xin Yu Shengdi Chen Xiaochun Chen Jianjun Jia Chunhou Li Cong Liu Mondher Toumi Dominique Milea | 2015 | Translational Neurodegeneration2015，4，1： | 2 |
| 3 | Indocyanine green angiography in choroidal tuberculomas显示文摘 | Milea D Fardeu C lumbros L | 1999 | Br J ophthalmal1999，83，6： | 1 |
| 4 | Improved locus-specific database for OPA1 mutations allows inclusion of advanced clinical data显示文摘 | Ferré M Caignard A Milea D | 2015 | Hum Mutat2015，36，1： | 1 |
| 5 | Pupillary responses to high-irradiance blue light correlate with glaucoma severity显示文摘 | RUKMINI AV MILEA D BASKARAN M HOW AC PERERA SA AUNG T | 2015 | Ophthalmol- ogy2015，122，9： | 1 |
| 6 | Cavernous sinus dural fistulae treated by transvenous approach through the facial vein:report of seven cases and review of the literature显示文摘 | Biondi A Milea D Cognard C | 2003 | Am J Neuroradiol2003，24，： | 1 |
| 7 | Axonal loss occurs early in dom-inant optic atrophy 显示文摘 | Milea D Sander B Weqener M | 2010 | Acta Ophthalmol2010，88，3： | 1 |
| 8 | OPA1 -associateddisorders : Phenotypes and pathophysiology 显示文摘 | Amati-Bonneau P Milea D Bonneau D | 2009 | Int J Biochem CellBiol2009，41，10： | 1 |
| 9 | Molecular screening of 980cases of suspected of hereditary optic neuropathy with a report on 77novel OPA1 mutations 显示文摘 | Ferr6 M Bonneau D Milea D | 2009 | Hum Mutat2009，30，7： | 1 |
| 10 | Vertical nystagmus:clinical facts and hypotheses显示文摘 | Pierrot-Deseilligny C Milea D | 2005 | Brain2005，128，： | 1 |
| 11 | Acute retrobulbar optic neuropathy due to rupture of anterior communication artery aneurysm显示文摘 | Claes C Milea D Bodaghi B | 2006 | Acta Ophthalmol Scand2006，84，： | 1 |
| 12 | Formation and Stability of Phytate Complexes in Solution显示文摘 | FRANCESCO Crea CONCETTA De Stefano DEMETRIO Milea | 2008 | Coordination Chemistry2008，252，： | 1 |
| 13 | Retinal lesions in pseudoxanthoma elasticum:51 patients显示文摘 | Tre1ohan A Martin L Milea D | 2011 | J Fr Ophtalmol2011，34，1： | 1 |
| 14 | Cerebral migration of intraocular silicone oil: an MRI study显示文摘 | Kiilgaard JF Milea D Lcgager V | 2011 | Acta Ophthalmol2011，89，6： | 1 |
| 15 | Cavernous sinus dural fistulae treated by transvenous approach through the facial vein:report of seven eases and review of the literature 显示文摘 | Biondi A Milea D Cognard C | 2003 | AJNR2003，24，： | 1 |
| 16 | Manifestations atypiques de la myasthénie oculaire显示文摘 | D. Milea P. Laforet B. Eymard | 2005 | Revue Neurologique2005，，5： | 1 |
| 17 | Disease activity in idiopathic in- tracranial hypertension : a 3-month follow-up study 显示文摘 | Skau M Sander B Milea D | 2011 | J Neurol2011，258，2： | 1 |
| 18 | Atypical ocular myasthenia gravis显示文摘 | Milea D Laforet P EymardB | 2005 | Rev Neurol (Paris)2005，161，5： | 1 |
| 19 | Sensorineural hearing loss in OPA1-linked disorders显示文摘 | Leruez S Milea D Defoort-Dhellemmes S | 2013 | Brain2013，136，7： | 1 |
| 20 | Atypical ocular myasthe-nia gravis 显示文摘 | Milea D Laforet P Eymard B | 2005 | Rev Neurol ( Paris)2005，161，5： | 1 |
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