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53篇 您的检索式:作者名="Mills JC"
    题名 作者 年代 出处 被引量
1miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 2018神经损伤与功能重建2018,13,12:3
2Risk factors of postoperative myocardial infarction after colorectal surgeries显示文摘Moghadamyeghaneh Z Mills SD Carmichael JC 2015Am Surg2015,81,4:1
3Sarcomatoid carcinomas (carcinosarcomas) of the gastrointestinal tract:a review显示文摘Iezzoni JC Mills SE 1993Semin Diagn Pathol1993,10,2:1
4Accuracy of CT guid- ance of lumbar facet joint bloek显示文摘Weininger M Mills JC Rumboldt Z et aI 2013Am J Roentgenol2013,200,67:1
5Suicidal ingestion of barium- sulfide - containing shaving powder 显示文摘Downs JC Milling D Nichols CA 1995Am J Forensic Med Pathol1995,16,1:1
6Myosin light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1 显示文摘Mills JC Stone NL Erhardt J 2001J Biol Chem2001,276,13:1
7Dexamethasone and tumor necrosis factor-alpha act together to induce the cellular inhibitor of apoptosis-2 gene and prevent apoptosis in a variety of cell types显示文摘 Huber RM Hanson RL Collier PM Haws TF Mills JK Burn TC Allegretto EA 2002Endocrinology2002,143,10:1
8Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury 显示文摘Pull SL Doherty JM Mills JC 2005Proc Natl Acad Sci USA2005,102,1:1
9Tetranucleotide repeat polymorphism at the human alpha fibrinogen locus (FGA)显示文摘Mills KA Even D Murray JC 1992Hum Mol Genet1992,1,9:1
10Tizanidine:a novel effective agent forthe treatment of chronic headaches显示文摘Krusz JC Belanger J Mills C 2000Headache2000,11,2:1
11Sarcomatoid carcinomas (carcino- sarcomas) of the gastrointestinal tract: a review显示文摘Iezzoni JC Mills SE 1993Semin Diagn Pathol1993,10,2:1
12Sarcomatoid carcinomas (carcinosarcomas) of the gastrointestinal tract:a review显示文摘Iezzoni JC Mills SE 0,,:1
13An animal model for studying mechanisms in human temporomandibular joint disc derangement显示文摘Mills DK Deniel JC Herzog S 1994J Oral Maxillofac Surg1994,52,12:1
14Molecular properties of adult mouse gastric and intestinal epithelial progenitors in their niches显示文摘Giannakis M Stappenbeck TS Mills JC 2006J Biol Chem2006,281,11:1
15GATA2 functions at multiple steps in hemangioblast development and differentiation显示文摘Lugus JJ Chung YS Mills JC 2007Development2007,134,2:1
16CT measured normative cartilage growth in children requiring costochondral grafting显示文摘Andreoli SM Mills JC Kilpatrick LA 2013Otolaryngol Head Neck Surg2013,149,6:1
17Physico-chemical characterisation and transfection efficiency of lipid-based gene delivery complexes显示文摘Birchall JC Kellaway IW Mills SN 1999Int JPharm1999,183,2:1
18An animal model for studying mechanisms in human tempornmandibular joint disc derangement 显示文摘Mills DK Daniel JC Herzog S 1994J Oral Maxillofac Surg1994,52,12:1
19Utilization of laparoscopyin colorectal surgery for cancer at academic medical centers: doessite of surgery affect rate of laparoscopy 显示文摘Carmichael JC Masoomi H Mills S 2011Am Surg2011,77,10:1
20A new approach for filtering noise from high-density oligonucleotide microarray datasets显示文摘Mills JC Gordon JI 2001Nucleic Acids Res2001,29,15:1
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