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| 1 | Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population显示文摘AIM: To investigate features of Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) among a Mexican population.METHODS: Cases of primary gastric adenocarcinoma were retrieved from the files of the Departments of anatomic site of the gastric neoplasia was identified, and carcinomas were histologically classified as intestinal and diffuse types and subclassified as proposed by the Japanese Research Society for Gastric Cancer. EBV-encoded small non-polyadenylated RNA-1 (EBER-1)in situ hybridization was conducted to determine the presence of EBV in neoplastic cells.RESULTS: We studied 330 consecutive, non-selected,primary gastric carcinomas. Among these, there were173 male and 157 female patients (male/female ratio1.1/1). EBER-1 was detected in 24 (7.3%) cases (male/female ratio: 1.2/1). The mean age for the entire group was 58.1 years (range: 20-88 years), whereas the mean age for patients harboring EBER-1-positive gastric carcinomas was 65.3 years (range: 50-84 years). Age and histological type showed statistically significant differences, when EBER-1-positive and -negative gastric carcinomas were compared. EBER-1 was detected in hyperplastic- and dysplastic-gastric mucosa surrounding two EBER-1-negative carcinomas, respectively.CONCLUSION: Among Latin-American countries, Mexico has the lowest frequency of EBVaGC. Indeed, the Mexican population >50 years of age was selectively affected. Ethnic variations are responsible for the epidemiologic behavior of EBVaGC among the worldwide population. | Roberto Herrera-Goepfert Suminori Akiba Chihaya Koriyama Shan Ding Edgardo Reyes Tetsuhiko Itoh Yoshie Minakami Yoshito Eizuru | 2005 | World Journal of Gastroenterology2005，11，39： | 14 |
| 2 | E-cadherin and beta-catenin expression in Epstein-Barr virus-associated gastric carcinoma and their prognostic significance显示文摘AIM: To examine the role of E-cadherin and beta- catenin in carcinogenesis and to assess their prognostic implication in Epstein-Barr virus-associated gastric carcinomas (EBV-GCs). METHODS: We compared the frequency of E-cadherin and beta-catenin expression in 59 EBV-GCs and 120 non-EBV-GCs, and examined the association between patients' prognosis and the expressions of these proteins. RESULTS: Neither the cellular-membranous nor the cytoplasmic E-cadherin expression showed any difference between EBV-GCs and non-EBV-GCs. On the other hand, loss of membranous expression of beta- catenin occurred more frequently in non-EBV-GCs than EBV-GCs [odds ratio = 0.41; 95% confidence interval (CI), 0.19-0.90]. Furthermore, the nuclear and/or cytoplosmic expression of beta-catenin was seen more frequentlyin EBV-GCs than non-EBV-GCs (odds ratio = 2.23; 95% CI, 0.97-5.09), and was observed in a larger proportion of carcinoma cells of EBV-GCs than non-EBV-GCs (P = 0.024). Survival analysis for non-EBV-GC revealed that lymph node metastasis was significantly associated with poor prognosis (P < 0.001). Among EBV- GCs, the depth of invasion (P = 0.005), lymph node metastasis (P = 0.004) and an intestinal type by Lauren classification (hazard ratio = 9.47; 95% CI, 2.67-33.6) were significantly associated with poor prognosis. On the other hand, nuclear and/or cytoplasmic expression of beta-catenin was associated with a better prognosis in patients with EBV-GC (hazard ratio = 0.32; 95% CI, 0.11-0.93). CONCLUSION: We observed more frequent preservation of beta-catenin in cell membrane and accumulation in nuclei and/or cytoplasm in EBV-GCs than in non-EBV- GCs. Factors involved in the prognosis of EBV-GCs and non-EBV-GCs are different in the two conditions. | Chihaya Koriyama Suminori Akiba Tetsuhiko Itoh Kazunobu Sueyoshi Yoshie Minakami Alejandro Corvalan Suguru Yonezawa Yoshito Eizuru | 2007 | World Journal of Gastroenterology2007，13，29： | 6 |
| 3 | Preeclampsia: a microvesicular fat disease of the liver显示文摘 | Minakami H Oka N Sato J | 1988 | Am J Obstet Gynecol1988，159，： | 1 |
| 4 | Uterine leiomyoma in pregnancy:its influence on obstetric performance显示文摘 | Koike T Minakami H Kosuge S | 1999 | J Obstet Gynaecol Res1999，25，： | 1 |
| 5 | Reestimating date of delivery in multifetal pregnancies显示文摘 | Minakami H Sato I | 1996 | JAMA1996，275，18： | 1 |
| 6 | Serum procalcitonin concen- tration in patients with Kawasaki disease 显示文摘 | Okada Y Minakami H Tomomasa T | 2004 | J Infect2004，48，2： | 1 |
| 7 | The problem of relating fetal outcome with breech presentation to mode of delivery显示文摘 | Minakami H Sasaki M | 1996 | Arch Gynecol Obstet1996，258，3： | 1 |
| 8 | Serum procalcitonin concentration in patients with Kawasaki disense显示文摘 | Okada Y Minakami H Tomomasa T | 2004 | J Infect2004，48，2： | 1 |
| 9 | Characterization of human neutrophil leukotriene B4 ω-hydroxylase as a system involving a unique cytochrome P-450 and NADPH-cytochrome P-450 reductase显示文摘 | Sumimoto H Takeshige K Minakami S | 1988 | J Biochem1988，172，2： | 1 |
| 10 | Outbreak of gastroenteritis caused by echovirus type 6 in an orphanage in Japan显示文摘 | Abe O Kimura H Minakami H | 2000 | J Infect2000，41，3： | 1 |
| 11 | Studies on the respiratory chain-linked dihydrodiphosphopyridine nucleotide dehydrogenase 显示文摘 | MINAKAMI S RINGLER R L SINGER T P | 1962 | Biol Chem1962，237，2： | 1 |
| 12 | Effeet of labor on maternal dehydration, starvation, coagulation, and fibrinolysis 显示文摘 | Watanabe T Minakami H Sakata Y | 2001 | JPerinat Med2001，29，： | 1 |
| 13 | Serum procalcitonin concentration in patients with Kawasaki disease显示文摘 | Okada Y Minakami H Tomomasa T | 2004 | J Infect2004，48，2： | 1 |
| 14 | Chemotactic activity for polymorphonuclear leukocytes: meconium versus meconium-stained amniotic fluid 显示文摘 | Yamada T Matsubara S Minakami H | 2000 | AM J Reprod Immunol2000，44，5： | 1 |
| 15 | Comparison of the longterm effects of oral estriol with the effects of conjugated estrogen on serum lipid profile in early menopausal women显示文摘 | Itoi H Minakami H Iwasaki R | 2000 | Maturitas2000，36，： | 1 |
| 16 | Differentiation of acute fatty liver of pregnancy from syndrome of hemolysis, elevated liver enzymes and low platelet counts 显示文摘 | Minakami H Morikawa M Yamada T | 2014 | J Obstet Gynaecol Res2014，40，： | 1 |
| 17 | Uterine leio- myoma in pregnancy: its influence on obstetric performan -ce 显示文摘 | KOIKE T MINAKAMI H KOSUGE S | 1999 | The Journal of Obstetrics and Gynaecology Research1999，25，5： | 1 |
| 18 | Serum Procalcitonin Concectration in Patients with Kawasaki Disease显示文摘 | Okada Y Minakami H Tomomasa T | 2004 | J Infect2004，48，2： | 1 |
| 19 | Serum prcalcitonin concentration in patients with Kawasaki disease 显示文摘 | Okada Y Minakami H Tomomasa T | 2004 | J Infect2004，48，2： | 1 |
| 20 | Serum procalcitonin concentration in patients with Kawasaki disease显示文摘 | Okada Y Minakami H Tomomasa T | | 0，，02： | 1 |
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