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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | p53, Bcl-2 and C-Myc ex- pressions in colorectal carcinoma associated with schistosomiasis in Egypt显示文摘 | Zalata KR Nasif WA Ming SC | 2005 | Cell Oncol2005，27，4： | 1 |
| 3 | Gastric dysplasia:Significance and pathologic criteria显示文摘 | Ming SC Bajtai A Correa D etal | 1984 | Cancer1984，54，： | 1 |
| 4 | Gastric carcinoma:a pathobiological classification显示文摘 | Ming SC | 1977 | Cancer1977，39，6： | 1 |
| 5 | Dynamic Analysis for Structures Isolated with Dampers显示文摘- In this paper, mathematical models and dynamic analyses for both SDOF and MDOF structures isolated with dampers are established and performed, and a comprehensive computation method is provided. The shock absorbing effect is illustrated through an example of a two DOF damper-isolated system excited by sinusoidal waves and actual ground acceleration input recorded in earthquakes. It is shown that most of the responses of the structure with dampers reduce greatly near the resonant zone, but acceleration is enlarged in the lower or higher frequency zone; among various parameters, the influence of frictional coefficient n is the most significant, that of damping ratio of the dampers , is the second, and that of stiffness coefficient of the dampers k, is the slightest. | Gu Peiying and Gao Ming M. Sc, Engineer, Material and Structure Department, Nanjing Hydraulic Research Institute, Nanjing 210024 Professor, Material and Structure Department, Nanjing Hydraulic Research Institute, Nanjing 210024 | 1996 | China Ocean Engineering1996，11，3： | 1 |
| 6 | p53, Bcl-2 and C-Myc expressions in colorectal carcinoma associated with schistosomiasis in Egypt显示文摘 | Zalata KR Nasif WA Ming SC | 2005 | Cell Oncol2005，27，4： | 1 |
| 7 | Cellular and molecular pathology of gastric carcinoma and precursor lesions:A critical review显示文摘 | | 1998 | Gastric Cancer1998，1，： | 1 |
| 8 | Cellular and molecular pathology of gastric carcinoma and precursor lesions: a critical review 显示文摘 | Ming SC | 1998 | Gastric Cancer1998，1，1： | 1 |
| 9 | Gastric carcinoma: a pathobiological classification 显示文摘 | Ming SC | 1977 | Cancer1977，117，39： | 1 |
| 10 | Hemorrhagic necrosis of the gastrointestinal tract and its relation to cardiovascular status 显示文摘 | Ming SC | 1965 | Circulation1965，32，3： | 1 |
| 11 | Gastric carcinoma:a pathological classification显示文摘 | Ming SC | | 0，，06： | 1 |
| 12 | p53, Bcl-2 and C- MYC expressions in colorectal carcinoma associated with schistosomiasis in Egypt 显示文摘 | Zalata KR Nasif WA Ming SC | 2005 | Cell Oncol2005，27，4： | 1 |
| 13 | Mechanisms of antiplatelet and antithrombotic activity of midazolam in vitro and in vivo studies 显示文摘 | George H Ming YS Duen SC | 2004 | Euro J Pharma2004，487，13： | 1 |
| 14 | Gastric dysplasia significance and pathologic criteria 显示文摘 | Ming SC Bajjtai A Correa P | 1984 | Cancer1984，54，： | 1 |
| 15 | Detailed alignment of Saccharum and Sorghum chromosomes;comparative organization of closely related diploid and polyploid genomes 显示文摘 | Ming R Liu SC Lin YR | 1998 | Genetics1998，，150： | 1 |
| 16 | Gastric dysplasia significanc e and pathologic criteria显示文摘 | Ming SC Bajtai A Correa P | 1984 | Cancer1984，54，： | 1 |
| 17 | Intestinal metaplasia and Histogenesis of Carcinoma in Human stomach: light and Electron micrcecopic study显示文摘 | Ming SC Goldman H Freiman DG | 1967 | Cancer1967，20，： | 1 |
| 18 | Gastric carcinoma:a pathological classification显示文摘 | Ming SC | 1977 | Cancer1977，39，： | 1 |
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