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您的检索式：作者名="Mingbao Lin"
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| 1 | Ginsenoside Rg1 protects against transient focal cerebral ischemic injury and suppresses its systemic metabolic changes in cerabral injury rats显示文摘Ginsenoside Rg1(GR),a major bioactive compound of traditional Chinese medicine,such as Panax ginseng or Radix Notoginseng,has been shown to exert neuroprotective effects against ischemic stroke.However,pharmacokinetic studies have suggested that GR could not be efficiently transported through the blood–brain barrier.The mechanism by which GR attenuates cerebral ischemic injury in vivo remains largely unknown.Therefore,this study explored potential neuro-protective effects of GR through its systemic metabolic regulating mechanism by using mass spectrometry–based metabolomic profiling.Rats with middle cerebral artery occlusion(MCAO) were treated with GR intravenously.Their metabolic profiles in serum were measured by gas chromatography coupled with mass spectrometry on 1 and 3 days after MCAO.GR exhibited a potent neuro-protective effect by significantly decreasing the neurological scores and infarct volume in the MCAO rats.Moreover,18 differential metabolites were tentatively identified,all of which appeared to correlate well with these disease indices.Our findings suggested that GR carries a therapeutic potential in stroke possibly through a feed-back mechanism by regulating systematic metabolic mediation. | Mingbao Lin Wei Sun Wan Gong Yasi Ding Yuanyan Zhuang Qi Hou | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 7 |
| 2 | Microbiological quality of roof tank water in an urban village in southeastern China显示文摘Urban villages are unique residential neighborhoods in urban areas in China. Roof tanks are their main form of water supply, and water quality deterioration might occur in this system because of poor hygienic conditions and maintenance. In this study, water samples were seasonally collected from an urban village to investigate the influence of roof tanks as an additional water storage device on the variation in the microbial community structure and pathogenic gene markers. Water stagnation in the roof tank induced significant decreases in chlorine(p < 0.05), residual chlorine was as low as 0.02 mg/L in spring. Propidium monoazide(PMA)-qPCR revealed a one-magnitude higher level of total viable bacterial concentration in roof tank water samples(2.14 ± 1.81 × 105gene copies/mL) than that in input water samples(3.57 ± 2.90 × 104gene copies/mL, p < 0.05), especially in spring and summer. In addition,pathogenic fungi, Mycobacterium spp., and Legionella spp. were frequently detected in the roof tanks. Terminal users might be exposed to higher microbial risk induced by high abundance of Legionella gene marker. Spearman’s rank correlation and redundancy analysis showed that residual chlorine was the driving force that promoted bacterial colonization and shaped the microbial community. It is worth noted that the sediment in the pipe will be agitated when the water supply is restored after the water outages, which can trigger an increase in turbidity and bacterial biomass. Overall, the findings provide practical suggestions for controlling microbiological health risks in roof tanks in urban villages. | Dong Hu Jie Zeng Jing Chen Wenfang Lin Xinyan Xiao Mingbao Feng Xin Yu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 3 | Effect of the ultraviolet/chlorine process on microbial community structure,typical pathogens,and antibiotic resistance genes in reclaimed water显示文摘Urban wastewater contains a wide range of pathogens and antibiotic resistance genes(ARGs),which are a serious concern if reusing treated wastewater.However,few studies have explored the microbial communities in reclaimed water using ultraviolet(UV)/chlorine treatment and assessed the changes of the resistome.This study investigated the occurrence of typical pathogens,ARGs,and bacterial communities in UV/chlorine-treated reclaimed water samples.The numbers of culturable and viable but non-culturable pathogens were effectively reduced to 0 CFU/mL within 1–10 and 10–30 min after UV/chlorine treatment,respectively.Meanwhile,the physicochemical indices of water quality were not affected.UV/chlorine treatment could significantly change the bacterial community structure of reclaimed water,showing a decrease in bacterial abundance and diversity.Chlorine-resistant Acinetobacter and Mycobacterium were the dominant bacterial genera(>50%)after UV/chlorine treatment.Moreover,the number of ARGs and mobile genetic elements(MGEs)decreased with an increase in UV/chlorine exposure.However,eight ARGs and three MGEs were consistently detected in more than three seasons,making these major concerns because of their potential role in the persistence and dissemination of antibiotic resistance.Overall,the results of this study suggest that UV/chlorine treatment can potentially improve the microbiological safety of reclaimed water.And more attention should be paid to the pathogens that are both chlorine-resistant and carry MGEs because of their potential for resistance transmission. | Chengsong Ye Yuming Chen Lin Feng Kun Wan Jianguo Li Mingbao Feng Xin Yu | 2022 | Frontiers of Environmental Science & Engineering2022，16，8： | 0 |
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