3篇
您的检索式：作者名="Mingmin Deng"
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| 1 | A Practical Process for the Synthesis of Translocator Protein 18kDa Imidazopyridine Ligand显示文摘In this article, an effective feasible method to synthesize translocator protein 18kDa(TSPO) imidazopyridine ligand 7 is discussed. A new procedure for the synthesis of the key intermediate 17 has been developed in four steps(condensation, diazo reaction, hydrolysis, amidation) from 2-aminopyridine 18. The overall yield was increased from 18% to 31.6%. One of the key steps is using activated copper powder as a catalyst in several cycles. Finally, reduction of 17 with Zn dust completed the synthesis of TSPO imidazopyridine ligand 7 in 86% yield. | WEN Meng QU Chunrong SU Xinhui DING Mingmin DENG Zixin HONG Xuechuan | 2014 | Wuhan University Journal of Natural Sciences2014，19，1： | 2 |
| 2 | The influence of Laval nozzle throat size on supersonic molecular beam injection显示文摘In this study, finite element analysis(FEA) has been used to investigate the effects of different Laval nozzle throat sizes on supersonic molecular beam. The simulations indicate the Mach numbers of the molecular stream peak at different positions along the center axis of the beam, which correspond to local minimums of the molecular densities. With the increase of the throat diameter, the first peak of the Mach number increases first and then decreases, while that of the molecular number density increases gradually. Moreover, both first peaks shift progressively away from the throat. At the last part, we discuss the possible applications of our FEA approach to solve some crucial problems met in modern transportations. | Xinkui He Xianfu Feng Mingmin Zhong Fujun Gou Shuiquan Deng Yong Zhao | 2014 | Journal of Modern Transportation2014，22，2： | 1 |
| 3 | A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies显示文摘Intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders,collectively termed as tauopathies,including the most common Alzheimer's disease(AD).Therefore,selectively removing or reducing hyperphosphorylated tau is promising for therapies of AD and other tauopathies.Here,we designed and synthesized a novel DEPhosphorylation TArgeting Chimera(DEPTAC)to specifically facilitate the binding of tau to Ba-subunit-contalning protein phosphatase 2A(PP2A-Ba),the most active tau phosphatase in the brain.The DEPTAC exhibited high efficiency in dephosphorylating tau at multiple AD-associated sites and preventing tau accumulation both in vitro and in vivo.Further studies revealed that DEPTAC significantly improved microtubule assembly,neurite plasticity,and hippocampus-dependent learning and memory in transgenic mice with inducible overexpression of truncated and neurotoxic human tau N368.Our data provide a strategy for selective removal of the hyperphosphorylated tau,which sheds new light for the targeted therapy of AD and related-tauopathies. | Jie Zheng Na Tian Fei Liu Yidian Zhang Jingfen Su Yang Gao Mingmin Deng Linyu Wei Jingwang Ye Honglian Li Jian-Zhi Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
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