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| 1 | Highly-Sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles显示文摘Lanthanide-based upconversion nanoparticles(UCNPs)have been widely explored in various fields,including optical imaging,in recent years.Although earlier work has shown that UCNPs with different lanthanide(Ln3+)dopants exhibit various colors,multicolor-especially in vivo multiplexed biomedical imaging-using UCNPs has rarely been reported.In this work,we synthesize a series of UCNPs with different emission colors and functionalize them with an amphiphilic polymer to confer water solubility.Multicolor in vivo upconversion luminescence(UCL)imaging is demonstrated by imaging subcutaneously injected UCNPs and applied in multiplexed in vivo lymph node mapping.We also use UCNPs for multicolor cancer cell labeling and realize in vivo cell tracking by UCL imaging.Moreover,for the first time we compare the in vivo imaging sensitivity of quantum dot(QD)-based fluorescence imaging and UCNP-based UCL imaging side by side,and find the in vivo detection limit of UCNPs to be at least one order of magnitude lower than that of QDs in our current non-optimized imaging system.Our data suggest that,by virtue of their unique optical properties,UCNPs have great potential for use in highly-sensitive multiplexed biomedical imaging. | Liang Cheng Kai Yang Shuai Zhang Mingwang Shao Shuittong Lee Zhuang Liu | 2010 | Nano Research2010，3，10： | 17 |
| 2 | Comparative study on local and global mechanical properties of bobbin tool and conventional friction stir welded 7085-T7452 aluminum thick plate显示文摘7085-T7452 plates with a thickness of 12 mm were welded by conventional single side and bobbin tool friction stir welding(SS-FSW and BB-FSW, respectively) at different welding parameters. The temperature distribution, microstructure evolution and mechanical properties of joints along the thickness direction were investigated, and digital image correlation(DIC) was utilized to evaluate quantitatively the deformation of different zones during tensile tests. The results indicated that heat-affected zone(HAZ), the local softening region, was responsible for the early plastic deformation and also the fracture location for SS-FSW samples, while a rapid fracture was observed in weld nugget zone(WNZ) before yield behavior for all BB-FSW specimens. The ultimate tensile strength(UTS) of SS-FSW joints presented the highest value of 410 MPa, 82% of the base material, at a rotational speed of 300 rpm and welding speed of 60 mm/min,much higher than that of BB-FSW joints, with a joint efficiency of only 47%. This should be attributed to the Lazy S defect produced by a larger extent of heat input during the BB-FSW process. The whole joint exhibited a much higher elongation than the slices. Scanning electron microscopic(SEM) analysis of the fracture morphologies showed that joints failed through ductile fracture for SS-FSW and brittle fracture for BB-FSW. | Weifeng Xu Yuxuan Luo Wei Zhang Mingwang Fu | 2018 | Journal of Materials Science & Technology2018，34，1： | 7 |
| 3 | A SECOND ORDER MEHROTRA-TYPE PREDICTOR-CORRECTOR ALGORITHM FOR SEMIDEFINITE OPTIMIZATION显示文摘Mehrotra 类型预言者修正者算法是最有效的最初双的 interiorpoint 方法之一。这份报纸论述被 Salahi 建议的第二个顺序 Mehrotra 类型预言者修正者算法的最近的变体的延期,等。(2006 ) 为线性优化。作为牛顿搜索方向基于 NT 方向,为 semidefinite 优化的算法的重复复杂性界限是,这被显示出 { ie1108-1 } ,它类似于为线性优化的相应算法的。 | Mingwang ZHANG | 2012 | Journal of Systems Science & Complexity2012，25，6： | 4 |
| 4 | Genome architecture and tetrasomic inheritance of autotetraploid potato显示文摘Potato(Solanum tuberosum)is the most consumed non-cereal food crop.Most commercial potato cultivars are autotetraploids with highly heterozygous genomes,severely hampering genetic analyses and improvement.By leveraging the state-of-the-art sequencing technologies and polyploid graph binning,we achieved a chromosome-scale,haplotype-resolved genome assembly of a cultivated potato,Cooperation-88(C88).lntra-haplotype comparative analyses revealed extensive sequence and expression differences in this tetraploid genome.We identified haplotype-specific pericentromeres on chromosomes,suggesting a distinct evolutionary trajectory of potato homologous centromeres.Furthermore,we detected double reduction events that are unevenly distributed on haplotypes in 1021 of 1034 selfing progeny,a feature of autopolyploid inheritance.By distinguishing maternal and paternal haplotype sets in C88,we simulated the origin of heterosis in cultivated tetraploid with a survey of 3110 tetra-allelic loci with deleterious mutations,which were masked in the heterozygous condition bytwo parents.This study provides insights into the genomic architecture of autopolyploids and will guide their breeding. | Zhigui Bao Canhui Li Guangcun Li Pei Wang Zhen Peng Lin Cheng Hongbo Li Zhiyang Zhang Yuying Li Wu Huang Mingwang Ye Daofeng Dong Zhukuan Cheng Peter VanderZaag Evert Jacobsen Christian W.B.Bachem Suomeng Dong Chunzhi Zhang Sanwen Huang Qian Zhou | 2022 | Molecular Plant2022，15，7： | 4 |
| 5 | Design of SERS nanoprobes for Raman imaging:materials, critical factors and architectures显示文摘Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surfaceenhanced Raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications.In this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters. | Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 6 | Modeling the Epidemic Trend of the 2019 Novel Coronavirus Outbreak in China显示文摘A new coronavirus disease(COVID-19)with infection by a novel coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally since December 2019.By 22th September 2020,more than 200 countries worldwide have reported about 30 million confirmed cases and more than 950,000 deaths.1 China has reported a total of 85,307(including 2,758 imported)cases and 4,634 deaths. | Mingwang Shen Zhihang Peng Yanni Xiao Lei Zhang | 2020 | The Innovation2020，1，3： | 3 |
| 7 | Interior-Point Algorithm for Linear Optimization Based on a New Kernel Function显示文摘In this paper, we design a primal-dual interior-point algorithm for linear optimization. Search directions and proximity function are proposed based on a new kernel function which includes neither growth term nor barrier term. Iteration bounds both for large-and small-update methods are derived, namely, and . This new kernel function has simple algebraic expression and the proximity function has not been used before. Analogous to the classical logarithmic kernel function, our complexity analysis is easier than the other primal-dual interior-point methods based on logarithmic barrier functions and recent kernel functions. | CHEN Donghai ZHANG Mingwang LI Weihua | 2012 | Wuhan University Journal of Natural Sciences2012，17，1： | 2 |
| 8 | Thermomechanical coupling simulation and experimental study in the isothermal ECAP processing of Ti-6Al-4V alloy显示文摘The thermomechanical coupling simulation of the isothermal equal channel angular pressing(ECAP) of Ti-6Al-4V alloy was conducted.The effect of processing parameters,ECAP pass number and the residual billet on the effective strain,stress and temperature distribution was investigated.Based on the coupling simulation results,it is found that the shear factor,ram speed,deformation temperature,channel intersection angle and residual billet significantly affect the ECAP deformation behaviors.Meanwhile,the experimental study of the isothermal ECAP process of Ti-6Al-4V alloy using route C,in which the repeated rotation angle around the longitudinal billet axis before reinsertion in the die was 180°,were conducted at a deformation temperature of 750°C,a ram speed of 0.3 mm·s-1,an outer arc of curvature of 60° and a channel intersection angle of 120°.Furthermore,a large amount of recrystallization occurs and some prior α phase grains grow in the post-ECAP process of Ti-6Al-4V alloy.The yield strength of post-ECAP Ti-6Al-4V alloy increases compared with that of as-received Ti-6Al-4V alloy. | LI Miaoquan ZHANG Chen LUO Jiao FU Mingwang | 2010 | Rare Metals2010，29，6： | 2 |
| 9 | Optimum designof a 3-RRR planar parallel manipulator with a singularity-freeworkspace显示文摘 | GAO Mingwang ZHANG Xianmin WU Zhi-wei | 2011 | Applied Mechanics and Materials2011，，86： | 1 |
| 10 | Preparation and characterization of composite resin by vinyl chloride grafted onto poly(BA-EHA)/poly(MMA-St)显示文摘 | Mingwang Pan Liucheng Zhang Linzhan Wan Ruiqiang Guo | 2003 | Polymer2003，，23： | 1 |
| 11 | A Wide Neighborhood Arc-Search Interior-Point Algorithm for Convex Quadratic Programming显示文摘In this paper, we propose an arc-search interior-point algorithm for convex quadratic programming with a wide neighborhood of the central path, which searches the optimizers along the ellipses that approximate the entire central path. The favorable polynomial complexity bound of the algorithm is obtained, namely O(nlog(( x^0)~TS^0/ε)) which is as good as the linear programming analogue. Finally, the numerical experiments show that the proposed algorithm is efficient. | YUAN Beibei ZHANG Mingwang HUANG Zhengwei | 2017 | Wuhan University Journal of Natural Sciences2017，22，6： | 1 |
| 12 | Optimum design of a 3 - RRR planar parallel manipulator with a singularity-free workspace显示文摘 | Gao Mingwang Zhang Xianmin Wu Zhiwei | 2011 | Applied Mechanics and Materials2011，86，： | 1 |
| 13 | Preparation and characterization of composite resin by vinyl chloride grafted onto poly (BA-EHA)/poly (MMA-St)显示文摘 | Mingwang Pan Liucheng Zhang Linzhan Wan Ruiqiang Guo | 2003 | Polymer2003，，44： | 1 |
| 14 | Preparation and characterization of composite resin by vinyl chloride grafted onto poly(BA-EHA)/poly (MMA-St)显示文摘 | Pan Mingwang Zhang Liucheng Wan Liuzhan | 2003 | Polymer2003，44，： | 1 |
| 15 | Preparation and characterization of composite resin by vinyl chloride grafted onto poly(BA-EHA)/poly(MMA-St)显示文摘 | Pan Mingwang Zhang Liucheng Wan Linzhan | 2003 | Polymer2003，44，23： | 1 |
| 16 | Preparation and characterization of composite resin by vinyl chloride grafted onto poly(BA-EHA)/poly(MMA-St)显示文摘 | Mingwang Pan Liucheng Zhang Linzhan Wan Ruiqiang Guo | 2003 | Polymer2003，，23： | 1 |
| 17 | Preparation and characterization of composite resin by vinyl chloride grafted onto poly (BA-EHA) /poly (MMA-St) 显示文摘 | PAN Mingwang ZHANG Liucheng WAN Linzhan | 2003 | Polymer2003，44，： | 1 |
| 18 | Preparation and Characterization of Composite Resin by Vinyl Chloride Grafted onto Poly (BA-EHA)/Poly ( MMA- St) 显示文摘 | Pan Mingwang Zhang Liueheng Wan Linzhan | 2003 | Polymer2003，44，： | 1 |
| 19 | n-Butyl Acrylate Based Latex Interpenetrating Polymer Networks Used as Processing Modifiers and Impact Modifiers of Poly (vinyl chloride) 显示文摘 | Zhang Liucheng Pan Mingwang Zhang Jian | 2004 | Journal of Applied Polymer Science2004，91，： | 1 |
| 20 | Rheological Behavior and Thermal Properties of Poly(butyl acrylate-co-2-ethylhexyl acrylate) grafted Vinyl Chloride Resin显示文摘 | Pan Mingwang Zhang Liucheng Yuan Jinfeng | 2005 | Journal of Applied Polymer Science2005，95，2： | 1 |
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