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| 1 | The effect of ride experience on changing opinions toward autonomous vehicle safety显示文摘Autonomous vehicles(AVs)are a promising emerging technology that is likely to be widely deployed in the near future.People's perception on AV safety is critical to the pace and success of deploying the AV technology.Existing studies found that people's perceptions on emerging technologies might change as additional information was provided.To investigate this phenomenon in the AV technology context,this paper conducted real-world AV experiments and collected factors that may associate with people's initial opinions without any AV riding experience and opinion change after a successful AV ride.A number of ordered probit and binary probit models considering data heterogeneity were employed to estimate the impact of these factors on people's initial opinions and opinion change.The study found that people's initial opinions toward AV safety are significantly associated with people's age,personal income,monthly fuel cost,education experience,and previous AV experience.Further,the factors dominating people's opinion change after a successful AV ride include people's age,personal income,monthly fuel cost,daily commute time,driving alone indicator,willingness to pay for AV technology,and previous AV experience.These results provide important references for future implementations of the AV technology.Additionally,based on the inconsistent effects for variables across different models,suggestions for future transportation survey designs are provided. | Xiaowei Shi Zhen Wang Xiaopeng Li Mingyang Pei | 2021 | Communications in Transportation Research2021，1，1： | 0 |
| 2 | Correlation between types of defects/vacancies of Bi2S3 nanostructures and their transient photocurrent显示文摘水晶的 nanostructures 拥有影响他们的物理、化学的性质的缺点 / 空缺。在这方面,材料的电子结构能有效地通过缺点工程被调整;因此,在缺点 / 空缺之间的关联和材料的性质吸引了广泛的注意。这里,我们报导双性人 2 由 nanorod 集会与的 S 3 microspheres 暴露 { 211 } 类型的方面和借助于正电子歼灭 spectrometry 的缺点 / 空缺的集中。我们的研究揭示了那锻烧的温度的增加,从 350 ~ 400 ? ? | Mingyang Liu Luqing Wang Pei Dong Liangliang Dong Xifan Wang Jarin Joyner Xiangjian Wan Boris I. Yakobson Robert Vajtai Pulickel Ajayan PolSpanos | 2017 | Nano Research2017，10，7： | 0 |
| 3 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
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