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| 1 | Inflammation-associated microsatellite alterations:Mechanisms and significance in the prognosis of patients with colorectal cancer显示文摘Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair(MMR). About 15% of sporadic colorectal cancers(CRCs) manifest hypermethylation of the DNA MMR gene MLH1, resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high(MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce a robust protective immune response that can be enhanced with immune checkpoint blockade. More commonly, approximately 50% of sporadic nonMSI-H CRCs demonstrate frameshifts at di-and tetra-nucleotide microsatellites to classify it as MSIlow/elevated microsatellite alterations at selected tetranucleotide repeats(EMAST) as a result of functional somatic inactivation of the DNA MMR protein MSH3 via a nuclear-to-cytosolic displacement. The trigger for MSH3 displacement appears to be inflammation and/or oxidative stress, and unlike MSI-H CRC patients, patients with MSI-L/EMAST CRCs show poor prognosis. These inflammatory-associated microsatellite alterations are a consequence of the local tumor microenvironment, and in theory, if the microenvironment is manipulated to lower inflammation, the microsatellite alterations and MSH3 dysfunction should be corrected. Here we describe the mechanisms and significance of inflammatory-associated microsatellite alterations, and propose three areas to deeply explore the consequences and prevention of inflammation's effect upon the DNA MMR system. | Minoru Koi Stephanie S Tseng-Rogenski John M Carethers | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 7 |
| 2 | 显示文摘 | Minoru T Masanori S | 1993 | J of Materials Eng and Performance1993，2，2： | 1 |
| 3 | Patterns of hyeahh risk behavior among Japanese high school students显示文摘 | Minoru T Tomoko N Seizo S | 2001 | J School Health2001，91，： | 1 |
| 4 | Development of a passive micromixer based on repeated fluid twisting and flattening, and its application of DNA purification 显示文摘 | MINORU S NAE L MASUMI Y | 2005 | Analytical and Bioanalytical Chemistry2005，383，5： | 1 |
| 5 | Electrochemical properties of LiFePO4 thin films prepared by pulsed laser deposition显示文摘 | CHIHIRO Y YASUTOSHI I JEONG S K TAKESHI A MINORU I ZEMPACHI O | 2005 | J Power Sources2005，146，： | 1 |
| 6 | The Dmrt1 expression in sex-reversed gonad of amphibians显示文摘 | Minoru T Masahisa N | 2002 | General & Comparative Endocrinology2002，127，3： | 1 |
| 7 | Development of the electronic instrument transformers for intelligent substation显示文摘 | Minoru S Kazuo K Yasuhiro M | 2003 | TMT&D Review2003，1，1： | 1 |
| 8 | Feasibility of frameless stereotactic high-dose radiation therapy for primary or metastatic liver cancer显示文摘 | Michinao S Minoru U Fuyumi Y | 1998 | Radiosurg1998，1，3： | 1 |
| 9 | A web-based tool for principal component and significance analysis of microarray data显示文摘 | ALEXEI A S DAWOOD B D MINORU S H K | 2005 | Bioinformatics2005，21，10： | 1 |
| 10 | Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients显示文摘 | Kaleb MP Minoru S Annie LC | 2008 | Arthritis Research Therapy2008，10，4： | 1 |
| 11 | Infrared carbonyl absorptions and conformations of methyl-substituted acetones显示文摘 | Minoru H Takeaki H and Hajime S | 1967 | Bulletin of the Chemical Society of Japhan1967，40，10： | 1 |
| 12 | Inheritance mode of mierosatellite DNA markers and their use for kinship estimation in Kuruma prawn Penaeus japonicus 显示文摘 | Takuma S Minoru I Hideshi M | 2002 | Fisheries Science2002，68，： | 1 |
| 13 | Expression,roles,receptors,and regulation of osteopontin in the kidney显示文摘 | Yuansheng X Minoru S Shinichi N | 2001 | Kidney Int2001，60，： | 1 |
| 14 | Recombinant antigens for serodiagnosis of cysticercosis and echinococcosis显示文摘 | Yasuhito S Minoru N Kazuhiro N | 2006 | Parasitology International2006，55，1： | 1 |
| 15 | The Purple leaf (Pl) locus of rice: the Plw allele has a complex organization and includes two genes encoding basic helix-loop-helix proteins involved in anthocyanin biosynthesis显示文摘 | Wataru S Taku O Keisuke K Chikara M Akira S Minoru M Kazuhiko N Masahiko M | 2001 | Plant Cell Physiol2001，42，9： | 1 |
| 16 | Isolation of bacteriophages specific to a fish pathogen, pseudomonas plecoglossicida, as a candidate for diseasecontrol 显示文摘 | Park S C Shimamura I C Minoru F | 2000 | Appl Environ Microbiol2000，66，： | 1 |
| 17 | A novel free radical scavenger,edalavone protects against ciaplatin-induced acute damage in vitro and in vivo显示文摘 | Minoru S Naoki K Sohachi F | 2003 | J Pharmacol Exp Ther2003，305，： | 1 |
| 18 | The effects of oxygen partial pressure on local structural properties for Ga-doped ZnO thin films显示文摘 | Minoru O Toshiyuki S Tetsuya Y | 2006 | Thin Solid Films2006，，494： | 1 |
| 19 | Formation and oxidation of sulfides on pure iron and iron oxides显示文摘 | MASATOSHI W MINORU S TAKESHI I | 2000 | Materials Transactions2000，47，7： | 1 |
| 20 | Microstructures of ZnAl2 O4 formation from coarse and dense AI2O3 and granular ZnO in the presence of LiF显示文摘 | Minoru H Katsumi S Osamu S | 1997 | Solid State Ionics1997，101，： | 1 |
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