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| 1 | 烧伤病房细菌耐药性的分析显示文摘目的 分析笔者单位烧伤病房近 4年来的细菌耐药性。 方法 从本院 1996年~ 1999年烧伤患者血培养阳性及创面分离出的细菌 ,其中 5 0株以上者 5种 ,用纸片琼脂扩散法进行药敏试验。并以美国国家临床实验室标准委员会 (NCCLS)公布的数值作为判断耐药标准。应用双纸片协同试验检测 45株肺炎克雷伯菌的超广谱 -内酰胺酶 (ESBLs)。 结果 仅万古霉素对金黄色葡萄球菌有效。亚胺培南对大肠埃希菌、阴沟肠杆菌、肺炎克雷伯菌有效 ,而仅多粘菌素 -B对铜绿假单胞杆菌有效。 45株肺炎克雷伯菌中ESBLs阳性者有 38株 ,ESBLs的发生率为 84.4%。 结论笔者医院烧伤病房的细菌耐药率甚高 ,这可能是由于 β -内酰胺酶的产生 ,特别是ESBLs发生率甚高所致 ,亚胺培南依然对ES BLs稳定 ,抗菌效能佳 ;但复合 β-内酰胺酶抑制剂的抗生素作用已日趋减弱。铜绿假单胞菌对亚胺培南的耐药率正逐年增高 ,可能是由于大量使用该药 ,引起菌株产生一种新的由质粒传递的金属 β -内酰胺酶 ,细菌外膜蛋白产生减少与通透性的改变 。 | 许小敏 张民权 廖萍华 Xu Xiaomin Zhang Minquan LIAO Pinghua | 2001 | 中华烧伤杂志2001，17，2： | 26 |
| 2 | Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice显示文摘Mecobalamin,a form of vitamin B12 containing a central metal element(cobalt),is one of the most important mediators of nervous system function.In the clinic,it is often used to accelerate recovery of peripheral nerves,but its molecular mechanism remains unclear.In the present study,we performed sciatic nerve crush injury in mice,followed by daily intraperitoneal administration of mecobalamin(65 μg/kg or 130 μg/kg) or saline(negative control).Walking track analysis,histomorphological examination,and quantitative real-time PCR showed that mecobalamin significantly improved functional recovery of the sciatic nerve,thickened the myelin sheath in myelinated nerve fibers,and increased the cross-sectional area of target muscle cells.Furthermore,mecobalamin upregulated m RNA expression of growth associated protein 43 in nerve tissue ipsilateral to the injury,and of neurotrophic factors(nerve growth factor,brain-derived nerve growth factor and ciliary neurotrophic factor) in the L4–6 dorsal root ganglia.Our findings indicate that the molecular mechanism underlying the therapeutic effect of mecobalamin after sciatic nerve injury involves the upregulation of multiple neurotrophic factor genes. | Lin Gan Minquan Qian Keqin Shi Gang Chen Yanglin Gu Wei Du Guoxing Zhu | 2014 | Neural Regeneration Research2014，9，22： | 11 |
| 3 | Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms显示文摘Early childhood caries(ECC)is a public healthcare concern that greatly reduces the quality of life of young children.As a leading factor of ECC,cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides(EPSs),creating an acidic and protected microenvironment.Antimicrobial photodynamic therapy(aPDT)is a noninvasive,painless,and efficient therapeutic approach that is suitable for treating ECC.However,due to the hyperfine structure of cariogenic biofilms,most photosensitizers(PSs)could not access and penetrate deeply in biofilms,which dramatically hamper their efficiency in the clinic.Herein,bioresponsive nanoparticle loaded with chlorin e6(MPP-Ce6)is developed,which largely increases the penetration depth(by over 75%)and retention(by over 100%)of PS in the biofilm compared with free Ce6.Furthermore,MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation.A rampant caries model is established to mimic ECC in vivo,where the population of cariogenic bacteria is decreased to 10%after MPP-Ce6-mediated aPDT.Importantly,the number and severity of carious lesions are efficiently reduced via Keyes’scoring and micro-CT analysis.This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC. | Danfeng Liu Xianbin Ma Yaoting Ji Rourong Chen Shuhui Zhou Hantao Yao Zichen Zhang Mengjie Ye Zhigang Xu Minquan Du | 2022 | Bioactive Materials2022，7，8： | 2 |
| 4 | The existence of balanced (v, {3,6}, 1) difference families显示文摘Optimal frequency-hopping sequences can be constructed from cyclic (v, K, 1)-PBDs. A (v, K, 1) difference family can be used to construct a (v, K, 1)-PBD. A lot of work has been done on the existence of (v, k, 1) difference families when K = {k} is a singleton. For K = {3, 4}, it is proved that for each prime power v ≡ 1 (mod 18) and v 19, there exists a balanced (v, K, 1) difference family. In this paper, it is proved that there exists a balanced (v, {3, 6}, 1) difference family for each prime power v ≡ 1 (mod 36) and v 37. An infinite class of optimal frequency-hopping sequence is then obtained. | WU DianHua CHENG MinQuan CHEN ZhiLin LUO HaiPeng | 2010 | Science China(Information Sciences)2010，53，8： | 2 |
| 5 | Synthesis in situ of 2,2′-dipyridyl-Tb(iii) complexes in silica gel显示文摘 | Qian Guodong Wang Minquan Wang Mang Fan Xianping Hong Zhanglian | 1997 | Journal of Materials Science Letters1997，，4： | 1 |
| 6 | In vitro activity of eugenol against Candida albicans biofilms 显示文摘 | Miao He Minquan Du Mingwen Fan | 2007 | Mycopathologia2007，163，3： | 1 |
| 7 | Pressurized solvent extraction of wheat germ oil显示文摘 | Nurhan Turgut Dunford Minquan Zhang | 2003 | Food Research Interna- tional2003，36，： | 1 |
| 8 | Synthesis in situ of 2,2′-dipyridyl-Tb(iii) complexes in silica gel显示文摘 | Qian Guodong Wang Minquan Wang Mang Fan Xianping Hong Zhanglian | 1997 | Journal of Materials Science Letters1997，，4： | 1 |
| 9 | Pressurized solvent extraction of wheat germ oil显示文摘 | NURHAN T D MINQUAN Z | 2003 | Food Research International2003，36，： | 1 |
| 10 | Pressurized solvent extraction of wheat germ oil显示文摘 | Nurhan Turgut Dunforda Minquan Zhang | 2003 | Food Research International2003，，36： | 1 |
| 11 | Basic principles for observing the photosensitizer role of graphene in the graphene-semicon- ductor Composite Photocatalyst from a Case Study on Graphene-ZnO显示文摘 | YANG Minquan XU Yijun | 2013 | J Phys Chem C2013，117，21： | 1 |
| 12 | Land consolidation and productivity in Chinese household crop production显示文摘 | Wu Ziping Minquan Liu John Davis | | 0，，16： | 1 |
| 13 | Study on the water environmental capacity and the sewage control of the Sushui River显示文摘 | BAI Jizhong YANG Jianming FENG Minquan | 2012 | Advanced Materials Research2012，43，34344354364374： | 1 |
| 14 | Luminescence behavior of Eu^3+ doped LaF3 nanoparticles 显示文摘 | Pi Daibo Wang Feng Fan Xianping Wang Minquan Zhang Yong | 2005 | Spectrochimica Acta Part A2005，61，1112： | 1 |
| 15 | Research on fluorescence spectra and structure of single-phase4SrO ·7A12O3: Eu2+ phosphor prepared by solid-state reaction method显示文摘 | Wang Dong Lu Guanglie | 1998 | Materials Science and Engineering1998，57，： | 1 |
| 16 | One-pot synthesis of chitosan/LaF3: Eu^3+ nanocrystals for bio-applications 显示文摘 | Wang Feng Zhang Yong Fan Xianping Wang Minquan | 2006 | Nanotechnology2006，17，5： | 1 |
| 17 | On Anti-collusion Codes and Detection Algorithms for Multimedia Fingerprinting显示文摘 | Cheng Minquan Miao Ying | 2011 | IEEE Transactions on Information Theory2011，57，7： | 1 |
| 18 | Land consolidation and productivity in Chinese household crop production显示文摘 | Ziping Wu Minquan Liu John Davis | 2004 | China Economic Review2004，，1： | 1 |
| 19 | In vitro activity of eugenol against Candida albicans biofilms 显示文摘 | Miao He Minquan Du Mingwen Fan | 2007 | Mycopathologia2007，163，3： | 1 |
| 20 | 显示文摘 | Qiao Xvsheng Fan Xianping Wang Minquan | 2004 | Opt Mater2004，27，： | 1 |
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