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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 4 | Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2 ( E ) -nonenal in human monocytic THP-1 ceils显示文摘 | MIRANDA CL REED RL KUIPER HC | 2009 | Chem Res Toxicol2009，22，5： | 1 |
| 5 | Association between periodontitis and gestational diabetes mellitus:a case-control study显示文摘 | Esteves LR Miranda CL Costa FO | 2013 | J Periodontol2013，84，9： | 1 |
| 6 | Effects of chlorobenzenes on hepatic porphyrin and drug metabolism in chick embryo and day-old chick 显示文摘 | Miranda CL Wang JL Henderson MC | 1984 | Res Commun Chem Pathol Pharmac1984，46，1： | 1 |
| 7 | Chemistry and Biology of Hop Flavonoids显示文摘 | Stevens J Miranda CL Buhler DR | 1998 | J Am Soc Brew Chem1998，56，4： | 1 |
| 8 | Antiproliferative and cytotoxic effects of prenylated flavonoids from hops(Humuluslupulus) in human cancer cell lines显示文摘 | MIRANDA CL STEVENS JF HELMRICH A | 1999 | Food Chem Toxicol1999，37，4： | 1 |
| 9 | Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humuluslnpulus) in human cancer cell lines 显示文摘 | Miranda CL Stevens JF Helmrich A | 1999 | Food Chem toxicol1999，37，4： | 1 |
| 10 | (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance显示文摘 | Oliver CL Miranda MB Shangary S | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 11 | Gossypol acts direetly on the mitochondria to overcome Bcl-2-and Bcl-X (L)-mediated apoptosis resistance显示文摘 | Oliver CL Miranda MB ShanGLry S | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 12 | Inhi- bition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: alpha-naphthoflavone, beta-naphthoflavone and trout CYP1A1 peptide antibody 显示文摘 | TAKAHASH1 N MIRANDA CL HENDERSON MC | 1995 | Comp Biochem Physiol C Pharmacol Toxicol Endocrinol1995，110，3： | 1 |
| 13 | (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2-and Bcl-X(L)-mediated apoptosis resistance显示文摘 | Oliver CL Miranda MB Shangary S | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 14 | Differential induction of hepatic drugmetabolizing enzymes in Japanese quail by 1,2,4-trichlorobenzene显示文摘 | 22,Miranda CL Wang JL Henderson MC | 1983 | Toxicology1983，28，12： | 1 |
| 15 | Effects of chlorobenzenes on hepaticporphyrin and drug metabolism in chick embryo and day-old chick 显示文摘 | 23,Miranda CL Wang JL Henderson MC | 1984 | Res Commun ChemPathol Pharmaclo1984，46，1： | 1 |
| 16 | ( - )-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-xL-mediated apoptosis resistance 显示文摘 | Oliver CL Miranda MB Shangary S | 2005 | Mol Cancer T- her2005，4，1： | 1 |
| 17 | Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro suseeptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America显示文摘 | Dalla Costa ER Ribeiro MO Silva MS Arnold LS Rostirolla DC Cafrune PI Espinoza RC Palaci M Telles MA Ritaeeo V Suffys PN Lopes ML Campelo CL Miranda SS Kremer K da Silva PE Fonseea Lde S Ho JL Kritski AL Rossetti ML | 2009 | BMC Microbiol2009，9，： | 1 |
| 18 | Identificationand in vitro biological activities of hop proanthocyanidins :Inhibition of nNOS activity and scavenging of reactive nitrogenspecies显示文摘 | Stevens JF Miranda CL Wolthers KR ei al | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 19 | Enterobacter hormaechei bloodstream infection at three neonatal intensive care units in Brazil显示文摘 | da Silva CL Miranda LE Moreira BM | 2002 | Pediatr Infect Dis J2002，21，2： | 1 |
| 20 | In vitro inhibition of human P450 enzymes by prenylated flavonids from hops,Humulus lupulus显示文摘 | Henderson MC Miranda CL Stevens JF | 2000 | Xenobiotica2000，30，3： | 1 |
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