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| 1 | Scavenger receptor BI: A multi-purpose player in cholesterol and steroid metabolism显示文摘Scavenger receptor class B type Ⅰ (SR-BI) is an important member of the scavenger receptor family of integral membrane glycoproteins. This review highlights studies in SR-BI knockout mice, which concern the role of SR-BI in cholesterol and steroid metabolism. SR-BI in hepatocytes is the sole molecule involved in selective uptake of cholesteryl esters from high-density lipoprotein (HDL). SR-BI plays a physiological role in binding and uptake of native apolipoprotein B (apoB)-containing lipoproteins by hepatocytes, which identif ies SR-BI as a multipurpose player in lipid uptake from the blood circulation into hepatocytes in mice. In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is eff iciently coupled to the synthesis of glucocorticoids (i.e. corticosterone). SR-BI knockout mice suffer from adrenal glucocorticoid insuff iciency, which suggests that functional SR-BI protein is necessary for optimal adrenal steroidogenesis in mice. SR-BI in macrophages plays a dual role in cholesterol metabolism as it is able to take up cholesterol associated with HDL and apoBcontaining lipoproteins and can possibly facilitate cholesterol efflux to HDL. Absence of SR-BI is associated with thrombocytopenia and altered thrombosis susceptibility, which suggests a novel role for SR-BI in regulating platelet number and function in mice. Transgenic expression of cholesteryl ester transfer protein in humanized SR-BI knockout mice normalizes hepatic delivery of HDL-cholesteryl esters. However, other pathologies associated with SR-BI def iciency, i.e. increased atherosclerosis susceptibility, adrenal glucocorticoid insuffi ciency, and impaired platelet function are not normalized, which suggests an important role for SR-BI in cholesterol and steroid metabolism in man. In conclusion, generation of SR-BI knockout mice has signif icantly contributed to our knowledge of the physiological role of SR-BI. Studies using these mice have identif ied SR-BI as a multi-purpose player in cholesterol and steroid metabolism because it has distinct roles in reverse cholesterol transport, adrenal steroidogenesis, and platelet function. | Menno Hoekstra Theo JC Van Berkel Miranda Van Eck | 2010 | World Journal of Gastroenterology2010，16，47： | 11 |
| 2 | Giant cell tumors of bone:nonsurgical factors associated with local recurrence显示文摘 | Teixeira LE Vilela JC Miranda RH | 2014 | Acta Orthop Traumatol Turc2014，48，2： | 1 |
| 3 | Oral cancer case finding program (OCCFP)显示文摘 | Santana JC Delgado L Miranda J | 1997 | Oral Oncol1997，33，1： | 1 |
| 4 | Spinal synergy between nonselective cyclooxygenase inhibitors and morphine antinociception in mice显示文摘 | Miranda HF Prieto JC Pinardi G | 2005 | Brain Res2005，1049，2： | 1 |
| 5 | Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain显示文摘 | Miranda HF Puig MM Prieto JC | 2006 | Pain2006，121，12： | 1 |
| 6 | Meyer's loop and the optic radiations in the transsylvian approach to the mediobasal temporallobe 显示文摘 | Choi C Rubino PA Fernandez Miranda JC | 2006 | Neurosurgery2006，59，42： | 1 |
| 7 | Endoscopic endonasal surgery for craniopharyngio mas:surgical outcome in 64 patients显示文摘 | Koutourousiou M Gardner PA Fernanderz Miranda JC | 2013 | J Neurosurg2013，119，5： | 1 |
| 8 | Finite element analysis of weakened roots restored with composite resin and posts 显示文摘 | Miranda CS Gabrielli JC Rodrigues G | 2009 | Dent Mater J2009，28，： | 1 |
| 9 | Meyer' s loop and the optic radiations in the transsylvian approach to the mediobasal temporal lobe显示文摘 | Choi C Rubino PA Fernandez Miranda JC | 2006 | Neurosurgery2006，59，4： | 1 |
| 10 | Phagocytosis and nitric oxide levels in rheumatic inflammatory states in elderly women显示文摘 | Paino IM Miranda JC Marzocchi-Maehado CM | 2011 | J Clin Lab Anal2011，25，1： | 1 |
| 11 | Different aspects of magnetic resonance imaging of muscles between dermatomyositis and polymyositis 显示文摘 | Miranda SS Alvarenga D Rodrignes JC | 2014 | Rev Bras Reumatol2014，54，4： | 1 |
| 12 | The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure显示文摘 | MIRANDA F JIMENEZ JC CEDILLO LN | 2009 | Pharmacol Biochem Behav2009，93，1： | 1 |
| 13 | An 18-week, prospective, randomized, double-blind, muhicenter study of amlodipine/ramipril combination versus amlodipine monotherapy in the treatment of hypertension: the assessment of combination therapy of amlodipine/ramipril (ATAR) study显示文摘 | Miranda RD Mion D Jr Rocha JC | 2008 | Clin Ther2008，30，9： | 1 |
| 14 | Audiovestibular manifestations in patients with limited systemic sclerosis and centromere protein-B (CENP - B) antibodies显示文摘 | Amor- Dorado JC Arias - Nunez MC Miranda - Filloy GA | 2008 | Medicine(Baltimore)2008，87，： | 1 |
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