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| 1 | Pathogenic mechanisms of pancreatitis显示文摘Pancreatitis is inflammation of pancreas and caused by a number of factors including pancreatic duct obstruction, alcoholism, and mutation in the cationic trypsinogen gene. Pancreatitis is represented as acute pancreatitis with acute inflammatory responses and; chronic pan-creatitis characterized by marked stroma formation with a high number of infiltrating granulocytes(such as neutrophils, eosinophils), monocytes, macrophages and pancreatic stellate cells(PSCs). These inflammatory cells are known to play a central role in initiating and promoting inflammation including pancreatic fibrosis, i.e., a major risk factor for pancreatic cancer. A number of inflammatory cytokines are known to involve in pro-moting pancreatic pathogenesis that lead pancreatic fibrosis. Pancreatic fibrosis is a dynamic phenomenon that requires an intricate network of several autocrine and paracrine signaling pathways. In this review, we have provided the details of various cytokines and molecular mechanistic pathways(i.e., Transforming growth factor-β/SMAD, mitogen--activated protein kinases, Rho kinase, Janus kinase/signal transducers and activators, and phosphatidylinositol 3 kinase) that have a critical role in the activation of PSCs to promote chronic pancreatitis and trigger the phenomenon of pancreatic fibrogenesis. In this review of literature, we discuss the involvement of several pro-inflammatory and anti-inflammatory cytokines, such as in interleukin(IL)-1, IL-1β, IL-6, IL--8 IL-10, IL-18, IL--33 and tumor necrosis factor-α, in the pathogenesis of disease. Our review also highlights the significance of several experimental animal models that have an important role in dissecting the mechanistic pathways operating in the development of chronic pancreatitis, including pancreatic fibrosis. Additionally, we provided several intermediary molecules that are involved in major signaling pathways that might provide target molecules for future therapeutic treatment strategies for pancreatic pathogenesis. | Murli Manohar Alok Kumar Verma Sathisha Upparahalli Venkateshaiah Nathan L Sanders Anil Mishra | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 21 |
| 2 | 提高认知能力的印度传统草药土丁桂(英文)显示文摘土丁桂属草药是作用于中枢神经系统的印度传统药物,特别是对促进记忆和改善智力有较好疗效。从印度传统医学和梵语文献中提取的大量信息提示,冠以土丁桂属草药名称的植物类别共4种:旋花科田旋花、旋花科土丁桂、蝶形花科蝴蝶花豆和龙胆科穿心草。这些草药名称均在古代文献中有所记载,可单独使用或与其他药材组合成各种草药处方。本文就现有的科学信息,如土丁桂属不同植物来源物种的生药学特征、化学成分、药理作用、临床前及临床应用等方面进行述评,以期为科学地应用土丁桂提供依据。此外,还可根据不同植物来源土丁桂属草药的不同功效进行鉴别应用。 | Neeraj Kumar SETHIYA Alok NAHATA Sri Hari MISHRA Vinod Kumar DIXIT | 2009 | 中西医结合学报2009，7，11： | 2 |
| 3 | Upper ocean high resolution regional modeling of the Arabian Sea and Bay of Bengal显示文摘In this paper, effort is made to demonstrate the quality of high-resolution regional ocean circulation model in realistically simulating the circulation and variability properties of the northern Indian Ocean(10°S–25°N,45°–100°E) covering the Arabian Sea(AS) and Bay of Bengal(BoB). The model run using the open boundary conditions is carried out at 10 km horizontal resolution and highest vertical resolution of 2 m in the upper ocean.The surface and sub-surface structure of hydrographic variables(temperature and salinity) and currents is compared against the observations during 1998–2014(17 years). In particular, the seasonal variability of the sea surface temperature, sea surface salinity, and surface currents over the model domain is studied. The highresolution model's ability in correct estimation of the spatio-temporal mixed layer depth(MLD) variability of the AS and BoB is also shown. The lowest MLD values are observed during spring(March-April-May) and highest during winter(December-January-February) seasons. The maximum MLD in the AS(BoB) during December to February reaches 150 m (67 m). On the other hand, the minimum MLD in these regions during March-April-May becomes as low as 11–12 m. The influence of wind stress, net heat flux and freshwater flux on the seasonal variability of the MLD is discussed. The physical processes controlling the seasonal cycle of sea surface temperature are investigated by carrying out mixed layer heat budget analysis. It is found that air-sea fluxes play a dominant role in the seasonal evolution of sea surface temperature of the northern Indian Ocean and the contribution of horizontal advection, vertical entrainment and diffusion processes is small. The upper ocean zonal and meridional volume transport across different sections in the AS and BoB is also computed. The seasonal variability of the transports is studied in the context of monsoonal currents. | Dwivedi Suneet Mishra Alok Kumar Srivastava Atul | 2019 | Acta Oceanologica Sinica2019，38，5： | 1 |
| 4 | Re-estimation and comparisons of alternative accounting based bankruptcy prediction models for Indian companies显示文摘Background:The suitability and performance of the bankruptcy prediction models is an empirical question.The aim of this paper is to develop a bankruptcy prediction model for Indian manufacturing companies on a sample of 208 companies consisting of an equal number of defaulted and non-defaulted firms.Out of 208 companies,130 are used for estimation sample,and 78 are holdout for model validation.The study reestimates the accounting based models such as Altman EI(Journal of Finance 23:19189-209,1968)Z-Score,Ohlson JA(Journal of Accounting Research 18:109-131,1980)Y-Score and Zmijewski ME(Journal of Accounting Research 22:59-82,1984)X-Score model.The paper compares original and re-estimated models to explore the sensitivity of these models towards the change in time periods and financial conditions.Methods:Multiple Discriminant Analysis(MDA)and Probit techniques are employed in the estimation of Z-Score and X-Score models,whereas Logit technique is employed in the estimation of Y-Score and the newly proposed models.The performance of all the original,re-estimated and new proposed models are assessed by predictive accuracy,significance of parameters,long-range accuracy,secondary sample and Receiver Operating Characteristic(ROC)tests.Results:The major findings of the study reveal that the overall predictive accuracy of all the three models improves on estimation and holdout sample when the coefficients are re-estimated.Amongst the contesting models,the new bankruptcy prediction model outperforms other models.Conclusions:The industry specific model should be developed with the new combinations of financial ratios to predict bankruptcy of the firms in a particular country.The study further suggests the coefficients of the models are sensitive to time periods and financial condition.Hence,researchers should be cautioned while choosing the models for bankruptcy prediction to recalculate the models by looking at the recent data in order to get higher predictive accuracy. | Bhanu Pratap Singh Alok Kumar Mishra | 2016 | Financial Innovation2016，2，1： | 0 |
| 5 | Near-saturated soil hydraulic conductivity and pore characteristics as influenced by conventional and conservation tillage practices in North-West Himalayan region,India显示文摘Tillage plays an important role in modifying soil hydraulic properties.The objective of the present study was to evaluate the effect of conservation tillage practices in a maize-wheat cropping system on nearsaturated soil hydraulic properties and pore characteristics in the North-West Himalayan region,India.Three treatments viz.conventional tillage(CT),minimum tillage(MT),and zero tillage(ZT)were evaluated in terms of field saturated hydraulic conductivity(ks),unsaturated hydraulic conductivity k(h),the inverse of capillary length(a),flow-weighted mean pore radius(r0),numbers of pores per square meter(n0)and water-conducting macroporosity(Ɛ).The above hydraulic conductivity and pore characteristics were derived from steady-state water flux(q)measured using hood infiltrometer at 0,1,and3 cm pressure head for each treatment after seven years of establishment of this tillage experiment.Results revealed significantly(p<0.05)higher values of ks,k(h),a,andƐin ZT as compared with CT.MT had intermediate values.Higher a values suggested a greater gravity-dominated flow under ZT and MT as compared with CT.Analysis of r0 values indicated better connectivity of pores in ZT and MT as compared with CT.Macropore flow suggested that on average pore radii,>0.50 mm conducted about 63.60,68.01,and 75.97%of total flow(at 0 cm pressure head)in the corresponding water-conducting macroporosity of 0.00030,0.00044,and 0.00069%of soil volume under CT,MT,and ZT,respectively.Overall,zero-tillage based agriculture system was found to improve near-saturated soil hydraulic properties. | Deepak Singh Alok Kumar Mishra Sridhar Patra Sankar Mariappan Nisha Singh | 2021 | International Soil and Water Conservation Research2021，9，2： | 0 |
| 6 | Spatial variability of soil hydraulic and physical properties in erosive sloping agricultural fields显示文摘It is essential to minimize soil quality degradation in sloping agricultural fields through stabilization and improvement of soil hydraulic properties using sustainable soil management.This study aimed to analyze the impact of different tillage practices,including conventional tillage(CT),minimum tillage(MT),and zero tillage(ZT),on soil hydraulic conductivity in a sloping agricultural field under maizeewheat rotation.The results showed that the highest runoff volume(257.40 m3),runoff coefficient(42.84%),and soil loss(11.3 t)were observed when the CT treatment was applied.In contrast,the lowest runoff volume(67.95 m3),runoff coefficient(11.35%),and soil loss(1.05 t)were observed when the ZT treatment was adopted.The soil organic carbon and aggregate mean weight diameter were found to be significantly greater(with mean values of 0.79%and 1.19 mm,respectively)with the ZT treatment than with the CT treatment.With the tilled treatments(CT and MT),substantial changes in the saturated soil hydraulic conductivity(ks),near-saturated soil hydraulic conductivity(k),and water-conducting porosity(ε)were observed between two crop seasons.These three soil parameters were significantly higher in the period after maize harvesting than in the wheat growing period.In contrast,no significant difference in these soil parameters was found when the untilled treatment(ZT)was carried out.With regard to the slope positions,ks,k,andεshowed different behaviors under different treatments.The toe slope position showed significantly lower ks andεvalues than the summit and middle slope positions.Of the evaluated tillage practices,ZT was found to be the most promising means to improve the soil hydro-physical properties and effectively reduce surface runoff and soil erosion. | Deepak Singh Alok Kumar Mishra Sridhar Patra Sankar Mariappan Nisha Singh Saswat Kumar Kar | 2023 | Water Science and Engineering2023，16，1： | 0 |
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