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| 1 | En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer显示文摘AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were recorded.RESULTS The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had clear resection margins(R0). The median follow-up time was 77 mo. During this period, two patients with tumor thrombosis died from liver metastasis. The overall survival rates were 80% at 1 year and 60% at 5 years. All patients with node-negative status(n = 2) survived for more than seven years.CONCLUSION This study showed that the long-term survival is possible for patients with LARCC if RHCPD is performed successfully, particularly in those with node-negative status. | Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa Kosuke Ichida Fumiaki Watanabe Takaharu Kato Yasuyuki Miyakura Koichi Suzuki Toshiki Rikiyama | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Hepatic portal venous gas after endoscopy in a patient with anastomotic obstruction显示文摘A 72-year-old male underwent a laparoscopic low anterior resection for advanced rectal cancer.A diverting loop ileostomy was constructed due to an anastomotic leak five days postoperatively.Nine months later,colonoscopy performed through the stoma showed complete anastomotic obstruction.The mucosa of the proximal sigmoid colon was atrophic and whitish.Ten days after the colonoscopy,the patient presented in shock with abdominal pain.Abdominal computed tomography scan showed hepatic portal venous gas(HPVG) and a dilated left colon.HPVG induced by obstructive colitis was diagnosed and a transverse colostomy performed emergently.His subsequent hospital course was unremarkable.Rectal anastomosis with diverting ileostomy is often performed in patients with low rectal cancers.In patients with anastomotic obstruction or severe stenosis,colonoscopy through diverting stoma should be avoided.Emergent operation to decompress the obstructed proximal colon is necessary in patients with a blind intestinal loop accompanied by HPVG. | Ai Sadatomo Koji Koinuma Rihito Kanamaru Yasuyuki Miyakura Hisanaga Horie Alan T Lefor Yoshikazu Yasuda | 2015 | World Journal of Gastrointestinal Surgery2015，7，2： | 2 |
| 3 | Extensive but hemiallelic methylation of the hmlhl promoter region in early- onset sporadic colon cancers with microsatellite instability 显示文摘 | Miyakura Y Sugano K Akasu T | 2004 | Clin Gastroenterol Hepatol2004，2，2： | 1 |
| 4 | Extensive methylation of hm1H1 promoter region predominates in proximal coloncancer with microsatellite instability显示文摘 | Miyakura Y Sugano K Konishi F | 2001 | Gastroenterology2001，121，6： | 1 |
| 5 | Bending and torsional vibration control of a flexible plate structure using H∞based robust control low 显示文摘 | Kar I N Miyakura T Seto K | 2000 | IEEE Transactions on Control System Technology2000，8，3： | 1 |
| 6 | Mutations of BRAF are associated with extensive MLH1 promoter methylation in sporadic color-ectal carcinomas显示文摘 | Koinuma K Shitoh K Miyakura Y | 2004 | Cancer2004，108，： | 1 |
| 7 | Appropriate operation for elderly Coloretal Cancer Patients based upon an assessment of preoperative risk faetors显示文摘 | Miyakura Y Togashi K Konishi F | 2003 | surg Today2003，33，： | 1 |
| 8 | Oral finasteride improved the quality of life of androgenetic alopeeia patients 显示文摘 | Yamazaki M Miyakura T Uchiyama M | 2011 | J Dermatol2011，38，8： | 1 |
| 9 | Bending and torsional vibration control of a flexible plate structure using H∞-based robust control law显示文摘 | KARI N MIYAKURA T SETO K | 2000 | IEEE Transactions on Control Systems Technology2000，8，3： | 1 |
| 10 | Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas 显示文摘 | Koinuma K Shitoh K Miyakura Y | 2004 | Int J Cancer2004，108，： | 1 |
| 11 | Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspase-8 activity in H202-induced human HUC-F2 fibroblasts显示文摘 | Shimizu Y Miyakura R Otsuka Y | 2015 | Redox Rep2015，20，2： | 1 |
| 12 | Microsatellite instability as a marker in predicting metachronous multiple colorectal carcinomas after surgery:a cohort-like study显示文摘 | Shitoh K Konishi F Miyakura Y | | 0，，： | 1 |
| 13 | Appropriate operation for elderly colorectal cancer patients based upon an assessment of preoperative risk factors显示文摘 | Miyakura Y Togashi K Konishi F | 2003 | Surg Today2003，33，7： | 1 |
| 14 | Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability 显示文摘 | Miyakura Y | 2001 | Gastroenterology2001，121，： | 1 |
| 15 | Extensive met hylation of hML H 1 promoter region predominates in proximal colon cancer with microsatellite instability 显示文摘 | Miyakura Y Sugano K Konishi F | 2001 | Gastroenterology2001，121，6： | 1 |
| 16 | Concurruent Mutations of K-ras Oncogene at Codons 12 and 22 in Colon cancer显示文摘 | MIYAKURA Y SUGANO K FUKAYAMA N | 2002 | Jpn J Clin Oncol2002，32，6： | 1 |
| 17 | A robust spline filter on the basis of L2-norm显示文摘 | Goto T Miyakura J Umeda K | 2005 | Precision Engineering2005，29，2： | 1 |
| 18 | Bending the torsional vibration control of a flexible plate structure using H∞-based robust control law显示文摘 | Kar I N Miyakura T Seto K | 2000 | IEEE transactions on control systems technology2000，8，： | 1 |
| 19 | Extensive but hemiallelic methylation of the h MLH 1 promoter region in early-onset sporadic colon cancers with microsatellite instability显示文摘 | Yasuyuki Miyakura Kokichi Sugano Takayuki Akasu Teruhiko Yoshida Masato Maekawa Soh Saitoh Hideyuki Sasaki Tadashi Nomizu Fumio Konishi Shin Fujita Yoshihiro Moriya Hideo Nagai | 2004 | Clinical Gastroenterology and Hepatology2004，，2： | 1 |
| 20 | A Robust Spline Filter on the Basis of L2-Norm显示文摘 | Goto T Miyakura J Umeda K | 2005 | Precision En gineering2005，29，2： | 1 |
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