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| 1 | Comparison of different diagnostic methods in infants with Cholestasis显示文摘AIM: To evaluate different methods in differentiating idiopathic neonatal hepatitis from biliary atresia. METHODS: Sixty-five infants with cholestatic jaundice and final diagnosis of idiopathic neonatal hepatitis and biliary atresia were studied prospectively from September 2003 to March 2006. A thorough history and physical examination were undertaken and the liver enzymes were examined. All cases underwent abdominal ultrasonography, hepatobiliary scintigraphy, and percutaneous liver biopsy. The accuracy, sensitivity, specificity and predictive values of these various methods were compared. RESULTS: There were 34 girls and 31 boys, among them 46 subjects had idiopathic neonatal hepatitis (age, 61 ± 17 d) and 19 had biliary atresia (age, 64 ± 18 d). The mean age at onset of jaundice was significantly lower in cases of biliary atresia when compared to idiopathic neonatal hepatitis cases (9 ± 13 d vs 20 ± 21 d; P = 0.032). The diagnostic accuracy of different methods was as follows: liver biopsy, 96.9%; clinical evaluation, 70.8%; ultrasonography, 69.2%; hepatobiliary scintigraphy, 58.5%; and liver enzymes, 50.8%.CONCLUSION: Our results indicate that clinical evaluation by an experienced pediatric hepatologist and a biopsy of the liver are considered as the most reliable methods to differentiate idiopathic neonatal hepatitis and biliary atresia. | Seyed Mohsen Dehghani Mahmood Haghighat Mohammad Hadi Imanieh Bita Geramizadeh | 2006 | World Journal of Gastroenterology2006，12，36： | 14 |
| 2 | Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level显示文摘AIM To investigate incidence and survival of post-transplant lymphoproliferative disorder(PTLD) patients after liver transplantation. METHODS A cross-sectional survey was conducted among patients who underwent liver transplantation at Shiraz Transplant Center(Shiraz, Iran) between August 2004 and March 2015. Clinical and laboratory data of patients were collected using a data gathering form. RESULTS There were 40 cases of PTLD in the pediatric age group and 13 cases in the adult group. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The post-PTLD survival of patients at 6 mo was 75.1% ± 6%, at 1 year was 68.9% ± 6.5% and at 5 years was 39.2% ± 14.2%. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients(OR = 1.07, 95%CI: 1.006-1.15, P = 0.032). A serum tacrolimus level over 11.1 ng/mL was predictive of post PTLD survival(sensitivity = 90%, specificity = 52%, area under the curve = 0.738, P = 0.035). CONCLUSION Incidence of PTLD in our liver transplant patients is comparable to other centers. Transplant physicians may consider adjustment of tacrolimus dose to maintain its serum level below this cutoff point. | Ahad Eshraghian Mohammad Hadi Imanieh Seyed Mohsen Dehghani Saman Nikeghbalian Alireza Shamsaeefar Frouzan Barshans Kourosh Kazemi Bita Geramizadeh Seyed Ali Malek-Hosseini | 2017 | World Journal of Gastroenterology2017，23，7： | 7 |
| 3 | Organisms causing spontaneous bacterial peritonitis in children with liver disease and ascites in Southern Iran显示文摘AIM: To determine the causative agents of spontaneous bacterial peritonitis (SBP) in children with liver disease and ascites in our center.METHODS: During a 2.5 year period, from September 2003 to March 2006, 12 patients with 13 episodes of SBP were studied. In all cases at the time of admission serum albumin and glucose, urinalysis and urine culture was performed. Analysis [white blood cell (WBC) count with differential, albumin, glucose], gram stain, culture by BACTEC method and antibiogram was done on ascitic fluids. Abdominal paracentesis was repeated after 48 h of antibiotic therapy for bacteriologic assay. The patients were followed for at least three months in a gastroenterology clinic. RESULTS: There were 7 girls (58%) and 5 boys (42%) with a median age of 5.2 years (range, 6 mo to 16 years). All cases had positive ascitic fluid culture. Gram stain was positive in 5 (38.5%) of them. The isolated organisms were S. pneumoniae in 5 (38.5%), E. coli in 2 (15.3%), S. viridans in 2 (15.3%), and K. pneumoniae, H. influenza, Enterococci, and nontypable Streptococcus each in one (7.7%). All of them except Enterococci were sensitive to ciprofloxacin and ceftriaxone. All ascitic fluid cultures were negative after 48 h of antibiotic therapy. CONCLUSION: S. pneumoniae is the most common cause of SBP in the pediatric age group and we recom-mend a third generation cephalosporine (e.g., Ceftriax-ione or Cefotaxime) for empirical therapy in children with SBP. | Mahmood Haghighat Seyed Mohsen Dehghani Abdolvahab Alborzi Mohammad Hadi Imanieh Bahman Pourabbas Mehdi Kalani | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 4 | Can Campylobacter jejuni play a role in development of celiac disease? A hypothesis显示文摘乳糜泻(CD ) 是有到谷物谷物蛋白质(面筋) 的变态反应在引起小肠粘膜损害的 malabsortive 状况的 entropathy。CD 是基因、环境的因素在贡献疾病开发的多因素的混乱。机制被描述了解释 CD 的病理。为多重面筋肽特定的 T 房间被发现在几乎所有病人。如此的宽广 T 房间回答的产生可以是为疾病开发的一个前提。CD 与多重额外的肠的演讲被联系,包括神经病学的赤字。最近的研究与内在的 CD 在病人显示出在 anti-ganglioside 抗体和神经病学的混乱之间的重要关联。Gangliosides 是充满神经系统并且在包括胃肠道的另外的纸巾的 glycosphingolipids。什么与面筋敏感在人触发 anti-ganglioside 抗体的版本,不被知道。但是,机制是可能的包含肠的免疫系统反应到摄取的麦胶蛋白质,小麦的一个部件面筋。研究证明与面筋暴露不同的机制可以在抗体形成被含有,并且另外的环境因素可以也存在。另外,考虑基因倾向 dysregulating 粘膜免疫者回答面对某些环境扳机喜欢胃肠的感染的事实可以是为开发长期的肠的发炎包括的强壮的病因学的因素 CD ,假设在腹的病人,而且在 CD 本身的开发不仅在神经病学的复杂并发症的开发在我们在 CD 的那 antiganglioside 抗体形成可以玩的头脑提起了一个角色。作为在有 antigangliosides 的另外的疾病的 Campylobacter jejuni 的存在,抗体形成被建立了,我们由对两 lipo-polysacharide 普通的象gangliosides一样 epitopes 的分子的模仿 Campylobacter jejuni 的某些紧张覆盖的机制与另外的基因、环境的因素联合在 CD 的开发建议 Campylobacter jejuni 的可能的角色,在胃肠的粘膜的房间结构的 gangliosides 可以引起自体免疫的回答并且因而带到粘膜的萎缩和退化可能由 apoptosis 。 | Behnam Sabayan Farzaneh Foroughinia Mohammad Hadi Imanieh | 2007 | World Journal of Gastroenterology2007，13，35： | 2 |
| 5 | Efficacy of the Standard Quadruple Therapy Versus Triple Therapies Containing Proton Pump Inhibitor Plus Amoxicillin and Clarithromycin or Amoxicillin-Clavulanic Acid and Metronidazole for Helicobacter pylori Eradication in Children显示文摘 | Seyed Mohsen Dehghani Asma Erjaee Mohammad Hadi Imanieh Mahmood Haghighat | 2009 | Digestive Diseases and Sciences2009，，8： | 1 |
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