|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vascular endothelial growth factor trap-eye(Aflibercept) for the management of diabetic macular edema显示文摘Diabetic retinopathy(DR)is the most common cause of visual loss among working age individuals.Diabetic macular edema(DME)is an important complication of DR that affects around one third of the patients with DR.Several treatments have been approved for DME ranging from blood pressure and glycemic control to photocoagulation and more recently the use of vascular endothelial growth factor(VEGF)antagonists.The index review discusses aflibercept(EYLEA-Regeneron Pharmaceuticals,Inc.,Tarrytown,New York,NY,and Bayer Healthcare Pharmaceuticals,Berlin,Germany)in the context of other VEGF antagonists currently available for the treatment of DME.A systematic search of literature was conducted on PubMed,Scopus,and Google Scholar with no limitation on language or year of publication.Pre-clinical studies of aflibercept have shown a higher affinity of this molecule for vascular endothelial growth factor A(VEGF-A)along with a longer duration of action as compared to other VEGF antagonists.Recent clinical trials have shown visual outcome results for aflibercept to be similarly favorable as compared to other available agents with the added benefit of fewer required injections and less frequent monitoring.Aflibercept presents a potential exciting new addition to the armamentarium of current VEGF antagonists available for the treatment of DME and other retinal vascular diseases.However,further studies are indicated to confirm the role,safety,and efficacy of aflibercept for DME. | Ahmadreza Moradi Yasir Jamal Sepah Mohammad Ali Sadiq Humzah Nasir Salima Kherani Raafay Sophie Diana V Do Quan Dong Nguyen | 2013 | World Journal of Diabetes2013，4，6： | 8 |
| 2 | Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic Review and Meta-Analysis显示文摘 | Patricia Jabre Véronique L. Roger Mohammad H. Murad Alanna M. Chamberlain Larry Prokop Frédéric Adnet Xavier Jouven | 2011 | Circulation2011，，15： | 2 |
| 3 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 4 | Performance analysis of bearing-only tracking algorithm 显示文摘 | DAVID V HUY S MOHAMMAD F | 2004 | Proceedings of SHE2004，3365，7： | 1 |
| 5 | Nepehinol-a new triterpene from Nepeta hindostana显示文摘 | Ahmad V U Bano S Mohammad F V | 1985 | Planta Med1985，，6： | 1 |
| 6 | Temporal bone disease:a comparison between high resolution computed tomography and pluridirectional tomography显示文摘 | Chat V Mohammad S Leon K | 1983 | Radiology1983，147，： | 1 |
| 7 | Influenza vaccination: an emerging opportunity to prevent cardio vascular disease显示文摘 | Mohammad M Silvio L Deborah V | 2004 | International Congress Series2004，126，3： | 1 |
| 8 | Vanadium increases GLUT4 in diabetic rat skeletal muscle显示文摘 | MOHAMMAD A SHARMA V MCNEILL J H | 2002 | Mol Cell Biochem2002，233，12： | 1 |
| 9 | Performance analysis of bearing only tracking algorithm显示文摘 | DAVID V HUY S MOHAMMAD F | 2004 | Proceedings of SPIE2004，3365，7： | 1 |
| 10 | Development of azithromycin-PLGA nanoparticles:Physicochemical characterization and antibacterial effect against Salmonella typhi显示文摘 | Ghobad M Hadi V Mohammad B J | 2010 | Colloid Surface B2010，80，： | 1 |
| 11 | Pyrrolizidine Alkaloids from Senecio Lorenthii显示文摘 | Noorwala M Mohammad F V Ahmad V U | 2000 | Fitoterapia2000，71，5： | 1 |
| 12 | Outpatient laparosco- pie adrenaleetomy: a Canadian experience 显示文摘 | Mohammad WM Frost I Moonje V | 2009 | Surg Lapa- rosc Endosc Pereutan Tech2009，，4： | 1 |
| 13 | Incidence of Upper Limb Venous Thronbosis Associated with Peripherally Inserted Central Catheters (PICC)显示文摘 | Abdullah B J Mohammad N Sangkar J V | 2005 | Br J Radiol2005，78，931： | 1 |
| 14 | Antidiabetic effects of quercetin in streptozotocin-induced diabetic rats显示文摘 | Mahmood V Mina H Mohammad V | 2003 | Comp Biochem Physiol P2003，135，3： | 1 |
| 15 | Effects of Fusion Zone Size and Failure Mode on Peak Load and Energy Absorption of Advanced High Strength Steel Spot Welds Under Lap Shear Loading Conditions 显示文摘 | Xin Sun Elizabeth V Stephens Mohammad A Khaleel | 2008 | Engineering Failure Analysis2008，15，： | 1 |
| 16 | Quantum dots:synthesis,bioapplications and toxicity显示文摘 | Alireza V Haleh M Mohammad S | 2012 | Nanosale Res Left2012，7，1： | 1 |
| 17 | Influenza vaccination:an emerging opportunity to prevent cardio vascular disease显示文摘 | Mohammad M Silvio L Deborah V | 2004 | International Congress Series2004，126，3： | 1 |
| 18 | Modeling TCP long file transfer latency over long delay wireless multilink PPP 显示文摘 | ZAGHLOUL S FROST V MOHAMMAD A J | 2005 | Communications Letters2005，9，11： | 1 |
| 19 | Sorption of arsenic,cadmium,and lead by chars produced from fast pyrolysis of wood and bark during bio-oil production显示文摘 | Mohan D Pittman C.U Bricka M Smith F Yancey B Mohammad J Steele P.H Alexandre-Franco M.F Gómez-Serrano V Gong H | | 0，，01： | 1 |
| 20 | Outpatient laparoscopic adrenalectomy:a Canadian experience显示文摘 | MOHAMMAD WM FROST I MOONJE V | 2009 | Surg Laparosc Endosc Percutan Tech2009，19，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员