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| 1 | Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment显示文摘Melanoma is the most aggressive form of skin cancer.Disrupted intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment. | Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell Mossaad Megahed | 2015 | World Journal of Experimental Medicine2015，5，4： | 15 |
| 2 | A pilot study of antioxidant potential of endophytic fungi from some Sudanese medicinal plants显示文摘Objective: To evaluate the total phenolic content and total antioxidant capacity of ethyl acetate extracts of 21 endophytic fungi isolated from five Sudanese medicinal plants: Calotropis procera, Catharanthus roseus, Euphorbia prostrate, Vernonia amygdalina and Trigonella foenumgraecum. Methods: Crude extracts of endophytic fungi and their host plants were tested by classical Folin-Ciocalteu colorimetric method to determine the total phenolic content, also total antioxidant capacity was estimated using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging in vitro method. Results: Among the endophytes, endophytic fungus Aspergillus sp. from Trigonella foenum-graecum seeds demonstrated the highest both total phenolic content in term of gallic acid equivalent(GAE) [(89.9±7.1 mg GAE/g)] and antioxidant activity for 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay [IC50:(18.0±0.1 μg/m L)]. A high positive linear correlation(R2=0.999 1) was found between total antioxidant capacity and total phenolic content of endophytic fungi isolated from Vernonia amygdalina. Conclusions: The present study revealed that some endophytic fungi from the five Sudanese medicinal plants could be a potential source of novel natural antioxidant compounds. | Afra Khiralla Ietidal Mohamed Justinne Thomas Beno t Mignard Rosella Spina Sakina Yagi Dominique Laurain-Mattar | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，9： | 9 |
| 3 | Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt显示文摘AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. | Nizar Saleh Abdelfattah Mohamed Amgad Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem | 2014 | International Journal of Ophthalmology(English edition)2014，7，5： | 8 |
| 4 | Nationwide trends and predictors of inpatient mortality in 83884 transjugular intrahepatic portosystemic shunt显示文摘AIM: To evaluate and validate the national trends and predictors of in-patient mortality of transjugular intrahepatic portosystemic shunt(TIPS) in 15 years.METHODS: Using the National Inpatient Sample which is a part of Health Cost and Utilization Project, we identified a discharge-weighted national estimate of 83884 TIPS procedures performed in the United States from 1998 to 2012 using international classification of diseases-9 procedural code 39.1. The demographic, hospital and co-morbility data were analyzed using a multivariant analysis. Using multi-nominal logistic regression analysis, we determined predictive factors related to increases in-hospital mortality. Comorbidity measures are in accordance to the Comorbidity Software designed by the Agency for Healthcare Research and Quality.RESULTS: Overall, 12.3% of patients died during hospitalization with downward trend in-hospitalmortality with the mean length of stay of 10.8 ± 13.1 d. Notable, African American patients(OR = 1.809 vs Caucasian patients, P < 0.001), transferred patients(OR = 1.347 vs non-transferred, P < 0.001), emergency admissions(OR = 3.032 vs elective cases, P < 0.001), patients in the Northeast region(OR = 1.449 vs West, P < 0.001) had significantly higher odds of inhospital mortality. Number of diagnoses and number of procedures showed positive correlations with in-hospital death(OR = 1.249 per one increase in number of procedures). Patients diagnosed with acute respiratory failure(OR = 8.246), acute kidney failure(OR = 4.359), hepatic encephalopathy(OR = 2.217) and esophageal variceal bleeding(OR = 2.187) were at considerably higher odds of in-hospital death compared with ascites(OR = 0.136, P < 0.001). Comorbidity measures with the highest odds of in-hospital death were fluid and electrolyte disorders(OR = 2.823), coagulopathy(OR = 2.016), and lymphoma(OR = 1.842).CONCLUSION: The overall mortality of the TIPS procedure is steadily decreasing, though the length of stay has remained relatively constant. Specific patient ethnicity, location, transfer status, primary diagnosis and comorbidities correlate with increased odds of TIPS in-hospital death. | Edward Wolfgang Lee Andrew Kuei Sammy Saab Ronald W Busuttil Francisco Durazo Steven-Huy Han Mohamed M El-Kabany Justin P Mc Williams Stephen T Kee | 2016 | World Journal of Gastroenterology2016，22，25： | 7 |
| 5 | A New Paradigm for Waste Classification Based on YOLOv5显示文摘Classification of garbage is of paramount importance prior to process them to categorise physically and this process helps to manage wastes by maintaining pollution free environment.Many systems that have capability segregate garbage are on the rise,but efficient and accurate segmentation with recognition mechanisms draw the attention of researchers.A computer vision approach for classifying garbage into respective recyclable categories could be one of the effective and economical ways of processing waste.This project mainly focused on capturing real-time images of a single piece of garbage and classifying it into three divisions:paper,or metal,or biodegradable(food)waste.Each garbage class contains around 2000 images obtained from an open-source dataset and images collected from Google and personally collected custom images.The developed intelligent models provide the effectiveness of the machine and deep learning in classification with structural and non-structural data.The model used was a Convolutional Neural Network(CNN)named YOLOv5.The project showcased vision based approach capable of maintaining an accuracy of 61%.The CNN was not trained to its maximum capacity due to the difficulty of finding optimal hyperparameters,as most of the images were gathered from Google Images. | Mohammed SAJID Nimali T MEDAGEDARA | 2021 | Instrumentation2021，8，4： | 3 |
| 6 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 7 | 浸渍硅胶薄层色谱板分离钴和镍及数字图像分析法定量(英文)显示文摘Thin layer chromatography(TLC) of cobalt and nickel has been performed on silica gel layers induced with alkali mediated cellulose extract.A novel combination of 10% aqueous solutions of Tween-20 and potassium thiocyanate in 1∶1(v/v) was identified as the best mobile phase for the selective separation of Co2+from Ni2+on the impregnated Silica Gel G layers.The chromatographic characteristics of the cations were studied and the limits of detection as well as the limits of quantification for Co2+and Ni2+were determined.The quantitative estimation of the cations was achieved from the digital image analysis of respective chromatograms.The proposed quantitative method was successfully applied with 0-0.50% error for the determination of Co2+from Ni2+in spiked samples of bauxite,soil and rock containing common cations such as Al3+,Fe2+,Ti4+,Zn2+,Mn2+,Cu2+,Cr6+,Mg2+,etc.under the optimized chromatographic conditions. | P A MOHAMED NAJAR R G SONALI M T NIMJE K V RAMANA RAO | 2012 | 色谱2012，30，10： | 2 |
| 8 | Novel method for preparation of β-cyclodextrin/grafted chitosan and it's application 显示文摘 | KHALED E T MOHAMED A G SAFAA E R | 2006 | Carbohydrate Polymers2006，63，3： | 1 |
| 9 | Extrapelvic endometriosis presenting as unusual swellings of the buttick and thigh显示文摘 | Ali T Mohammed F Hoford R | 2001 | West Indian Med J2001，50，： | 1 |
| 10 | The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death 显示文摘 | Mohammed T Anna MC Keliu | 2003 | J Biol Chem2003，278，19： | 1 |
| 11 | Solute transport through unsaturat- ed soil due to evaporation 显示文摘 | Mohamed A A Sasaki T Watanabe K | 2000 | Journal of Environmental Engineering2000，126，9： | 1 |
| 12 | Physicochemical characteristics of soy protein isolate and fenugreek gum dispersed systems 显示文摘 | HEFNAWY T M H MOHAMED F R | 2011 | Jonmal of Food Science and Technology2011，48，3： | 1 |
| 13 | Effects of Sur- face Treatments on Photoelectric Work Function of Sil- ver-nickel Alloys显示文摘 | Mohamed A Aissa B Mahdjoub F T | 2014 | Vacuum2014，101，： | 1 |
| 14 | Reamed intramedullary nailingversus undreamed intramedullary nailing for shaft fracture of fe-mur: a systematic literature review 显示文摘 | Duan X Li T Mohammed AQ | 2011 | Arch Orlhop Trauma Surg2011，131，： | 1 |
| 15 | Does vitamin D have protective effect on human nasal polyposis:histological and immunohistochemical study显示文摘 | Faruk EM Yousef MM Mohamed T | 2014 | J Histol Histopathol2014，1，： | 1 |
| 16 | Human infective endocarditis caused by Streptococcus suis serotype 2显示文摘 | Mohamed W Hain T | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 17 | Chloride diffusion,microstructure,and mineralogy of concrete after 15 years of exposure in tidal environment显示文摘 | Mohammed TU Yamanji T Hamada H | 2002 | ACI Materials Journal2002，1999，3： | 1 |
| 18 | Environmental impact and management of phosphogypsum 显示文摘 | Hanan T Mohamed C Felix A L | 2009 | Journal of Environmental Man- agement2009，90，8： | 1 |
| 19 | Natural hazard assess- ment using G1S and remote sensing methods,with particular refer- ence to the landslides in the Wondogenet area, Ethipia 显示文摘 | Temesgen B Mohammed M U Korme T | 2001 | Physics and Chemistry of the Earth Part C : Solar Terrestrial & Planetary Science2001，26，9： | 1 |
| 20 | Headache, migraine, and structural brain lesions and function:population based epidemiology of vascular ageing-MR/study显示文摘 | Kurth T Mohamed S Maillard P | 2011 | BMJ2011，18，342： | 1 |
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