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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Synthesis, characterization and effect of reaction parameters on swelling properties of acrylamide-sodium methacrylate superabsorbent copolymers 显示文摘 | Mohan Y M Murthy P S K Raju K M | 2005 | Reactive & Functional Polymers2005，63，： | 1 |
| 3 | Lupus nephritis:treatment of resistant disease显示文摘 | Kalloo S Aggarwal N Mohan P | 2013 | Clin J Am Soc Nephrol2013，8，1： | 1 |
| 4 | Preparation and swelling behavior of macroporous poly (acrylamide-co-sodium methacrylate) superabsorbent hydrogels显示文摘 | Mohan Y M Murthy P S K Raju K M | 2006 | Journal of Applied Polymer Science2006，101，5： | 1 |
| 5 | Semi-IPNs of starch and poly (aerylamide-eo-sodium methacrylate) : Preparation, swelling and diffusion characteristics evaluation 显示文摘 | Keshava Murthy P S Murali Mohan Y Sreeramulu J | 2006 | Reactive & Functional Polymers2006，66，： | 1 |
| 6 | Design and fabrication of an automated technique: measurement of spontaneous polarization in two new schiff'base ferroelectric liquid crystals 显示文摘 | Madhu Mohan M L N Goud B V S Kumar P A | 1999 | Materials Research Bulletin1999，34，1415： | 1 |
| 7 | Com-pact multiple-valued multiplexers using negative differen-tial resistance devices 显示文摘 | CHAN H L MOHAN S MAZUMDER P | 1996 | IEEE Journal of Sold-StateCircuits1996，31，8： | 1 |
| 8 | A two - photon fluorescent probe for near - membrane calcium ions in live ceils and tissues 显示文摘 | Mohan P S Lim C S Tian Y S | 2009 | Chem Commun2009，，36： | 1 |
| 9 | Studies on corrosion resistant properties of inhibitive primed IPN coating systems incomparison with epoxy-PU systems 显示文摘 | Krishnan S M Mohan P S | 2007 | Journal of Coat- ings Technology and Research2007，4，1： | 1 |
| 10 | Development of dense gas dispersion model for emergency preparedness 显示文摘 | Mohan M Panwar T S Singh M P | 1995 | Atmospheric Environment1995，29，16： | 1 |
| 11 | Development of dense gas diserpersion model for emergency preparedness显示文摘 | MOHAN Panwar T S Singh M P | 1995 | Atmospheric Environment1995，29，16： | 1 |
| 12 | RBBB, ECG Rv strain, and abnormal car- diac biomarkers in diagnosis of right ventricular dysfunction and outcomes in critically ill patients显示文摘 | Rajan S Mohan L Mehul P | 2011 | Am J Respir Crit Care Med2011，183，： | 1 |
| 13 | Compar- ative bioelectrochemical analysis of pseudornonas aeruginosa and Escherichia coli with anaerobic consortia as anodic biocatalyst for biofuel cell appli- cation 显示文摘 | Raghavulu S V Sarma P N Mohan S V | | J Appl Microbiol0，110，3： | 1 |
| 14 | Physical properties of LiMn2O4 spinel prepared at moderate temperature显示文摘 | CHITRA S KALYANI P MOHAN T | 1998 | Ionics1998，4，12： | 1 |
| 15 | Adsorption removal of fluoride from aqueous phase using waste fungus ( Pleurotus ostreatus 1804) biosorbent: kinetics evaluation显示文摘 | RAMANAIAH S V MOHAN S V SARMA P N | 2007 | Ecological Engineering2007，31，1： | 1 |
| 16 | Prediction of irrigation return flows through a hierarchical modeling approach显示文摘 | Mohan S Vijayalakshmi D P | 2009 | Agricultural Water Management2009，96，2： | 1 |
| 17 | Bioslurry phase degradation of di-ethyl phthalate (DEP) contaminated soil in periodic discontinuous mode operation: Influence of bioaugmentation and substrate partition 显示文摘 | MOHAN SV SHAILAJA S KRISHNA MR REDDY KB SARMA P N | 2006 | Process Biochemistry2006，41，3： | 1 |
| 18 | Canteen based composite foodwaste as potential anodic fuel for bioelectricity generation in single chambered microbial fuel cell (MFC): Bio- electro chemical evaluation under increasing substrate loading condition 显示文摘 | Goud R K Babu P S Mohan S V | 2011 | International Journal of Hydrogen Energy2011，36，： | 1 |
| 19 | Prevalence of job strain among Indian foundry shop floor workers显示文摘 | MOHAN G M ELANGOVAN S KRISHNA P R | 2008 | IOS Press2008，30，4： | 1 |
| 20 | A retroperitoneal bleed induced by enoxaparin therapy显示文摘 | ERNITS M MOHAN P S FARES L G | 2005 | Am Surg2005，71，5： | 1 |
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