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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Small molecule modulators of histone acetylation and methylation: A disease perspective显示文摘 | B. Ruthrotha Selvi D.V. Mohankrishna Yogesh B. Ostwal Tapas K. Kundu | 2010 | BBA - Gene Regulatory Mechanisms2010，，： | 1 |
| 3 | Small molecule mod- ulators ofhistone acetylation and methylatior~ a disease perspective 显示文摘 | Selvi BR Mohankrishna DV Ostwal YB | 2010 | Biochim Biophys Acta2010，1799，1012： | 1 |
| 4 | Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population显示文摘 | G. R. Chandak C. S. Janipalli S. Bhaskar S. R. Kulkarni P. Mohankrishna A. T. Hattersley T. M. Frayling C. S. Yajnik | 2007 | Diabetologia2007，，1： | 1 |
| 5 | Small molecule modulators of histone acetylation and methylation: A disease per- spective 显示文摘 | Selvi BR Mohankrishna DV Ostwal YB | 2010 | Biochim Biophys Acta2010，1799，101112： | 1 |
| 6 | Comprehensive Overview and Analytical Study on Automatic Bird Repellent Laser System for Crop Protection显示文摘Birds are a huge hazard to agriculture all around the world,causing harm to profitable field crops.Growers use a variety of techniques to keep them away,including visual,auditory,tactile,and olfactory deterrents. This study presents a comprehensive overview of current bird repellant approaches used in agricultural contexts,as well as potential new ways. The bird repellent techniques include Internet of Things technology,Deep Learning,Convolutional Neural Network,Unmanned Aerial Vehicles,Wireless Sensor Networks and Laser biotechnology. This study’s goal is to find and review about previous approach towards repellent of birds in the crop fields using various technologies. | Sireesha Abotula Srinivas Gorla Prasad Reddy PVGD Mohankrishna S | 2024 | Journal of Harbin Institute of Technology(New Series)2024，31，1： | 0 |
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