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| 1 | Glutathione depleting drugs, antioxidants and intestinal calcium absorption显示文摘Glutathione(GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them. | Luciana Moine María Rivoira Gabriela Díaz de Barboza Adriana Pérez Nori Tolosa de Talamoni | 2018 | World Journal of Gastroenterology2018，24，44： | 5 |
| 2 | Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: Effects on right ventricular function显示文摘 | P Van der Linden O Le Moine M Ghysels M Ortinez J Deviere | 1996 | Hepatology1996，，5： | 2 |
| 3 | A further study of numerical errors in large-eddy simulations显示文摘 | Chow F K Moin P | 2003 | Journal of Computational Physics2003，184，2： | 1 |
| 4 | Direct simulations of turbulent flow using finite difference schemes显示文摘 | Moin P | 1991 | Sei Comput1991，，1： | 1 |
| 5 | Numerical Investigation of Turbulent Channel Flow显示文摘 | Moin P Kim J | 1982 | Journal of Fluid Mechanics1982，118，： | 1 |
| 6 | Active control of flow separation over an airfoil using synthetic jets显示文摘 | You D Moin P | 2008 | J Fluid Struct2008，24，8： | 1 |
| 7 | Progress in large eddy simulation of turbulence flows显示文摘 | Moin P | 1997 | AIAA Journal1997，38，2： | 1 |
| 8 | Active control of flow separation over an airfoil using synthetic jets 显示文摘 | You D Moin P | 2008 | Journal of Fluids and Structures2008，24，8： | 1 |
| 9 | NF - kappa B regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome 显示文摘 | Moine P Mclntyre R Schwartz MD | 2000 | Shock2000，13，2： | 1 |
| 10 | Progress-variable approach for large-eddy simulation of non-premixed turbulent combustion显示文摘 | Pierce C D Moin P | 2004 | Journal of Fluid Mechanics2004，504，： | 1 |
| 11 | On the relation of near-wall streamwise vortices to wall skin friction in turbulent boundary layers 显示文摘 | Kravchenko A G Choi H Moin P | 1993 | Phys Fluids1993，5，12： | 1 |
| 12 | Direct numerical simulation: a tool in turbulence research 显示文摘 | Moin P Mahesh K | 1998 | Annual Review of Fluid Mechanics1998，30，： | 1 |
| 13 | Mortalityassociatedwithla-teonsetpneumoniaintheintensivecareunit: Resultsofamulticenterco-hortstudy 显示文摘 | Moine P Timsit JF DeLassence A | 2002 | Intensive Care Med2002，28，： | 1 |
| 14 | A dynamic global-coefficient subgrid- scale eddyviscosity model for large-eddy simulation in complex geometries 显示文摘 | You D Moin P | 2007 | Physics of Fluids2007，19，06： | 1 |
| 15 | Application of fractional-step method to incompressible Navier-Stokes equations显示文摘 | KIM J MOIN P | 1985 | Journal of Computational Physics1985，59，2： | 1 |
| 16 | Active control of flow separation over an airfoil using synthetic jets显示文摘 | You D Moin P | 2008 | Journal of Fluids and Structures2008，24，8： | 1 |
| 17 | A dynamic subgridscale eddy viscosity model显示文摘 | Germano M Piomelli U Moin P | 1991 | Physics of Fluids1991，3，7： | 1 |
| 18 | A dynamic global-coefficient subgrid- scale model for large-eddy simulation of turbulent scalar transport in complex geometries显示文摘 | You D Moin P | 2009 | Physics of Fluids2009，21，04： | 1 |
| 19 | A Dynamic Subgrid-Scale Eddy Viscosity Model显示文摘 | Germano M Piomelli U Moin P | 1991 | Phys Fluids1991，3，7： | 1 |
| 20 | Advances in large eddy simulation methodology for complex flows 显示文摘 | Moin P | 2002 | International Journal of Heat and Fluid Flow2002，24，5： | 1 |
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