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14篇 您的检索式：作者名="Mok TC"

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		题名	作者	年代	出处	被引量
	1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
	2	Retrospective comparison of management of gastro-enteritis in hospitalised children 显示文摘	Nelson EA Mok TC u LM	2002	Ann Trop Pediatrcs2002，22，2：	1
	3	Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnosfic serum total alpha-fetoprotein 显示文摘	Poon TC Mok TS Chart AT	2002	Clin Chem2002，48，7：	1
	4	Seasonal influenza activity in Hong Kong and its association with meteorological variations 显示文摘	Chan PK Mok HY Lee TC	2009	J Med Virol2009，81，10：	1
	5	Rotavirus activity and meteorological variations in an Asian subtropical city, Hong Kong, 1995-2009显示文摘	Chan MC Mok HY Lee TC	2013	J Med Virol2013，85，11：	1
	6	Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnostic serum total alpha-fetoprotein 显示文摘	Poon TC Mok TS Chan AT	2002	Clin Chem2002，48，7：	1
	7	Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes显示文摘	Poon TC Yip TT Chan AT Yip C Yip V Mok TS	2003	Clin Chem2003，49，5：	1
	8	Attenuation correction of PET images with interpolated average CT for thoracic tumors显示文摘	Huang TC Mok GS Wang SJ	2011	Phys Med Biol2011，56，8：	1
	9	Rotavirus activity and meteorological variations in an Asian subtropical city, Hong Kong, 1995-2009 显示文摘	Chan MC Mok HY Lee TC	2013	J Med Virol2013，85，11：	1
	10	Efficacy of bevacizumab with cisplatin and gemcitabine in Asian patients with ad-vanced or recurrent non-squamous non-small cell lung cancer who have not received prior chemotherapy:a substudy of the Avastin in lung trial显示文摘	Mok TS Hsia TC Tsai CM	2011	Asia Pac J Clin Oncol2011，7，2：	1
	11	Behcet's disease in southern Chinese patients显示文摘	Mok CC Cheng TC Ho CT	2002	J Rheumatol2002，29，：	1
	12	Behcet's disease in south-ern Chinese patients 显示文摘	Mok CC Cheng TC Ho CT	2002	J Rheumatol2002，29，：	1
	13	Seasonal influenza activity in Hnng Kong and its association wi!h meteorological variations 显示文摘	Chan PK Mok HY Lee TC	2009	J Med Virol2009，81，10：	1
	14	Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiag- nostic serum total alpha-fetoprotein显示文摘	Pooh TC Mok TS Chan AT	2002	Clin Chem2002，48，7：	1

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