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| 1 | Study of Helicobacter pylori genotype status in saliva,dental plaques,stool and gastric biopsy samples显示文摘AIM:To compare genotype of Helicobacter pylori(H.pylori) isolated from saliva,dental plaques,gastric biopsy,and stool of each patient in order to evaluate the mode of transmission of H.pylori infection.METHODS:This cross-sectional descriptive study was performed on 300 antral gastric biopsy,saliva,dental plaque and stool samples which were obtained from patients undergoing upper gastrointestinal tract endoscopy referred to endoscopy centre of Hajar hospital of Shahrekord,Iran from March 2010 to February 2011.Initially,H.pylori strains were identified by rapid urease test(RUT) and polymerase chain reaction(PCR) were applied to determine the presence of H.pylori(ureC) and for genotyping of voculating cytotoxin gene A(vacA) and cytotoxin associated gene A(cagA) genesin each specimen.Finally the data were analyzed by using statistical formulas such as Chi-square and Fisher's exact tests to find any significant relationship between these genes and patient's diseases.P < 0.05 was considered statistically significant,RESULTS:Of 300 gastric biopsy samples,77.66% were confirmed to be H.pylori positive by PCR assay while this bacterium were detected in 10.72% of saliva,71.67% of stool samples.We were not able to find it in dental plaque specimens.The prevalence of H.pylori was 90.47% among patients with peptic ulcer disease(PUD),80% among patients with gastric cancer,and 74.13% among patients with none ulcer dyspepsia(NUD) by PCR assay.The evaluation of vacA and cagA genes showed 6 differences between gastric biopsy and saliva specimens and 11 differences between gastric and stool specimens.94.42% of H.pylori positive specimens were cagA positive and all samples had amplified band both for vacA s and m regions.There was significant relationship between vacA s1a/m1a and PUD diseases(P = 0.04),s2/m2 genotype and NUD diseases(P = 0.05).No statically significant relationship was found between cagA status with clinical outcomes and vacA genotypes(P = 0.65).The evaluation of vacA and cagA genes showed 6 differences between gastric biopsy and saliva specimens and 11 differences between gastric and stool specimens,CONCLUSION:Regard to high similarity in genotype of H.pylori isolates from saliva,stomach and stool,this study support the idea which fecal-oral is the main route of H.pylori transmission and oral cavity may serve as a reservoir for H.pylori,however,remarkable genotype diversity among stomach,saliva and stool samples showed that more than one H.pylori genotype may exist in a same patient. | Hassan Momtaz Negar Souod Hossein Dabiri Meysam Sarshar | 2012 | World Journal of Gastroenterology2012，18，17： | 21 |
| 2 | Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways显示文摘Inflammatory bowel disease(IBD)refers to a group of disorders characterized by chronic inflammation of the gastrointestinal(GI)tract.The elevated levels of nitric oxide(NO)in serum and affected tissues;mainly synthesized by the inducible nitric oxide synthase(iNOS)enzyme;can exacerbate GI inflammation and is one of the major biomarkers of GI inflammation.Various natural and synthetic agents are able to ameliorate GI inflammation and decrease iNOS expression to the extent comparable with some IBD drugs.Thereby,the purpose of this study was to gather a list of natural or synthetic mediators capable of modulating IBD through the NO pathway.Electronic databases including Google Scholar and PubMed were searched from 1980 to May 2018.We found that polyphenols and particularly flavonoids are able to markedly attenuate NO production and iNOS expression through the nuclear factorκB(NF-κB)and JAK/STAT signaling pathways.Prebiotics and probiotics can also alter the GI microbiota and reduce NO expression in IBD models through a broad array of mechanisms.A number of synthetic molecules have been found to suppress NO expression either dependent on the NF-κB signaling pathway(i.e.,dexamethasone,pioglitazone,tropisetron)or independent from this pathway(i.e.,nicotine,prednisolone,celecoxib,β-adrenoceptor antagonists).Co-administration of natural and synthetic agents can affect the tissue level of NO and may improve IBD symptoms mainly by modulating the Toll like receptor-4 and NF-κB signaling pathways. | Aida Kamalian Masoud Sohrabi Asl Mahsa Dolatshahi Khashayar Afshari Shiva Shamshiri Nazanin Momeni Roudsari Saeideh Momtaz Roja Rahimi Mohammad Abdollahi Amir Hossein Abdolghaffari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | Hepatic veno-occlusive disease:pathogenesis,diagnosis and treatment显示文摘 | Wadleigh M Ho V Momtaz P | 2003 | Curr Opin Hematol2003，10，6： | 1 |
| 4 | Intrapartum prediction of macrosomia;accuracy of abdominal circumference estimation显示文摘 | Alaa N Momtaz M | 2001 | Gynecol Obstet Invest2001，51，2： | 1 |
| 5 | Unmet needs among disabled elderly Malaysians显示文摘 | Momtaz YA Hamid TA Ibrahim R | 2012 | Soc Sci Med2012，75，5： | 1 |
| 6 | Up-regulation of Endothelin-1 and Endothelin type A receptor genes expression in the heart of broiler chickens versus layer chickens显示文摘 | Hossein Hassanpour Masood Teshfam Hassan Momtaz Gholamreza Nikbakht Brujeni Lohrasb Shahgholian | 2010 | Research in Veterinary Science2010，，3： | 1 |
| 7 | Environmental impact assessment in Bangladesh:a critical review显示文摘 | | 2002 | Environ Impact Asses Rev2002，22，2： | 1 |
| 8 | The determinants of birth interval in Ahvaz-Iran: a graphical chain modeling approach 显示文摘 | ABDOLRAHMAN RASEKH MAJID MOMTAZ | 2007 | The Journal of Data Sciences2007，5，4： | 1 |
| 9 | Immunologic checkpoints in cancer therapy:Focus on the programmed death-1 (PD-1) receptor pathway 显示文摘 | MOMTAZ P POSTOW M A | 2014 | Pharmgenomics Pers Med2014，15，7： | 1 |
| 10 | Reactive angioendotheliomatosis with underlying hepatopathy and hypertensive portal gastropathy显示文摘 | Quinn TR Alora MB Momtaz KT | 1998 | Int J Dermatol1998，37，5： | 1 |
| 11 | A Survey on Prevalence and Pathological Findings of Gallstones in Lori-Bakhtiari Sheep in Iran显示文摘 | Raoofi A Rahmani Shahraki A Namjoo A Momtaz H | | 0，，： | 1 |
| 12 | 13-14-week fetal anatomyscan:a 5-year prospective study显示文摘 | Ebrashy A El Kateb A Momtaz M | | 0，，03： | 1 |
| 13 | Occurrence of virulence factors and antimicrobial resistance in Pasteurella multocida strains isolated from slaughter cattle in Iran显示文摘 | KHAMESIPOUR F MOMTAZ H ZHDARY MAMOREH M | 2014 | Front Microbiol2014，5，： | 1 |
| 14 | Hepatic veno-occlusive disease: pathogenesis, diagnosis andtreatment显示文摘 | Wadleigh M Ho V Momtaz P | 2003 | Curr ()pin Hematol2003，10，6： | 1 |
| 15 | Intrapartum prediction of macrosomia :accuracy of abdominal circumference estimation显示文摘 | Al-nany H Alaa N Momtaz M | 2000 | Gynecol Obstet Invest2000，51，2： | 1 |
| 16 | Identification of SA-MCFV DNA in blood,lymph node, and spleen of adult sheep,healthy cattle,and MCF cattle by PCR 显示文摘 | Kojouri G A Mahmoodi P Momtaz H | 2009 | Comparative Clinical Pathology2009，18，2： | 1 |
| 17 | Bacillus cereus in infant foods:prevalence study and distribution of enterotoxigenic virulence factors in Isfahan Province, Iran 显示文摘 | Rahimi E Abdos F Momtaz H | 2013 | The Scientific World Journal2013，，29： | 1 |
| 18 | Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment 显示文摘 | Wadleigh M Ho V Momtaz P | 2003 | Curr ()pin Hematol2003，10，6： | 1 |
| 19 | Three-dimensionalultrasonography in the evaluation of the uterine cavity显示文摘 | Mohamed M Momtaz MD Alaa N | | 0，，01： | 1 |
| 20 | An assessment of the variation in soil properties within and between landform in the Amol region, Iran 显示文摘 | Momtaz H R Jafarzadeh A A Torabi H | 2009 | Geoderma2009，102，1： | 1 |
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