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| 1 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 2 | Inflammatory bowel disease: An increased risk factor for neurologic complications显示文摘Only a very few systematic studies have investigated the frequency of neurologic disorders in patients with Crohn's disease(CD) and ulcerative colitis(UC), which are the two main types of inflammatory bowel disease(IBD). Results have been inconsistent and variable, owing to differences in case-finding methods and evaluated outcomes in different studies. The most frequent neurologic manifestations reported in CD and UC populations are cerebrovascular disease(with either arterial or venous events), demyelinating central nervous system disease, and peripheral neuropathy(whether axonal or demyelinating); however, the literature describes numerous nervous system disorders as being associated with IBD. The pathogenesis of nervous system tissue involvement in IBD has yet to be elucidated, although it seems to be related to immune mechanisms or prothrombotic states. The recently-introduced tumor necrosis factor(TNF) inhibitors have proven successful in controlling moderate to severe IBD activity. However, severe neurologic disorders associated with TNF inhibitors have been reported, which therefore raises concerns regarding the effect of anti-TNF-α antibodies on the nervous system. Although neurological involvement associated with IBD is rarely reported, gastroenterologists should be aware of the neurologic manifestations of IBD in order to provide early treatment, which is crucial for preventing major neurologic morbidity. | Germán Morís | 2014 | World Journal of Gastroenterology2014，20，5： | 3 |
| 3 | Adalimumab induction and maintenance therapy for patients with ulcerative colitis previously treated with infliximab显示文摘 | C.Taxonera J.Estellés I.Fernández‐Blanco O.Merino I.Marín‐Jiménez M.Barreiro‐de Acosta C.Saro V.García‐Sánchez E.Gento G.Bastida J. P.Gisbert I.Vera P.Martinez‐Montiel S.Garcia‐Morán M. C.Sánchez J. L.Mendoza | 2011 | Alimentary Pharmacology & Therapeutics2011，，3： | 2 |
| 4 | Prediagnostic symptom recognition and help seeking among cancer patients 显示文摘 | Mor V Masterson - Allen S Goldberg R | 1990 | J Community Health1990，15，4： | 1 |
| 5 | Role of the Fas/Fas ligand system in female reproductive organs:survival and apoptosis显示文摘 | Mor G Straszewski S Kamsteeg M | 2002 | Biochem Pharmacol2002，64，9： | 1 |
| 6 | Expression of recombination human acetylcholinesterase in transgenic tomato plants显示文摘 | Mor T S Sternfeld M Soreq H | 2001 | Biotech nolBioeng2001，75，3： | 1 |
| 7 | Amino acid-based surfactants显示文摘 | María Rosa Infante Lourdes Pérez Aurora Pinazo Pere Clapés María Carmen Morán Marta Angelet María Teresa García María Pilar Vinardell | 2004 | Comptes rendus - Chimie2004，，6： | 1 |
| 8 | Enzyme frome xtremophiles显示文摘 | David C Demirjian Francisco Mor s-Varas Constance S Cassidy | 2001 | Biocatalysis and Biotranformation2001，6，： | 1 |
| 9 | Induction of 3beta -hydrex- ystereid dehydregenase/deha5 -delta4 isomerase type 1 gene tran- serlption in human breast cancer cell lines and in normal mammary epithelial cells by interleukin -4 and interleukln - 13 显示文摘 | Gingras S Mor/ggl R Groner B et 8 1 | 1999 | Mol En- docrinol1999，13，1： | 1 |
| 10 | Proteome profile changes during mouse testis development显示文摘 | María Paz Matías Morín Jesús del Mazo | 2006 | Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics2006，，4： | 1 |
| 11 | Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine 显示文摘 | Mason H S Warzecha H Mor T | 2002 | Trends Mol Med2002，8，7： | 1 |
| 12 | The fibrolast - like synovial cell in rheumatoid arthritis: a key player in inflamma- tion and joint destruction 显示文摘 | MOR A ABRAMSON S B PILLINGER M H | 2005 | Clin Inamunol2005，115，2： | 1 |
| 13 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 14 | Leachate characterization and assessment of groundwater pollution near municipal solid waste landfill site 显示文摘 | Mor S Ravindra K Dahiya R P | 2006 | Environmcntal Monitoring & Assessment2006，118，13： | 1 |
| 15 | Starch and protein quality requirements of Japanese alkaline noodle显示文摘 | CROSBIE G B ROSS A S MORS T | 1999 | Cereal Chemistry1999，76，3： | 1 |
| 16 | Expression of MMP-9and TIMP-1 as prognostic markers in gastric carcinoma显示文摘 | de Mingo M Morán A Sánchez-Pernaute A | 2007 | Hepatogas-troenterology2007，54，73： | 1 |
| 17 | Role of the Fas/Fas ligand system in female reproductive organs:Survival and apoptosis显示文摘 | Mor G Straszewski S Kamsteeg M | | 0，，： | 1 |
| 18 | Starch and protein quality requirements of Japanese alkaline noodle 显示文摘 | Crosbie G B Ross A S Mors T | 1999 | Cereal Chem1999，76，3： | 1 |
| 19 | Testing unconstrained optimization software显示文摘 | Morè J J Garbow B S Hillstrome K E | 1981 | ACM Trans Math Software1981，7，： | 1 |
| 20 | Gefitinib or carboplatinpac-litaxel in pulmonary adenocarcinoma显示文摘 | Mor TS Wu YL Thongprasert S | 2009 | N Engl J Med2009，361，10： | 1 |
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