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| 1 | Hemoconcentration is a poor predictor of severity in acute pancreatitis显示文摘AIM: To determine whether the hematocrit (Hct) at admission or at 24 h after admission was associated with severe acute pancreatitis (AP), organ failure (OF), and pancreatic necrosis.METHODS: A total of 336 consecutive patients with a first AP episode were studied. Etiology, Hct values at admission and at 24 h, development of severe AP according to Atlanta's criteria, pancreatic necrosis, OF and mortality were recorded. Hemoconcentration was defined as Hct level >44% for males and >40% for females. The t-test and χ2 test were used to assess the association of hemoconcentration to the severity, necrosis and OF.Diagnostic accuracy was also determined.RESULTS: Biliary disease was the most frequent etiology(n = 148). Mean Hct levels at admission were 41±6%for females and 46±7% for males (P<0.01). Seventyeight (23%) patients had severe AP, and OF developed in 45 (13%) patients. According to contrast-enhanced computed tomography scan, 36% (54/150) patients showed pancreatic necrosis. Hct levels were elevated in58% (55/96) and 61% (33/54) patients with interstitial and necrotizing pancreatitis, respectively. Neither Hct levels at admission nor hemoconcentration at 24 h were associated with the severity, necrosis or OF. Sensitivity,specificity and positive predictive values for both determinations were very low; and negative predictive values were between 61% and 86%, being the highest value for OF.CONCLUSION: Hct is not a useful marker to predict a worse outcome in acute pancreatitis. In spite of the high negative predictive value of hemoconcentration, the prognosis gain is limited due to an already high incidence of mild disease. | José M.Remes-Troche Andrés Duarte-Rojo Gustavo Morales Guillermo Robles-Díaz | 2005 | World Journal of Gastroenterology2005，11，44： | 16 |
| 2 | Digoxin:A systematic review in atrial fibrillation,congestive heart failure and post myocardial infarction显示文摘AIM: To review digoxin use in systolic congestive heart failure, atrial fibrillation, and after myocardial infarction. METHODS: A comprehensive Pub Med search was performed using the key words 'digoxin and congestive heart failure', 'digoxin and atrial fibrillation', 'digoxin, atrial fibrillation and systolic congestive heart failure', and 'digoxin and myocardial infarction'. Only articles written in English were included in this study. We retained studies originating from randomized controlled trials, registries and included at least 500 patients. The studies included patients with atrial fibrillation or heart failure or myocardial infarction and had a significant proportion of patients(at least 5%) on digoxin. A table reviewing the different hazard ratios was developed based on the articles selected. Our primary endpoint was the overall mortality in the patients on digoxin vs those without digoxin, among patients with atrial fibrillation and also among patients with atrial fibrillation and systolic heart failure. We reviewed the most recent international guidelines to discuss current recommendations.RESULTS: A total of 18 studies were found that evaluated digoxin and overall mortality in different clinical settings including systolic congestive heart failure and normal sinus rhythm(n = 5), atrial fibrillation with and without systolic congestive heart failure(n = 9), and myocardial infarction(n = 4). Overall, patients with systolic congestive heart failure with normal sinus rhythm, digoxin appears to have a neutral effect on mortality especially if close digoxin level monitoring is employed. However, most of the observational studies evaluating digoxin use in atrial fibrillation without systolic congestive heart failure showed an increase in overall mortality when taking digoxin. In the studies evaluated in this systematic review, the data among patients with atrial fibrillation and systolic congestive heart failure, as well as post myocardial infarction were more controversial. The extent to which discrepancies among studies are based on statistical methods is currently unclear, as these studies' findings are generated by retrospective analyses that employed different techniques to address confounding. CONCLUSION: Based on the potential risks and benefits, as well as the presence of alternative drugs, there is a limited role for digoxin in the management of patients with normal sinus rhythm and congestive heart failure. Based on the retrospective studies reviewed there is a growing volume of data showing increased mortality in those with only atrial fibrillation. The pro-per role of digoxin is, however, less certain in other subgroups of patients, such as those with both atrial fibrillation and systolic congestive heart failure or after a myocardial infarction. Further studies may provide helpful information for such subgroups of patients. | Sebastiano Virgadamo Richard Charnigo Yousef Darrat Gustavo Morales Claude S Elayi | 2015 | World Journal of Cardiology2015，7，11： | 4 |
| 3 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 4 | Peptidomic analysis of whey protein hydrolysates and prediction of their antioxidant peptides显示文摘Enzymatic hydrolysis of proteins is a breakdown process of peptide bond in proteins,releasing some peptides with potential biological functions.Previous studies on enzymatic hydrolysis of whey proteins have not identified the complete peptide profiles after hydrolysis.In this study,we reconstructed a profile of peptides from whey hydrolysates with two enzymes and different processing conditions.We also developed an ensemble machine learning predictor to classify peptides obtained from whey hydrolysis.A total of 2572 peptides were identified over three process conditions with two enzymes in duplicate.499 peptides were classified and chosen as potential antioxidant peptides from whey proteins.The peptides classified as antioxidants in the hydrolysates had a proportion of 13.1%-24.5%regarding all peptides identified.These results facilitate the selection of promising peptides involved in the antioxidant properties during the enzymatic hydrolysis of whey proteins,aiding the discovery of novel antioxidant peptides. | Jesus Morales García Chibuike C.Udenigwe Jorge Duitama Andrés Fernando González Barrios | 2022 | Food Science and Human Wellness2022，11，2： | 3 |
| 5 | 50 GHz optical true time delay beamforming in hybrid optical/mm-wave access networks with multi-core optical fiber distribution显示文摘We propose and experimentally validate an optical true time delay beamforming scheme with straightforward integration into hybrid optical/millimeter(mm)-wave access networks. In the proposed approach, the most complex functions, including the beamforming network, are implemented in a central office, reducing the complexity and cost of remote antenna units. Different cores in a multi-core fiber are used to distribute the modulated signals to high-speed photodetectors acting as heterodyne mixers. The mm-wave carrier frequency is fixed to 50 GHz(VBand), thereby imposing a progressive delay between antenna elements of a few picoseconds. That true time delay is achieved with an accuracy lower than 1 ps and low phase noise. | álvaro Morales Idelfonso Tafur Monroy Fredrik Nordwall Tommi Sφrensen | 2018 | Chinese Optics Letters2018，16，4： | 2 |
| 6 | Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents显示文摘The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert atmosphere.The effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron microscopy.Compared with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass content.Complete metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave bagasse.These results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing agent.Therefore,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking. | Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 7 | Arginine vasopressin in the treatment of 50 patients with txstcardiotomy va- sodilatory shock显示文摘 | Morales D L S Gregg D Helman D N | 2000 | Ann Thorac Surg2000，69，1： | 1 |
| 8 | Addition of ultralow dose naloxone to postoperative morphine PCA:unchanged analgesia and opioid requirement but decreased incidence of opioid side effects显示文摘 | Cepeda M S Alvarez H Morales 0 | 2004 | Pain2004，107，12： | 1 |
| 9 | Is there a relationship between cholelithiasis and colorectal cancer显示文摘 | Novell F Moral A Pascual S | 1995 | Rev Esp Enfern Dig1995，87，4： | 1 |
| 10 | Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis 显示文摘 | MORALES P FIEDLER J L ANDRES S | 2008 | J Neurosci Res2008，86，12： | 1 |
| 11 | Effects of acute dietary Ironoverload in pigs (Sus scrofa) with induced type 2 diabetes mellitus显示文摘 | Espinoza A Morales S Arredondo M | 2014 | Biol Trace Elem Res2014，158，3： | 1 |
| 12 | Transpubic approach for lower urinary tract surgery: a 15-years experience 显示文摘 | Golimbu M A1-Askair S Morales P | 1990 | J Urol1990，143，1： | 1 |
| 13 | The characterization of a bio-assay of erectile function in a rat model 显示文摘 | Heaton JP Varrin S J Morales A | 1991 | J Urol1991，145，5： | 1 |
| 14 | Development and use of quality of care indicators for obstetric care in women with preeclampsia,severe preeclampsia,and severe morbidity显示文摘 | Perez C R Morales H R Doubova S V | 2007 | Hypertens Pregnancy2007，26，3： | 1 |
| 15 | Damage in hot rolling work rolls显示文摘 | Rafael Colás Jorge Ram??rez Ignacio Sandoval Julio C Morales Luis A Leduc | 1999 | Wear1999，，1： | 1 |
| 16 | Maternal vitamin D status in pregnancy and risk of lower respiratory tract infections, wheez- ing, and asthma in offspring显示文摘 | Morales E Romieu I Guerra S | 2012 | Epidemlology2012，23，1： | 1 |
| 17 | Cold and ambienr deck storage prior to processing as a critical control point for patulin accumulation 显示文摘 | Morales H Marin S Centelles X | 2007 | International Journal of Food Microbiology2007，116，2： | 1 |
| 18 | Azathioprine during pregnancy in systemic lupus erythematosus patients is not associated with poor fetal outcome 显示文摘 | Saavedra MA Sánchez A Morales S | 2015 | Clin Rheumatol2015，34，7： | 1 |
| 19 | C677T polymorphism of the methylentetrahydrofolate reductase gene in mothers of children affected with neural tube defects显示文摘 | Morales M A Méndez K Solís E | 2015 | Investigacion clinica2015，56，3： | 1 |
| 20 | Effect of carotenoid source and dietary lipid content on blood astaxanthin concentration in rainbow trout ( Oncorhynehus mykiss) 显示文摘 | BARBOSA M J MORAl S R CHOUBERT | 1999 | Aquaculture1999，176，34： | 1 |
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