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| 1 | Impact of Helicobacter pylori on the healing process of the gastric barrier显示文摘AIM To determine the impact of selected well defined Helicobacter pylori(H. pylori) antigens on gastric barrier cell turnover.METHODS In this study,using two cellular models of gastric epithelial cells and fibroblasts,we have focused on exploring the effects of well defined H. pylori soluble components such as glycine acid extract antigenic complex(GE),subunit A of urease(Ure A),cytotoxin associated gene A protein(Cag A) and lipopolysaccharide(LPS) on cell turnover by comparing the wound healing capacity of the cells in terms of their proliferative and metabolic activity as well as cell cycle distribution. Toxic effects of H. pylori components have been assessed in an association with damage to cell nuclei and inhibition of signal transducer and activator of transcription 3(STAT3) phosphorylation. RESULTS We showed that H. pylori GE,Cag A and Ure A promoted regeneration of epithelial cells and fibroblasts,which is necessary for effective tissue healing. However,in vivo increased proliferative activity of these cells may constitute an increased risk of gastric neoplasia. In contrast,H. pylori LPS showed a dose-dependent influence on the process of wound healing. At a low concentration(1 ng/m L) H. pylori LPS accelerated of healing epithelial cells,which was linked to significantly enhanced cell proliferation and MTT reduction as well as lack of alterations in cell cycle and downregulation of epidermal growth factor(EGF) production as well as cell nuclei destruction. By comparison,H. pylori LPS at a high concentration(25 ng/m L) inhibited the process of wound repair,which was related to diminished proliferative activity of the cells,cell cycle arrest,destruction of cell nuclei and downregulation of the EGF/STAT3 signalling pathway.CONCLUSION In vivo H. pylori LPS driven effects might lead to the maintenance of chronic inflammatory response and pathological disorders on the level of the gastric mucosal barrier. | Eliza Mnich Magdalena Kowalewicz-Kulbat Paulina Sicińska Krzysztof Hinc Michal Obuchowski Adrian Gajewski Anthony P Moran Magdalena Chmiela | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 2 | Endoscopic evaluation in diagnosis and management of inflammatory bowel disease显示文摘Endoscopy is a keystone in the management of patients with inflammatory bowel disease(IBD).It is the fundamental diagnostic tool for IBD,and can help discern between ulcerative colitis and Crohn's disease.Endoscopic assessment provides an objective end point in clinical trials,and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy.Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy,and chromoendoscopy.Technological advances enable improved visualization and focused biopsy sampling.Endoscopic resection and close surveillance of dysplastic lesions where feasible is recommended instead of prophylactic colectomy. | Carthage P Moran Barra Neary Glen A Doherty | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 3 |
| 3 | Premature failure of externally plated reinforced concrete beams 显示文摘 | Oehlers D J Moran J P | 1990 | Journal of Structural Engineering1990，116，4： | 2 |
| 4 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 5 | Microcontact printing of catalytic nanoparticles for selective electroless deposition of metals on nonplanar polymeric substrates 显示文摘 | Ng W K Wu L Moran P M | 2002 | Appl Phys Lett2002，81，16： | 1 |
| 6 | The interpretation on statistical maps 显示文摘 | MORAN P | 1948 | Journal of the Royal Statistical Society1948，10，： | 1 |
| 7 | The interpretation of statistical maps显示文摘 | MORAN P | 1948 | J R Stat Soc B1948，，10： | 1 |
| 8 | Notes on continuous stochastic phenomena显示文摘 | Moran P | 1950 | Bi- ometrika1950，，37： | 1 |
| 9 | The natural history of self- harm from adolescence to young adulthood:a population-based cohort study显示文摘 | Moran P Coffey C Romaniuk H | 2012 | The Lancet2012，379，9812： | 1 |
| 10 | The interpretation of statistical maps 显示文摘 | Moran P | 1948 | J R Stat Soc B1948，，10： | 1 |
| 11 | Polyvinyl alcohol particles sizeand suspension characteristerics显示文摘 | Moran C J Cross D T | 1995 | Am J Neuroradiol1995，16，6： | 1 |
| 12 | Notes on continuous stochastic phenomena显示文摘 | MORAN P A P | 1950 | Biometrika1950，37，12： | 1 |
| 13 | Early- and long-term out- come data of patients with pseudomyx- oma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperi- toneal chemotherapy 显示文摘 | Chua T C Moran B J Sugarbaker P H | 2012 | J Clin On- col2012，30，20： | 1 |
| 14 | Robot-assisted radical prostatectomy compared with open and laparoscopic approaches:a systematic review and meta-analysis显示文摘 | Moran P S O'neill M Teljeur C | 2013 | Int J Urol2013，20，3： | 1 |
| 15 | The role of callous and un- emotional traits in the diagnosis of conduct disorder显示文摘 | Rowe R Maughan B Moran P | 2010 | J Child Psychol Psyc2010，51，6： | 1 |
| 16 | The interpretation on statistical maps显示文摘 | Moran P | | 0，，02： | 1 |
| 17 | Stress-strain model for fiber-reinforced polymer-confined concrete显示文摘 | Moran D A Pantelides C P | 2002 | Journal of Composites for Construction2002，6，4： | 1 |
| 18 | A Test for the serial dependence of residuals显示文摘 | Moran P | 1950 | Biometrika1950，，37： | 1 |
| 19 | Bad for practice:a critique of transaction costs theory显示文摘 | | 1996 | Academy of Management Review1996，21，2： | 1 |
| 20 | Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies 显示文摘 | Zarling J M Moran P A Haffar O | 1990 | Nature1990，347，6288： | 1 |
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