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| 1 | Amyloid positron emission tomography and cognitive reserve显示文摘Alzheimer's disease(AD) is characterized by a nonlinear progressive course and several aspects influence the relationship between cerebral amount of AD pathology and the clinical expression of the disease. Brain cognitive reserve(CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. CR phenomenon contributed to explain the disjunction between the degree of neurodegeneration and the clinical phenotype of AD. The possibility to track brain amyloidosis(Aβ) in vivo has huge relevance for AD diagnosis and new therapeutic approaches. The clinical repercussions of positron emission tomography(PET)-assessed Aβ load are certainly mediated by CR thus potentially hampering the prognostic meaning of amyloid PET in selected groups of patients. Similarly, amyloid PET and cerebrospinal fluid amyloidosis biomarkers have recently provided new evidence for CR. The present review discusses the concept of CR in the framework of available neuroimaging studies and specifically deals with the reciprocal influences between amyloid PET and CR in AD patients and with the potential consequent interventional strategies for AD. | Matteo Bauckneht Agnese Picco Flavio Nobili Silvia Morbelli | 2015 | World Journal of Radiology2015，7，12： | 3 |
| 2 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 3 | Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk显示文摘AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F) uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS: Seventy-eight patients(44 females,mean age 63,range 44-83) underwent whole body 18F-Na F positron emission tomography/computed tomography. Cardiovascular risk(CVR) was used to divide these patients in three categories: Low(LR),medium(MR) and high risk(HR). 18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS: A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84 ± 0.76 vs 1.07 ± 0.3,P < 0.001),but also between MR and HR-LR(1.4 ± 0.4,P < 0.02 and P < 0.01,respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P < 0.01). Myocardial uptake provided an effective CVR classes stratification(P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R = 0.67),but it peaked when correlating the descending thoracic segment(R = 0.75),in comparison with the aortic arch and the ascending segment(R = 0.55 and 0.53,respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients' risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination. | Francesco Fiz Silvia Morbelli Matteo Bauckneht Arnoldo Piccardo Giulia Ferrarazzo Alberto Nieri Nathan Artom Manlio Cabria Cecilia Marini Marco Canepa Gianmario Sambuceti | 2016 | World Journal of Radiology2016，8，1： | 2 |
| 4 | Amnestic mild cognitive impairment in Parkinson's disease:a brain perfusion SPECT study显示文摘 | Nobili F Abbruzzese G Morbelli S | 2009 | Mov Disord2009，24，3： | 1 |
| 5 | A seismic vulnerability index for confined masonry shear wall buildings and a relationship with the damage 显示文摘 | Kenneth A Gent Franch Gian M Giuliano Morbelli Maximiliano A Astroza Inostroza | 2008 | Engineering Structures2008，30，10： | 1 |
| 6 | Refractive and Aberrometric Outcomes of Intracorneal Ring Segments for Keratoconus: Mechanical versus Femtosecond-assisted Procedures显示文摘 | David P. Pi?ero Jorge L. Alio Bassam El Kady Efekan Coskunseven Hector Morbelli Antonio Uceda-Montanes Miguel J. Maldonado Diego Cuevas Inmaculada Pascual | 2009 | Ophthalmology2009，，9： | 1 |
| 7 | Cognitive impairment in degenerative parkonsonisms:role of radionuclide brain imaging 显示文摘 | Arnaldi D Morbelli S Morrone E | 2012 | Mov Disord2012，6，1： | 1 |
| 8 | Resting metabolic connectivity in prodromal Alzheimer’s disease. A European Alzheimer Disease Consortium (EADC) project显示文摘 | Silvia Morbelli Alex Drzezga Robert Perneczky Giovanni B. Frisoni Anna Caroli Bart N.M. van Berckel Rik Ossenkoppele Eric Guedj Mira Didic Andrea Brugnolo Gianmario Sambuceti Marco Pagani Eric Salmon Flavio Nobili | 2012 | Neurobiology of Aging2012，，： | 1 |
| 9 | Diahetes impairs the vascular recruitment of normal stem cells by oxidant damage,reversed by increases in pAMPK,heme oxygenase-1,and adiponectin显示文摘 | Sambuceti G Morbelli S | 2009 | Stem Cells2009，27，2： | 1 |
| 10 | All-trans retinoic acid skews monocyte differentiation into interleukin-12-secreting den-dritic-like cel显示文摘 | Mohty M Morbelli S Isnardon D | 2003 | Br J Haematol2003，122，5： | 1 |
| 11 | Uptake and compartmentalization of fluorescent lipid analogs in larval Schistosoma mansoni显示文摘 | Furlong ST Thibault KS Morbelli LM | 1995 | J Lipid Res1995，36，1： | 1 |
| 12 | Mor- phology and ultrastructure of megaspores and mi- crospores of Isoetes savatieri Franchet (Lycophyta) 显示文摘 | Macluf C C Morbelli M A Giudice G E | 2003 | RevPalaeobotPalyno2003，126，： | 1 |
| 13 | Micro- spore morphology of Isoetes species (Lycophyta) from southern South America 显示文摘 | Macluf C C Morbelli M A Giudice G E | 2006 | Bot Rev2006，72，2： | 1 |
| 14 | Mesenchymal stem cells impair ill vivo T-cell priming by dendritic cells显示文摘 | Chiesa S Morbelli S Morando S | 2011 | Proc Natl Acad Sci USA2011，108，17： | 1 |
| 15 | Could显示文摘 | PICCARDO A FOPPIANI L MORBELLI S | 2011 | QJ Nucl Med Mol Imaging2011，550，： | 1 |
| 16 | Whole-body e- valuation of MIBG tissue extraction in a mouse model of long- lasting type I diabetes and its relationship with norepineph- rine transport protein concentration显示文摘 | KUSMIC C MORBELLI S MARINI C | 2008 | J Nucl Med2008，49，10： | 1 |
| 17 | Radionuclide brain imaging correlates of cognitive impairment in Parkinson's dis- ease(PD)显示文摘 | Nobili F Morbelli S Arnaldi D | 2011 | J Neurol Sei2011，310，12： | 1 |
| 18 | Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells 显示文摘 | Chiesa S Morbelli S Morando S | 2011 | Proc Ncad Sci U S A2011，108，17： | 1 |
| 19 | Spore wall uhrastructure in Anogramma species (Pteridaceae) from Ar- gentina显示文摘 | RAMOS G J P MORBELLI M A GIUDICE G E | 2004 | Grana2004，43，： | 1 |
| 20 | Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin显示文摘 | Sambuceti G Morbelli S Vanella L | 2009 | Stem Cells2009，27，2： | 1 |
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