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| 1 | Vascular invasion in pancreatic cancer:Imaging modalities,preoperative diagnosis and surgical management显示文摘Pancreatic cancer is associated with a poor prognosis,and surgical resection remains the only chance for curative therapy.In the absence of metastatic disease,which would preclude resection,assessment of vascular invasion is an important parameter for determining resectability of pancreatic cancer.A frequent error is to misdiagnose an involved major vessel.Obviously,surgical exploration with pathological examination remains the'gold standard'in terms of evaluation of resectability,especially from the point of view of vascular involvement.However,current imaging modalities have improved and allow detection of vascular invasion with more accuracy.A venous resection in pancreatic cancer is a feasible technique and relatively reliable.Nevertheless,a survival benefit is not achieved by curative resection in patients with pancreatic cancer and vascular invasion.Although the discovery of an arterial invasion during the operation might require an aggressive management,discovery before the operation should be considered as a contraindication.Detection of vascular invasion remains one of the most important challenges in pancreatic surgery.The aim of this article is to provide a complete review of the different imaging modalities in the detection of vascular invasion in pancreatic cancer. | Nicolas C Buchs Michael Chilcott Pierre-Alexandre Poletti Leo H Buhler Philippe Morel | 2010 | World Journal of Gastroenterology2010，16，7： | 29 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Influence of sludge-amendant or nutrient addition on the biodegradation of the herbicide isoproturon in soil显示文摘 | Perrin-Ganier C Schiavon F Morel J L Schiavon M | 2001 | Chemosphere2001，44，： | 1 |
| 4 | Nonlinear absorption spectra of transparent organic crystals for optical limiting applications at visible wavelengths显示文摘 | Morel Y lbanez A Nguefack C | 2000 | Synth Met2000，115，： | 1 |
| 5 | Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation显示文摘 | Boniface K Diveu C Morel F | 2007 | J Immunol2007，178，7： | 1 |
| 6 | Effect of non-starch polysaccharides and resistant starch on mucin secretion andendogenous amino acid losses in pigs 显示文摘 | Morel P C H Melai J Eady S L eta! | 2005 | Asian Aust J Anim Sci2005，18，11： | 1 |
| 7 | Mass spectrometric approach for screening modifications of total serum N-glycome in human diseases:application to cirrhosis显示文摘 | MORELLE W FLAHAUT C MICHALSKI J C | 2006 | Glycobiology2006，16，4： | 1 |
| 8 | Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium显示文摘 | Rasika S Han J Mauduit C Raccurt M Morel G | 2003 | J Nevi2003，23，5： | 1 |
| 9 | Urban soil management:a growing concern显示文摘 | MOREL J-L | 2001 | SoilSci2001，65，1： | 1 |
| 10 | Results of the international Pu-2000 exercise for plutonium isotopic composition measurements显示文摘 | Morel J Bickel M Hill C | 2004 | Apllied Radiation and Isotopes2004，60，： | 1 |
| 11 | Fertile hypomorphic Argonaute (agol)mutants impaired on post transcriptional gene silencing and virus resistans显示文摘 | Morel J B Godon C Mourrain P | 2002 | Plant Cell2002，14，3： | 1 |
| 12 | Urban soil management a growing concern显示文摘 | De Kmpe C R Morel J L | 2001 | Soil Science2001，165，： | 1 |
| 13 | Invited review: Organic and Conventionally Produced milk-An Evaluation of Factors Influencing Milk Composition显示文摘 | SCHWENDEL B H WESTER T J MOREL P C H | 2015 | Journal of Dairy Science2015，98，2： | 1 |
| 14 | Circadian clock regulation of starch metabolism establishes GBSSI as a major contributor to amylopectin synthesis in Chlamydomonas reinhardtii 显示文摘 | Ral J Colleoni C Wattebted F Dauville D Nempont C Deschamps P Li Z Morell M Chibbar R Purton S | 2006 | Plant Physiology2006，142，1： | 1 |
| 15 | Effects of feeding vitamin A and lactoferrin on epithelium of lymphoid tissues of intestine of neonatal calves 显示文摘 | Muri C Morel C | 2005 | J Dairy Sci2005，88，3： | 1 |
| 16 | External phosphorus requirements of mycorrhizal and non-mycorrhizal barley and soybean plants 显示文摘 | Plenehette C Morel C | 1996 | Biology and Fertility of Soils1996，21，： | 1 |
| 17 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 18 | Generation of breast cancer stem cells through epithelial - mesenchymal transition显示文摘 | MOREL AP LIEVRE M THOMAS C | 2008 | PLoS One2008，3，9： | 1 |
| 19 | Urban soil management: A growing concern显示文摘 | De Kimpe C R Morel J L | 2000 | Soil Science2000，165，： | 1 |
| 20 | soil management: agrow- hag concern 显示文摘 | Kimpe D C R Morel J L Urban | 2000 | Soil Science2000，165，1： | 1 |
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