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| 1 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016,13,3: | 12 |
| 2 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016,96,33: | 6 |
| 3 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018,26,4: | 3 |
| 4 | A pratical model for organic richness from porosity and resistivty logs 显示文摘 | Passey Q R Creaney S Kulla J B Moretti F J Stroud J D | 1990 | AAPG Bull1990,74,12: | 1 |
| 5 | Levels of renal and extrarenal sympathetic drive in Angiotensin Ⅱ-induced hypertension显示文摘 | Burke S L Evans R G Moretti J L | | 0,,04: | 1 |
| 6 | Soft-sediment deformation structures induced by earthquakes(seismites)in Pliocene lacustrine deposits(Guadix-Baza Basin,Central Betic Cordillera)显示文摘 | Alfaro P Moretti M Soria J M | 1997 | Ecological Geologicae Helvetiae1997,90,: | 1 |
| 7 | Suicidal ideation in an ado- lescent clinical sample:attachment patterns and clinical impli- eations显示文摘 | LESSARD J C MORETTI M M | 2005 | Journal of Adolescence2005,21,4: | 1 |
| 8 | Ctyptorchidism and semen quality: TEM and molecular study 显示文摘 | J MORETTI E DI CAIRANO G CAPITANI S | 2007 | Andrology2007,28,1: | 1 |
| 9 | The in vitro characterization of polyene glycosyltransfcrascs AmphDl and NysDl 显示文摘 | Zhang C Moretti R Jiang J | 2008 | ChemBioChem2008,9,15: | 1 |
| 10 | Postnatal isl1+cardioblasts enter fully differentiated cardiomyocyte lineages显示文摘 | Laugwitz KL Moretti A Lam J | | 0,,7026: | 1 |
| 11 | Cancer: NF-κB regu- lates energy metabolism 显示文摘 | Moretti M Benneet J Tomatore L | 2012 | Int J Biochem Cell Biol2012,44,12: | 1 |
| 12 | Postnatal isl1+cardioblasts enter fully differentiated cardiomyocyte lineages显示文摘 | Laugwitz KL Moretti A Lam J | 2005 | Nature2005,433,7026: | 1 |
| 13 | Postnatal isll + cardioblasts enter fully differentiated cardio-myocyte lineages 显示文摘 | Laugwitz KL Moretti A Lam J | 2005 | Nature2005,433,6: | 1 |
| 14 | Geochemical characterization of source rocks, rude oils and gases of North Cuba 显示文摘 | Magnier C Moretti I Lopez J O | 2004 | Marine and Petroleum Geology2004,21,: | 1 |
| 15 | The role of ^99Tc^m-MIBI acintigraphy in the assessment of MDRI overexperssion in patients with musculoskeletal sarcornas:comparison with therapy response显示文摘 | Burak Z Ersoy O Moretti J | 2001 | Eur J Nucl Med2001,28,9: | 1 |
| 16 | Use of throm- boelastography to assess the combined role of pregnancy and obesity on coagulation : A prospective study 显示文摘 | SHARMA S UPRICHARD J MORETTI A | 2013 | International journal of obstetric anesthesia2013,22,2: | 1 |
| 17 | Blood-brain barrier dysfunction in disorders of the developing brain 显示文摘 | Moretti R Pansiot J Bettati D | 2015 | Front Neurosci2015,9,: | 1 |
| 18 | A system approach to SO3mitigation显示文摘 | Moretti A L Triscori R J Ritzenthaler D P | 2006 | The Babcock and Wilcox Company y American Electric Power2006,,: | 1 |
| 19 | Biology of Isl1+ cardiac progenitor cells in development and disease显示文摘 | Moretti A Lam J Evans SM | 2007 | Cell Mol Life Sci2007,64,6: | 1 |
| 20 | Fuzzy markovian segmentation in application of magnetic resonance images显示文摘 | Ruan S Moretti B Fadili J | 2002 | Comput Vision Image Underst2002,85,1: | 1 |