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| 1 | A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia显示文摘This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive azoospermia.All cases at a single center between 2012 and 2016 were included.Operative approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm extraction.Blastocyst culture was exclusively utilized prior to transfer.The primary outcome was live birth rate.Secondary outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was performed.Seventy-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were analyzed.The live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no different.Pregnancy rates were no different through the first transfer cycle.However,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per patient.Thus,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort. | Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis Richard T Scott Jr James M Hotaling | 2020 | Asian Journal of Andrology2020，22，2： | 2 |
| 2 | Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity显示文摘BACKGROUND Benzylamine and methylamine activate glucose uptake in adipocytes.For tyramine,this effect has even been extended to cardiomyocytes.AIM To investigate the effects of catecholamines and other amines on glucose uptake.METHODS A screening compared 25 biogenic amines on 2-deoxyglucose(2-DG)uptake activation in rat adipocytes.Pharmacological approaches and transgenic mouse models were then used to decipher the mode of action of several hits.RESULTS In rat adipocytes,insulin stimulation of 2-DG uptake was reproduced with catecholamines.100μmol/L or 1 mmol/L adrenaline,noradrenaline,dopamine and deoxyepinephrine,maximally activated hexose transport only when sodium orthovanadate was added at 100μmol/L.Such activation was similar to that already reported for benzylamine,methylamine and tyramine,well-recognized substrates of semicarbazide-sensitive amine oxidase(SSAO)and monoamine oxidase(MAO).Several,but not all,tested agonists ofβ-adrenoreceptors(β-ARs)also activated glucose transport whileα-AR agonists were inactive.Lack of blockade byα-andβ-AR antagonists indicated that catecholamine-induced 2-DG uptake was not mediated by AR stimulation.Adipocytes from mice lackingβ1-,β2-andβ3-ARs(triple KO)also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100μmol/L vanadate.The MAO blocker pargyline,and SSAO inhibitors did not block the effects of adrenaline or noradrenaline plus vanadate,which were blunted by antioxidants.CONCLUSION Catecholamines exert unexpected insulin-like actions in adipocytes when combined with vanadium.For limiting insulin resistance by activating glucose consumption at least in fat stores,we propose that catecholamine derivatives combined with vanadium can generate novel complexes that may have low toxicity and promising anti-diabetic properties. | Jessica Fontaine Geneviève Tavernier Nathalie Morin Christian Carpéné | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 3 | Contact Materials Performances Under Break Arc in Automotive Applications显示文摘 | Jemma N B Jaennot D | 2000 | IEEE Trans Comp2000，23，2： | 1 |
| 4 | Basal replication of hepatitis C virus in nude mice harboring human tumor显示文摘 | Labonte P Morin N Bowlin T | 2002 | J Med Virol2002，66，3： | 1 |
| 5 | Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys显示文摘 | Morin N Gr~ goire L Gomez-Mancilla B | 2010 | Neuropharmacology2010，58，7： | 1 |
| 6 | Patients'global evaluation of analgesia and safety of injected parecoxib for postoperative pain:a quantitative systematic review显示文摘 | Kranke P Morin AM Roewer N | 2004 | Anesth Analg2004，99，3： | 1 |
| 7 | DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells显示文摘 | Morin S Beaulieu N | 2003 | Nat Genet2003，33，1： | 1 |
| 8 | Transition from the Anodic Arc Phase to the Cathodic Metallic Arc Phase in Vacuum at Low DC Electrical LeveI显示文摘 | Ben Jemma N Morin L | 2002 | IEEE Transactions on Components Packaging Technologies2002，25，4： | 1 |
| 9 | Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma显示文摘 | Korinek V Barker N Morin PJ | 1997 | Science1997，275，5307： | 1 |
| 10 | The efficacy and safety of transdermal scopolamine for the prevention of postoperative nausea and vomiting : a quantitative systematic review 显示文摘 | Kranke P Morin AM Roewer N | 2002 | Anesth Analg2002，95，1： | 1 |
| 11 | Apelin ( 65 - 77 ) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells 显示文摘 | Masri B Morin N Cornu M | 2004 | FASEB J2004，18，15： | 1 |
| 12 | Reverse transcription - multiplex PCR assay for simultaneous detection of Escherichia coli O157: H7, vibrio cholera O1, and Salmonella Typhi 显示文摘 | Morin N J Gong ZL Li XF | 2004 | Clin Chem2004，50，11： | 1 |
| 13 | Produc- tion of concentrated Lactococcus lactis subsp, cremoris suspension in calcium alginate beads显示文摘 | MORIN N BERNIER-CARDON M CHAMPAGNE C P | 1992 | Appl Environ Microbiol1992，58，： | 1 |
| 14 | Claudin-7 is frequently overexpressed in ovarian cancer and promotes invasion 显示文摘 | Dahiya N Becker KG Wood WH 3rd Zhang Y Morin PJ | 2011 | PLoS One2011，6，22： | 1 |
| 15 | Retention behavior of D,L-dansyl-amino acids on a human serum albumin chiral stationary phase:effect of a mobile phase modifier显示文摘 | ]Peyrin E Guillaume Y C Morin N | 1998 | Chromatography A1998，808，： | 1 |
| 16 | Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/-colon carcinoma显示文摘 | Korinek V Barker N Morin P J | 1997 | Science1997，275，5307： | 1 |
| 17 | 2012 Eluci- dation of the gas vesicle gene clusters in cyanobacteria of the genus Arthrospira ( Oscillatoriales, Cyanophyta ) and correlation with ITS phylogeny显示文摘 | Miklaszewska M Waleron M Morin N | 2012 | Eur J Phycol2012，186，11： | 1 |
| 18 | In vitro embryo production in the cow:An effective alternative to the conventional embryo production approach显示文摘 | BOUSQUET D TWAGRAMUBGU H MORIN N | | 0，，01： | 1 |
| 19 | Phylogeography,genetic structure,and diversity in the dhole(Cuon alpinus)显示文摘 | Iyengar A Babu VN Hedges S Venkataraman AB Maclean N Morin PA | | 0，，： | 1 |
| 20 | Implementing an intedacuhy series of courses on interprofessional colleboration in prelicensure health sci- ence currlculums显示文摘 | Dumont S Briere N Morin D et el | 2010 | Educ Health(Abingdon)2010，23，1： | 1 |
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