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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Static drop on an inclined plate: analysis by the finite element method 显示文摘 | R A Brown F MOrr Jr L E Scriven | 1980 | Journal Colloid Interface Science1980，73，1： | 1 |
| 3 | 18F-FDG uptake in vitro:aspects of method and effects of treatment with gemcitabine显示文摘 | Haberkorn U Morr I Oberdorf F | 1994 | J Nucl Med1994，35，11： | 1 |
| 4 | Semiconstrained arthroplas-ty for the treatment of rheumatoid of the elbow显示文摘 | MORRE B F ADAMS R A | 1992 | J Bone Joint Surg (Am)1992，74，： | 1 |
| 5 | Quantitative measurement of geometrical isomerization during the partial hydrogenation of triglyceride oils显示文摘 | Albright L F Allen R R Morre M C | 1970 | J Am Oil Chem Soc1970，47，： | 1 |
| 6 | Formation of cation-exchanged clay nanocomposite 显示文摘 | Grant D Barber Robson F Storey Robert B Morre | 1999 | Polymer Preprints1999，40，2： | 1 |
| 7 | Oxidoreduction at the plasma membrane: Relation to growth and transport in cells 显示文摘 | CRANE F L MORRE D J LOW H | 1994 | Biochem Biopsy''s Res Commune1994，126，： | 1 |
| 8 | Functionalization of PEG and monomethyoxy-PEG显示文摘 | Buckmann A F Morr M Johansson G | 1981 | Makromol Chem1981，182，1： | 1 |
| 9 | Preparation of technical grade polyethene glycol(PEG)(Mr2000)-N6-(2-aminoethyl)-NADH by a procedure adaptable to large-scale synthesis显示文摘 | Buckman A F Morr M Kula M R | 1987 | Biotechnol Appl Biochem1987，，9： | 1 |
| 10 | Postinjury multiple organ failure : bimodal phenomenon 显示文摘 | MORRE F A SAUAIA A MOORE E E | 1996 | J Trauma1996，40，4： | 1 |
| 11 | Preparation of technical grade polyethylene glycol-N6-(2-aminoethyl)-NADH by a procedure adaptable tolarge-scale synthesis显示文摘 | Buckmann A F Morr M | 1987 | Biotechnol Appl Biochem1987，9，： | 1 |
| 12 | Indications and results of combined anterior-posterior approacaehes for spine turmor surgery 显示文摘 | Sundarsean N Steimberger AA Morre F | 1996 | J Neurosurg1996，85，： | 1 |
| 13 | Structural aspects of bovine oocyte maturation in vitro显示文摘 | Loos F Morre D M | 1992 | Mol Reorod Dev1992，31，： | 1 |
| 14 | Long acting inhaled β2 agonists in asthma therapy显示文摘 | Morre R H Khan A Dickey B F | 1998 | Chest1998，113，4： | 1 |
| 15 | Continued modification of the M-DRIS for soybean显示文摘 | HALLMARKW B BEVERLYY R B MORR/SH F | 1990 | Commun in Soil Sci PlantAnal1990，21，： | 1 |
| 16 | Preparation of technical grade polyethylene glycol (PEG) (Mr 20, 000)-N6-(2-aminoethyl)-NADH by a procedure adaptable to large-scale synthesis 显示文摘 | Buckmann A F Morr M Kula M-R | 1987 | Biotechnol Appl Bio- chem1987，9，： | 1 |
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