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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Tracking student behavior, persistence and achievement in online courses显示文摘 | Morris L Finnegan C Wu S | 2005 | The Internet and Higher Education2005，8，： | 1 |
| 3 | Seed-coat dormancy in GrevilleaUnearifolia: little change in permeability to an apoplastictracer after treatment with smoke and heat 显示文摘 | Briggs C L Morris E C | 2008 | Annals ofBotany2008，101，5： | 1 |
| 4 | Postharvest biological control of Penicillium digitatum decay on citrus fruit by Bacillus pumilus 显示文摘 | Huang Y B L Wild S C Morris | 1992 | Annals of Applied Biology1992，120，： | 1 |
| 5 | A novel potent strategy for gene delivery using a single peptide vector as a carrier显示文摘 | Morris M C Chaloin L Mery J | 1999 | Nucleic Acids Res1999，27，17： | 1 |
| 6 | The ballistic performance of confined Al2O3 ceramic tiles 显示文摘 | Anderson C E Morris B L | 1992 | Int J Impact Eng1992，12，2： | 1 |
| 7 | Substrate-induced phenotypic switches of human smooth muscle cells: an in vitro study of in-stent restenosis activation pathways显示文摘 | GUILDFORD A L STEWART H J MORRIS C | 2011 | J R Soc Interface2011，8，58： | 1 |
| 8 | Lunar surface topography显示文摘 | Rennilson J J Dragg J L Morris E C Shoemaker E M Turkevich A | 1966 | Surveyor I mission report part Ⅱ:Scientific data and results NASA JPL Technical Report1966，32，： | 1 |
| 9 | Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RTPCR) 显示文摘 | Morris D L and Davila J C | 1996 | Biochemical Pharmacology1996，52，： | 1 |
| 10 | Sources of variation for starch gelatinization, pasting and gelation properties in wheat 显示文摘 | Zeng M Morris C F Batey I L | 1997 | Cereal Chem1997，74，1： | 1 |
| 11 | Exten- sive troponin I and T modification detected in serum from patients with acute myocardial infarction 显示文摘 | PAYNE R C BLUESTEIN B I MORRIS D L | 2001 | Cir- culation2001，104，5： | 1 |
| 12 | Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction ( RT-PCR ) 显示文摘 | Morris D L Davila J C | 1996 | Biochemical Pharmacology1996，52，： | 1 |
| 13 | Biological Psychiatry显示文摘 | Modahl C Green L Fein D Morris M Waterhouse L Feinstein C Levin H | 1998 | 43(4):2701998，43，4： | 1 |
| 14 | Heritabilities and genetic correlations for live weights and fibre traits in New Zealand cashmere goats显示文摘 | Bigham M L Morris C A Southey B R | 1993 | Livest Prod Sci1993，33，： | 1 |
| 15 | Identification and characterization of some bacterial membrane sulfhydryl groups which are targets of bacteriostatic and antibiotic action显示文摘 | MORRIS S L WALSH F C HANSEN J N | 1984 | Biol Chem1984，259，13： | 1 |
| 16 | Wheat grain hardness among chromosome 5D homozygous recombinant substitution line susing different method so measurement显示文摘 | MORRIS C F DEMACON V L GIROUX M J | 1999 | Cereal Chem1999，76，2： | 1 |
| 17 | Biological Psychiatry显示文摘 | Green L A Fein D Modahl C Feinstein C Waterhouse L Morris M | 2001 | 50(8):6092001，50，8： | 1 |
| 18 | Electroencephalographic and psychometric differences between boys with and without attention deficit hyperactivity disorder(ADHD): a pilot study 显示文摘 | Cox DJ Kovatchev BP Morris JB Jr Phillips C Hill RJ Merkel L | 1998 | Appl Psychophysiol Biofeedback1998，23，3： | 1 |
| 19 | Effects of chemical inhomogenities on grain growth and microstructure in Al2O3显示文摘 | Handwerker C A Morris P A Coble R L | 1989 | J Am Ceram Soc1989，72，1： | 1 |
| 20 | Utility of breast magnetic resonance imaging in patients with occult primary breast cancer显示文摘 | Buchanan C L Morris E A Dorn P L | 2005 | Ann Surg Oncol2005，12，12： | 1 |
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