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| 1 | Beyond the stomach: An updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment显示文摘Helicobacter pylori(H. pylori) is an extremely common, yet underappreciated, pathogen that is able to alter host physiology and subvert the host immune response, allowing it to persist for the life of the host. H. pylori is the primary cause of peptic ulcers and gastric cancer. In the United States, the annual cost associated with peptic ulcer disease is estimated to be $6 billion and gastric cancer kills over 700000 people per year globally. The prevalence of H. pylori infection remains high(> 50%) in much of the world, although the infection rates are dropping in some developed nations. The drop in H. pylori prevalence could be a double-edged sword, reducing the incidence of gastric diseases while increasing the risk of allergies and esophageal diseases. The list of diseases potentially caused by H. pylori continues to grow; however, mechanistic explanations of how H. pylori could contribute to extragastric diseases lag far behind clinical studies. A number of host factors and H. pylori virulence factors act in concert to determine which individuals are at the highest risk of disease. These include bacterial cytotoxins and polymorphisms in host genes responsible for directing the immune response. This review discusses the latest advances in H. pylori pathogenesis, diagnosis, and treatment. Up-todate information on correlations between H. pylori and extragastric diseases is also provided. | Traci L Testerman James Morris | 2014 | World Journal of Gastroenterology2014，20，36： | 47 |
| 2 | Radial artery access site complications during cardiac procedures,clinical implications and potential solutions: The role of nitric oxide显示文摘Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery,as this is considered to be safer than the femoral approach.However,despite improvements in technology and techniques,complications can occur.The most common complication,arterial spasm,can cause intense pain and,in some cases,procedural failure.The incidence of spasm is dependent on several variables,including operator experience,artery size,and equipment used.An antispasmolytic cocktail can be applied to reduce spasm,which usually includes an exogenous nitric oxide(NO)donor(glyceryl trinitrate).NO is an endogenous local vasodilator and therefore is a potential target for anti-spasm intervention.However,systemic administration can result in unwanted side-effects,such as hypotension.A method that adopts local delivery of NO might be advantageous.This review article describes the mechanisms involved in radial artery spasm,discusses the advantages and disadvantages of current strategies to reduce spasm,and highlight the potential of NO-loaded nanoporous materials for use in this setting. | Emma M Coghill Timothy Johnson Russell E Morris Ian L Megson Stephen J Leslie | 2020 | World Journal of Cardiology2020，12，1： | 4 |
| 3 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 4 | Indolicidin,a novel bactericidal tridecapeptide amide from neutrophils显示文摘 | Selsted M E Novotny M J Morris W L | 1992 | J Biol Chem1992，267，： | 2 |
| 5 | Hepatocytes isolated from neoplastic liver-immunomagnetic purging as a new source for transplantation显示文摘AIM: To investigate whether hepatocytes isolated from macroscopically normal liver during hepatic resection for neoplasia could provide a novel source of healthy hepatocytes, including the development of reliable protocols for malignant cells removal from the hepatocyte preparation. METHODS: Hepatocytes were procured from resected liver of 18 patients with liver tumors using optimised digestion and cell-enrichment protocols. Suspensions of various known quantities of the HT-29 tumor cell line and patient hepatocytes were treated or not with Ep-CAM-antibody-coated immunomagnetic beads in order to investigate the effi cacy of tumor-purging by immunomagnetic depletion, using a semi-quantitative RT-PCR method developed to detect tumor cells. Immunomagnetic bead-treated or bead-untreated tumor cell-hepatocyte suspensions were transplanted intra-peritoneally in Balb/C nude mice to assess the rates of tumor development. RESULTS: Mean viable hepatocyte yield was 9.3 x 106 cells per gram of digested liver with mean viability of 70.5%. Immunomagnetic depletion removed tumor cells to below the RT-PCR detection-threshold of 1 tumor cell in 106 hepatocytes, representing a maximum tumor purging efficacy of greater than 400 000-fold. Transplanted, immunomagnetic bead-purged tumor cell-hepatocyte suspensions did not form peritonealtumors in Balb/C nude mice. Co-transplantation of hepatocytes with tumor cells did not increase tumorigenesis of the tumor cells. CONCLUSION: Immunomagnetic depletion appears to be an effective method of purging contaminating tumor cells to below threshold for likely tumorigenesis. Along with improved techniques for isolation of large numbers of viable hepatocytes, normal liver resected for neoplasia has potential as another clinically useful source of hepatocytes | Aravin Gunasegaram Javed Akhter Peng Yao Loreena A Johnson Stephen M Riodan David L Morris | 2008 | World Journal of Gastroenterology2008，14，32： | 2 |
| 6 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 7 | 射频消融(RFA)辅助的无血切肝技术显示文摘肝细胞癌(HCC)是世界上最常见的实体癌之一,而且肝脏是除淋巴结之外最常见转移癌的脏器。肝癌的治疗仍以手术切除为首选,根治性切除术后病人的5年生存率可达40%左右,然而肝切除对于外科医生的技术要求较高,有时术中出血极其难以控制。射频消融广泛地用于治疗无法手术切除的肝癌,甚至在部分病人身上取得了较好的远期效果。Habib第一次描述了RFA辅助的肝切除,他使用单极RFA探针预先处理切除面,术中出血明显地减少(30±10)ml。Morris在此基础上设计了一种新颖的双极RFA设备——InLine,其工作原理是双极RFA探针产生了一条精确的凝固带,进而封闭大到4mm的动脉和静脉,肝切除随之可以在这个无血管的平面进行,取得接近不出血的结果。在最近完成的一项国际多医疗中心研究中,笔者发现经过InLine治疗后,术中出血减少了63.88%。该文重点讲述了射频辅助的肝切除技术的原理,使用以及临床结果。射频消融辅助的肝切除可以适用于解剖和非解剖切除。这项技术易于使用,同时术后病人恢复良好。 | 姚鹏 王晓路 David L Morris | 2008 | 中华肝胆外科杂志2008，14，5： | 2 |
| 8 | Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress 显示文摘 | Park DS Morris E J Stefanis L | 1998 | J Neurosci1998，18，3： | 1 |
| 9 | Apoptosis in ischemia/reperfusion injury of human renal allografts 显示文摘 | Davies DR McLaren AJ Cerundolo L Morris PJ Fuggle SV | 1998 | Transplantation1998，66，7： | 1 |
| 10 | Electrical conduction models for isotropically conductive adhesive joints显示文摘 | MORRIS J E | 1997 | IEEE Transactions on Components Package Manufacturing Technology1997，20，1： | 1 |
| 11 | Tracking student behavior, persistence and achievement in online courses显示文摘 | Morris L Finnegan C Wu S | 2005 | The Internet and Higher Education2005，8，： | 1 |
| 12 | The impact of the bulk modulus of diesel fuels on fuel injection timing显示文摘 | Boehman A L Morris D Szybist J | 2004 | Energy & Fuels2004，18，6： | 1 |
| 13 | Foliar damage, spectral reflectance, and tissue ion concentrations of trees sprinkle irrigated with waters of similar salinity but different chemical composition显示文摘 | Devitt D A Morris R L Fenstermaker L K | 2005 | HortScience2005，40，3： | 1 |
| 14 | Breast lesion detec ted on MR imaging: features and positive predictive value 显示文摘 | Liberman L Morris EA LeeMJ | 2002 | AJR2002，179，： | 1 |
| 15 | Activity and structure of hydrotreating Ni,Mo,and Ni-Mo sulfide catalysts supported on γ-Al2O3-USY zeolite 显示文摘 | Dien L Nishijima A Morris D E | 1999 | J Catalysis1999，188，： | 1 |
| 16 | Electrocardiographic features of Wolff-Parkinson-White syndrome显示文摘 | Keating L Morris FP Brady WJ | 2003 | Emerg Med J2003，20，5： | 1 |
| 17 | Chord:a scalable peer-to-peer lookup protocol for Internet applications显示文摘 | STOICA I MORRIS R NOWELL D L | 2003 | IEEE/ACM Transactions on Networking2003，11，1： | 1 |
| 18 | Hapten-induced model of chronic inflammation and ulceration in the rat colon显示文摘 | MORRIS G P BECK P L HERRIDGE M S | 1989 | Gastrofnterology1989，96，3： | 1 |
| 19 | Systemic administration of Larginine benefits mdx skeletal muscle function显示文摘 | Barton ER Morris L Kawana M | 2005 | Muscle Nerve2005，32，6： | 1 |
| 20 | MR imaging of the breast with rotating delivery of excition off resonance clinical experience with pathologic correlation显示文摘 | Morris E A Schwartz L H Dershaw D D | 1993 | Radiology1993，187，2： | 1 |
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