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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Abnormalities of the heart and great arteries in first trimester chromosomally abnormal fetuses 显示文摘 | Hyett J Moscoso G Nicolaides K | 1997 | Am J Med Genet1997，69，： | 1 |
| 3 | Differentiation 'in vitro' of primary and immortalized porcine rues enchymal s tern cells into eardiomyocytes for cell transplantation 显示文摘 | Moscoso I Centrno A Lopez E | 2005 | Transplant Proc2005，37，1： | 1 |
| 4 | Allelic variation of polymorphic locus lytB,encoding a choline-binding protein,from streptococci of the mitis group显示文摘 | MOSCOSO M OBREGON V LOPEZ R | 2005 | Appl Environ Microbiol2005，71，： | 1 |
| 5 | Differentiation ' in vitro'' ot primary and immortalized porcine mesenchymal stem ceils into cardiomyocytes for cell transplantation 显示文摘 | Moscoso I Centrno A L6opez E | 2005 | Transplant Proc2005，37，1： | 1 |
| 6 | Comparative uterine effects on ovariectomized rats after repeated treatment with different vaginal estrogen formulations显示文摘 | Juan López-Belmonte Concepción Nieto José Estevez Juan L. Delgado Jaime Moscoso del Prado | 2012 | Maturitas2012，，4： | 1 |
| 7 | HLA-G,-E and -F:allelism,function and evolution显示文摘 | Serrano-Vela JI Pacheco R | 2006 | Transpl Immunol2006，17，1： | 1 |
| 8 | Efficacy of nitroglycerine infusion versus sublingual nifedipine in severe pro - eclampsia: a randomized, triple - blind, controlled trial 显示文摘 | Manzur - Verastequi S Mandeville PB Gordillo - Moscoso A | 2008 | Clin Exp Pharmacol Physiol2008，35，56： | 1 |
| 9 | Differentiation ' in vitro' of primary and immortalized porcine mesenchymal stem cells into cardiomyocytes for cell transplantation 显示文摘 | Moscoso I centrno A lopez E | 2005 | Tr-ansplant Proc2005，37，： | 1 |
| 10 | A systematic approach to functional reconstruction of the oral cavity following partial and total glossectomy 显示文摘 | Urken ML Moscoso JF Lawson W | 1994 | Arch Otolaryngol Head Neck Surg1994，120，6： | 1 |
| 11 | The anatomy of the umbilical,portal and hepatic venous systems in the human fetus at 14-19 weeks of gestation显示文摘 | Mavrides E Moscoso G Carvalho JS | 2001 | Ultrasound Obstet Gynecol2001，18，3： | 1 |
| 12 | Clinical impact of first and early second trimester fetal echocardiography on high risk pregnancies显示文摘 | Carvalho JS Moscoso G Tekay A | 2004 | Heart2004，90，8： | 1 |
| 13 | Biofilm formation by Streptococ- cus pneumoniae:role of choline, extracellular DNA, and capsularpolysaccharide in microbial accretion显示文摘 | Moscoso M Garcla E Lopez R | 2006 | J Bacteriol2006，188，22： | 1 |
| 14 | Defective neuromu- scular synaptogenesis in agrin deficient mutant mice显示文摘 | Gautam M Noakes P G Moscoso L | 1996 | Cell1996，85，4： | 1 |
| 15 | Differentiation in vitro of primary and immortalized porcine mes enchymal s tern cells into cardiomyocytes for cell transplantation 显示文摘 | Moscoso I Centrno A Lopez E | 2005 | Transplant Proc2005，37，1： | 1 |
| 16 | Reservoir characterization using stochastic initializations and the level set method显示文摘 | Rossmary Villegas Oliver Dora Miguel Moscoso | 2008 | Computers and Mathematics with Applications2008，56，2： | 1 |
| 17 | Mindfulness based stress reduction in post-treatment breast cancer patients: an examination of symptoms and symptom clusters显示文摘 | Cecile A. Lengacher Richard R. Reich Janice Post-White Manolete Moscoso Melissa M. Shelton Michelle Barta Nancy Le Pinky Budhrani | 2012 | Journal of Behavioral Medicine2012，，1： | 1 |
| 18 | Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells显示文摘 | Dagkessamanskaia A Moscoso M Henard V | 2004 | Mol Microbiol2004，51，4： | 1 |
| 19 | Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells显示文摘 | Dagkessamanskaia A Moscoso M Henard V | 2004 | Mol Microbiol2004，51，4： | 1 |
| 20 | First-trimester transabdominal fetal echocardiography显示文摘 | Carvalho JS Moscoso G Ville Y | 1998 | Lancet1998，351，： | 1 |
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