|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Possibility of COVID-19 eradication with evolution of a new omicron variant显示文摘COVID-19 has been a global health concern since 2019 until date.Global concerted efforts to combat this pandemic has resulted in a number of vaccines distributed across the globe.Although the presence of these vaccines produced quick interventions,dynamic mutation in the causal virus and the continuous evolution of new stains that defy available vaccines has given rise to pertinent questions.The most recent emergence of a new COVID-19 virus variant(omicron),the rapid spread and overwhelming rate of morbidity and mortality has reopened these questions for debate.This commentary summarizes major view on these questions and concludes that multiple approach including social behavioural measures,vaccination and antiviral drug would speed up elimination process. | Moses Okpeku | 2022 | Infectious Diseases of Poverty2022，11，2： | 0 |
| 2 | Morphological and microsatellite DNA diversity of Nigerian indigenous sheep显示文摘Background: Sheep is important in the socio-economic lives of people around the world. It is estimated that more than half of our once common livestock breeds are now endangered. Since genetic characterization of Nigerian sheep is still lacking, we analyzed ten morphological traits on 402 animals and 15 microsatellite DNA markers in 384 animals of the 4 Nigerian sheep breeds to better understand genetic diversity for breeding management and germplasm conservation. Results: Morphological traits of Uda and Balami were significantly (P < 0.05) higher than Yankasa, which were both higher than West African Dwarf (WAD) sheep. Stepwise discriminant analysis showed tail length, rump height, chest girth, ear length and chest depth as the most discriminating variables for classification. Mahalanobis distances show the least differentiation between Uda and Balami and the largest between WAD and Balami sheep. While 93.3% of WAD sheep were correctly assigned to their source genetic group, 63.9% of Yankasa, 61.2% of Balami and 45.2% of Uda were classified correctly by nearest neighbour discriminant analysis. The overall high Polymorphism Information Content (PIC) of all microsatellite markers ranged from 0.751 to 0.927 supporting their use in genetic characterization. Expected heterozygosity was high for all loci (0.783 to 0.93). Mean heterozygote deficiency across all populations (0.171 to 0.534) possibly indicate significant inbreeding (P < 0.05). Mean values for FST , FIT and FIS statistics across all loci were 0.088, 0.394 and 0.336 respectively. Yankasa and Balami are the most closely related breeds (DA = 0.184) while WAD and Balami are the farthest apart breeds (DA = 0.665), which is coincident with distance based on morphological analysis and population structure assessed by STRUCTURE. Conclusions: These results suggest that within-breed genetic variation in Nigerian sheep is higher than between-breeds and may be a valuable tool for genetic improvement and conservation. The higher genetic variability in Yankasa suggests the presence of unique ancestral alleles reflecting the presence of certain functional genes which may result in better adaptability in more agro-ecological zones of Nigeria. These genetic characteristics are potentially useful in planning improvement and conservation strategies in Nigerian indigenous sheep. | Brilliant O Agaviezor Sunday O Peters Mufliat A Adefenwa Abdulmojeed Yakubu Olufunmilayo A Adebambo Michael O Ozoje Christian ON Ikeobi Matthew Wheto Oyeyemi O Ajayi Samuel A Amusan Oludotun J Ekundayo Timothy M Sanni Moses Okpeku Gbolabo O Onasanya Marcos De Donato Babatunde M Ilori Kadir Kizilkaya Ikhide G Imumorin | 2013 | Journal of Animal Science and Biotechnology2013，4，1： | 0 |
| 3 | Could China’s journey of malaria elimination extend to Africa?显示文摘World Health Organization (WHO) certified China malaria-free on June 30, 2021, which brightens the goal of global malaria elimination efforts. China contributed its unique innovations to the global community: Artemisinin, discovered by Tu Youyou, has saved millions of lives globally;the “1-3-7” norm developed in 2012, has been adapted in the local contexts of countries in the Southeast Asia and Africa. How to the targets of Global Technical Strategy for Malaria (GTS) 2016−2030. By looking into the malaria control phase, towards elimination phase from 1960 to 2011 in sub-Saharan Africa and China, we found that the gap in malaria burden will widen unless the interventions in Africa are enhanced. It is imperative to identify the key China–Africa cooperation areas on malaria control and elimination, so that synergized efforts could be pooled together to help African countries achieve the elimination goal. The practices from China malaria control and elimination efforts could be leveraged to fast-track malaria elimination efforts in Africa, which makes it possible that the China’s journey of malaria elimination extends to Africa. | Duoquan Wang Shan Lv Wei Ding Shenning Lu Hongwei Zhang Kokouvi Kassegne Shang Xia Lei Duan Xuejiao Ma Lulu Huang Roly Gosling Joshua Levens Salim Abdulla Mutinta Mudenda Moses Okpeku Kenneth Kamwi Matengu Potiandi Serge Diagbouga Ning Xiao Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 0 |
| 4 | Y‑STR Kits and Y‑STR Diversity in the South African Population: A Review显示文摘The South African population consists of four ethnic groups,i.e.,Blacks,Coloreds,Indians,and Whites,and is considered the most diverse conglomeration of humans.In addition to autosomal short tandem repeat(STR)variation,an important tool to study population diversity is Y-chromosome(Y)-STR analysis.Y-STRs aid in forensic investigations and provide essential data about paternal lineage origins.Y-STR kits consisting of an array of stable and rapidly mutating markers offer crucial information on a given population’s genetic and haplotype diversity.This review discusses the development of Y-STR kits over the years and highlights some prominent Y-STR studies conducted on the South African population.The earliest Y-STR kit developed was the Y-PLEX™6,with the most recent being the UniQTyper™Y-10 Multiplex.The South African population studies show varying data,with the“minimal haplotype”having low discrimination capacity among the ethnic groups and the UniQTyper™Y-10 showing high genetic diversity among the ethnic groups of the country.There is a dearth of Y-STR studies on the South African population.With the advent of new Y-STR kits with increased discriminatory markers,additional studies are required to represent the South African population in the Y-STR databases.Considering the diversity of the South African population,establishment of a local/regional population database would be beneficial.In addition,data on the origins and prevalence of mutations and silent alleles should be obtained from STR datasets generated during kinship investigations(specifically,parentage tests)so that detailed information about the frequencies of mutations,silent alleles,and uniparental disomy in the South African population at Y STR loci can be estimated. | Sthabile Shabalala Meenu Ghai Moses Okpeku | 2022 | Journal of Forensic Science and Medicine2022，8，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员