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| 1 | Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms显示文摘It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness.However,the collective effects of SNPs have yet to be examined by experimental science.We here developed a novel approach to examine the relationship between traits and the total amount of SNPs in panels of genetic reference populations.We identified the minor alleles(MAs)in each panel and the MA content(MAC)that each inbred strain carried for a set of SNPs with genotypes determined in these panels.MAC was nearly linearly linked to quantitative variations in numerous traits in model organisms,including life span,tumor susceptibility,learning and memory,sensitivity to alcohol and anti-psychotic drugs,and two correlated traits poor reproductive fitness and strong immunity.These results suggest that the collective effects of SNPs are functional and do affect reproductive fitness. | YUAN DeJian ZHU ZuoBin TAN XiaoHua LIANG Jie ZENG Chen ZHANG JieGen CHEN Jun MA Long DOGAN Ayca BROCKMANN Gudrun GOLDMANN Oliver MEDINA Eva RICE Amanda D. MOYER Richard W. MAN Xian YI Ke LI YanKe LU Qing HUANG YiMin HUANG Shi | 2014 | Science China(Life Sciences)2014，57，9： | 2 |
| 2 | Effects of interleukin-8 on granulation tissue matration显示文摘 | Moyer KE Saggers GC Allison GM | 2002 | J Cell Physiol2002，193，10： | 1 |
| 3 | Capsular contracture after breast reconstruction:collagen fiber orientation and organization显示文摘 | Moyer KE Ehrlich HP | 2013 | Plast Reconstr Surg^2013，131，4： | 1 |
| 4 | Wound healing:the role of gap junctional communication in rat granulation tissue maturation显示文摘 | Moyer KE Davis A Saggers GC | 2002 | Exp Mol Pathol2002，72，： | 1 |
| 5 | The concept of pattern in craniofacial growth显示文摘 | Moyers RE Bookstein FL Guire KE | 1979 | Am J Orthod1979，76，： | 1 |
| 6 | Wound healing:The role of gap junctional communication in rat granulation tissue maturation显示文摘 | Moyer KE Davis A Saggers GC | 2002 | Exp Mol Pathol2002，72，： | 1 |
| 7 | Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication 显示文摘 | Moyer KE Saggers GC Ehrlich HP | 2004 | Wound Repair Regen2004，12，3： | 1 |
| 8 | Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering显示文摘 | Mischen BT Follmar KE Moyer KE | | 0，，3： | 1 |
| 9 | Differential diagnosis of Class Ⅱ malocclusion显示文摘 | Moyers RE Riolo ML Guire KE | 1980 | Am J Orthod1980，78，5： | 1 |
| 10 | Rat mast cel s enhance fibroblast proliferation and fibroblast-populated col agen lattice contraction through gap junctional intercel ular communications显示文摘 | Foley TT Saggers GC Moyer KE | | 0，，04： | 1 |
| 11 | Complex abdominal wall re- construction:an outcomes review显示文摘 | Henry CR Bradbum E Moyer KE | 2013 | Ann Plast Surg2013，71，3： | 1 |
| 12 | Capsular contracture after breast reconstruction:collagen fiber orientation and organization显示文摘 | Moyer KE Ehrlich HP | | 0，，4： | 1 |
| 13 | Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication显示文摘 | Moyer KE Saggers GC Ehrlich HP | 2004 | Wound Repair Regen2004，12，3： | 1 |
| 14 | Wound healing:the role of gap junctional communication in rat granulation tissue matuation显示文摘 | Moyer KE Davis A Saggers GC | 2002 | Exp Mol Pathol2002，72，1： | 1 |
| 15 | Modulation of human fibroblast gap junction intercellular communication by hyaluronan显示文摘 | Moyer KE Ehrlich HP | 2003 | J Cell Physiol2003，196，1： | 1 |
| 16 | Mast cells promote fibroblast populated collagen lattice contraction through gap junction intercellular communication显示文摘 | Moyer KE Saggers GL Ehrtich HP | 2004 | Wound Repair Regen2004，12，3： | 1 |
| 17 | Modulation of human fibroblast gap junction in tercellular communication by hyaluronan显示文摘 | Moyer KE Ehrlich HP | 2003 | Cell Physiol2003，196，1： | 1 |
| 18 | Differential diagnosis of class Ⅱ malocclusions显示文摘 | Moyers RE Riolo ML Guire KE | 1980 | Am J Orthod1980，78，： | 1 |
| 19 | Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering显示文摘 | Mischen BT Follmar KE Moyer KE | 2008 | Plast Reconstr Surg2008，122，3： | 1 |
| 20 | Anthocyanins, Phenolics, and Antioxidant Capacity in Diverse Small Fruits: Vaccinium, Rubus, and Rihes显示文摘 | Moyer RA Hummer KE Finn CE | 2002 | J Agric Food Chem2002，50，3： | 1 |
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