| 1 | Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila显示文摘Neuroligins (Nlgs ) 是在触处开发和功能起必要作用的 transmembrane 房间粘附分子。在 neuroligin 基因的基因变化与象孤独性那样的一些 neurodevelopmental 混乱被连接了。这些变异的 Nlgs 主要在 endoplasmic 蜂窝胃被保留(嗯) 。然而,位于正常 Nlg 成熟和 trafficking 下面的机制仍然保持大部分未知。这里,我们发现那果蝇 neuroligin (DNlg2 ) 2 在整个发展阶段在许多果蝇纸巾在 ER 经历解朊的劈开。包含 Y642T698 的一个区域为这个过程被要求。不成熟的非劈得开的 DNlg2 在 ER 被保留并且非功能。DNlg2 的 C 终端碎片而不是全身或非劈得开的 DNlg2 能救 dnlg2 删除导致的神经与肌的连接缺点和 GluRIIB 减小。有趣地,在 DNlg2 的联系孤独性的 R598C 变化在 DNlg2 解朊的过程导致类似的显著缺点,揭示在孤独性致病的不适当的 Nlg 劈开的一个潜在的角色并且嗯出口。一起,我们的调查结果揭开在 ER 经由解朊的劈开控制 DNlg2 成熟和 trafficking 的特定的机制,建议 Nlgs 的使不安的解朊的劈开多半贡献孤独性混乱。 | Renjun Tu Jinjun Qian Menglong Rui Nana Tao Mingkuan Sun Yan Zhuang Huihui Lv Junhai Han Moyi Li Wei Xie | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
| 2 | Expert consensus on the clinical application of recombinant adenovirus human p53 for head and neck cancers显示文摘The first gene therapy product,recombinant adenovirus human p53(rAd-p53),has been approved by CFDA since 2013.During these years,most of the clinical trials and the relevant basic research were carried out by Chinese oncologists.Gendicine was proved to be a safe and promising gene therapy drug for patients who suffered from head and neck squamous cell carcinoma(HNSCC).The basic therapeutic theories of gene therapy were totally different from the traditional ones,such as surgeries or radioand chemotherapy,and the evaluation of treatment outcomes should also be changed simultaneously.However,there still existed a lot of misunderstandings about gene therapy,which resulted in improper administration,insufficient dosage calculation,and treatment cycles,and the treatment outcomes were unsatisfactory,especially for inexperienced oncologists or hospitals.Therefore,we will provide some practical guidance here on the gene therapy of rAd-p53 based on our previous research and experience,which focused on the basic theories and clinical issues,to answer the questions arising during the clinical of gene therapy and to accelerate the development of gene therapy for the benefit of patients bearing malignant tumors. | Yi Li Wei Guo Xiuqin Li Jianguo Zhang Moyi Sun Zhangui Tang Wei Ran Kai Yang Guilin Huang Longjiang Li | 2021 | International Journal of Oral Science2021，13，4： | 0 |
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