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您的检索式：作者名="Muhammad Sahid"
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| 1 | Effects of 8-Hydroxyisocapnolactone-2-3-diol and friedelin on mast cell degranulation显示文摘Objective: To investigate the effects of friedelin(terpenoid) and 8-hydroxyisocapnolactone-2-3-diol(coumarin) with concentration 10 mM, 30 m M, and 100 mM on inhibiting mast cells(MCs) degranulation.Methods: The investigation was performed in vitro by administering each compound into rat peritoneal MCs and rat basophilic leukemia-2 H3 cells followed by activation with50 mg/m L of compound 48/80 or 1 m M of ionomycin. The concentration of histamine released from each group was measured by a high-performance liquid chromatographyfluorometry system with post-column derivatization using o-phthalaldehyde.Results: 8-Hydroxyisocapnolactone-2-3-diol inhibited degranulation of compound 48/80 activated-rat peritoneal MCs with the histamine release percentages of 74.57%,72.21% and 51.79% when the 10 mM, 30 m M and 100 mM concentrations were used,respectively. Where as about 81% histamine was released by the control group.Degranulation inhibition ability was also observed in ionomycin-activated rat basophilic leukemia-2 H3 cells. In contrast, friedelin failed to inhibit degranulation in either cell type.The inhibition of 8-hydroxyisocapnolactone-2-3-diol was not related to the depletion of histamine synthesis as implied by the total histamine measurement.Conclusions: These results exhibit the promising of 8-hydroxyisocapnolactone-2-3-diol is a potential parent structure for developing a MCs stabilizer. | Muhammad Novrizal Abdi Sahid Agung Endro Nugroho Ratna Asmah Susidarti Kazutaka Maeyama | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 0 |
| 2 | Measurement of ^(59)Co(ai,x)reaction cross sections with the fast neutrons based on the ^(9)Be(p,n)reaction显示文摘The cross sections of the ^(59)Co(n,x)reaction in the average energy range of 15.2-37.2 MeV were meas-ured using activation and an off-line γ-ray spectrometric technique.The neutrons were generated from the ^(9)Be(p,n)reaction with proton beam energies of 25-45 MeV at the MC-50 Cyclotron facility of the Korean Institute of Radi-ological and Medical Sciences(KIRAMS).Theoretical cal lculations of neutron-induced reactions on ^(59)Co were per-formed using the nuclear model code TALYS-1.9.The results for the ^(59)Co(n,x)reactions were compared with the theoretical values obtained using TALYS-1.9 and the literature data provided in EXFOR and the TENDL 2019 nuc-lear data library.The theoretical values obtained using TALYS-1.9 with adjusted parameters are comparable to the experimental data.The measured reaction cross sections of a few radionuclides are new,and the others are compar-able to the literature data,and thus,they can strengthen the database.The present study on cross sections leads to useful insight into the mechanisms of ^(59)Co(n,x)reactions. | Muhammad Zaman Muhammad Nadeem Muhammad Sahid Kwangsoo Kim Guinyun Kim Nguyen Thi Hien | 2021 | Chinese Physics C2021，45，4： | 0 |
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